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phosphodiesterase 2A, CGMP-Stimulated Proteins (PDE2A)

activation induces decreased cAMP accumulation\; involved in nitric oxide mediated signaling in cardiac fibroblasts [RGD, Feb 2006].. Additionally we are shipping phosphodiesterase 2A, CGMP-Stimulated Antibodies (70) and phosphodiesterase 2A, CGMP-Stimulated Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PDE2A 5138 O00408
PDE2A 207728  
PDE2A 81743 Q01062
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Top phosphodiesterase 2A, CGMP-Stimulated Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$365.64
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$344.14
Details

PDE2A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced phosphodiesterase 2A, CGMP-Stimulated Proteins

  1. Human PDE2A Protein expressed in Baculovirus infected Insect Cells - ABIN2005384 : Iffland, Kohls, Low, Luan, Zhang, Kothe, Cao, Kamath, Ding, Ellenberger: Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system. in Biochemistry 2005 (PubMed)
    Show all 3 references for ABIN2005384

More Proteins for phosphodiesterase 2A, CGMP-Stimulated (PDE2A) Interaction Partners

Human phosphodiesterase 2A, CGMP-Stimulated (PDE2A) interaction partners

  1. Lu AF33241 represents a novel PDE2A/PDE10A (show PDE10A Proteins) inhibitor tool which can penetrate the blood brain barrier.

  2. curcumin exerts its in vitro anti-angiogenic and in vivo anti-tumour properties through combined PDE2 and PDE4 (show PDE4A Proteins) inhibition

  3. PDE2A is involved in growth and invasion of human malignant melanoma PMP cells.

  4. This study reports the X-ray crystal structure of PDE2A in complex with a highly selective, nanomolar inhibitor (BAY60-7550) at 1.9 A resolution, and the structure of apo (show C9orf3 Proteins) PDE2 at 2.0 A resolution.

  5. PDE2 overexpression in healthy cardiomyocytes reduces the rise in cyclic AMP (show APRT Proteins) levels and L-type calcium current amplitude, and abolishes the inotropic effect following acute beta-adrenergic receptor stimulation.

  6. Our results demonstrated that the PDE2A2 variant carrying point mutations is expressed in PMP cells and may affect cell cycle progression by modulating cyclin A (show CCNA2 Proteins) expression.

  7. the phosphodiesterase 2A isoform localized to mitochondria regulates respiration

  8. Inhibition of PDE2 resulted in higher levels of intracellular cAMP than inhibition of PDE3A (show PDE3A Proteins) suggesting this PDE (show ALDH7A1 Proteins) may be the more important regulator of cAMP in human platelets.

  9. TNF-alpha (show TNF Proteins)-mediated up-regulation of PDE2 may destabilize endothelial barrier function in sepsis

  10. Phosphodiesterase 2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin (show F2 Proteins) via Rac1 and NADPH oxidase 2 (show CYBB Proteins).

Mouse (Murine) phosphodiesterase 2A, CGMP-Stimulated (PDE2A) interaction partners

  1. Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by PDE2A.

  2. Effect of PDE2 inhibition on stress-induced memory impairment is potentially mediated via modulation of neuroplasticity-related NMDAR (show GRIN1 Proteins)-CaMKII (show CAMK2G Proteins)-cGMP/cAMP signaling.

  3. We conclude that increased AM PDE2A is an important negative regulator of macrophage iNOS (show NOS2 Proteins) expression.

  4. results demonstrate strong presynaptic inhibition by natriuretic peptides in the brain and suggest important physiological and behavioral roles of PDE2A in modulating neurotransmitter release

  5. cGMP binding to PDE2 GAF-B activates the enzyme rapidly, stoichiometrically, and in an all or none fashion, rather than variably over a large range of cyclic nucleotide concentrations

  6. HV(T)-induced endothelial barrier dysfunction resulted from a simultaneous increase in NO/sGC (show NPR1 Proteins)-derived cGMP and PDE2A expression causing decreased cAMP.

  7. Phosphodiesterase 2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin (show F2 Proteins) via Rac1 and NADPH oxidase 2 (show CYBB Proteins).

phosphodiesterase 2A, CGMP-Stimulated (PDE2A) Protein Profile

Protein Summary

activation induces decreased cAMP accumulation\; involved in nitric oxide mediated signaling in cardiac fibroblasts

Gene names and symbols associated with PDE2A

  • phosphodiesterase 2A, cGMP-stimulated (PDE2A)
  • phosphodiesterase 2A, cGMP-stimulated (pde2a)
  • phosphodiesterase 2A, cGMP-stimulated (Pde2a)
  • CGS-PDE protein
  • cGSPDE protein
  • Pde2 protein
  • PDE2A protein
  • PDE2A1 protein
  • Pde2a2 protein
  • PED2A4 protein

Protein level used designations for PDE2A

phosphodiesterase 2A, cGMP-stimulated , cGMP-dependent 3',5'-cyclic phosphodiesterase , phosphodiesterase 2A , cGMP-dependent 3',5'-cyclic phosphodiesterase-like , cGMP-stimulated phosphodiesterase 1 , cGMP-stimulated phosphodiesterase 4 , cyclic GMP-stimulated phosphodiesterase , CGS-PDE , cGSPDE , cyclic GMP stimulated phosphodiesterase , c-GMP stimulated phosphodiesterase

GENE ID SPECIES
451405 Pan troglodytes
609574 Canis lupus familiaris
718479 Macaca mulatta
780063 Xenopus (Silurana) tropicalis
100014975 Monodelphis domestica
100052619 Equus caballus
100480274 Ailuropoda melanoleuca
100587547 Nomascus leucogenys
5138 Homo sapiens
207728 Mus musculus
81743 Rattus norvegicus
281971 Bos taurus
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