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phosphodiesterase 3A, CGMP-Inhibited Proteins (PDE3A)

PDE3A encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. Additionally we are shipping PDE3A Antibodies (50) and PDE3A Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PDE3A 54611 Q9Z0X4
PDE3A 50678 Q62865
PDE3A 5139 Q14432
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Top PDE3A Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag,GST tag 100 μg Log in to see 16 Days
$437.80
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$365.64
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$344.14
Details
HOST_Escherichia coli (E. coli) Chicken Un-conjugated   5 applications Log in to see 1 to 2 Days
$344.14
Details

PDE3A Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Rat (Rattus)
Human , , ,
, ,

Top referenced PDE3A Proteins

  1. Human PDE3A Protein expressed in Baculovirus infected Insect Cells - ABIN2004880 : Penmatsa, Zhang, Yarlagadda, Li, Conoley, Yue, Bahouth, Buddington, Zhang, Nelson, Sonecha, Manganiello, Wine, Naren: Compartmentalized cyclic adenosine 3',5'-monophosphate at the plasma membrane clusters PDE3A and cystic fibrosis transmembrane conductance regulator into microdomains. in Molecular biology of the cell 2010 (PubMed)

More Proteins for phosphodiesterase 3A, CGMP-Inhibited (PDE3A) Interaction Partners

Mouse (Murine) phosphodiesterase 3A, CGMP-Inhibited (PDE3A) interaction partners

  1. PDE3A is the primary isozyme modulating basal myocardial contractility and sarcoplasmic reticulum divalent calcium ion (Ca2 (show CA2 Proteins)+) content.

  2. Discussion of role of PDE3A, not PDE3B, in cell cycle progression in vascular smooth muscle and oocytes via regulation of cAMP levels. Is inhibition of PDE3A a possible target for treatment of cardiovascular diseases or female infertility? [REVIEW]

  3. PDE3A regulates VSMC growth via two complementary pathways

  4. phosphodiesterase-III inhibitor prevents the hemorrhagic transformation induced by focal cerebral ischemia in mice treated with tPA (show PLAT Proteins)

  5. Results provide evidence indicating that resumption of meiosis in vivo and in vitro requires cyclic nucleotide phosphodiesterase 3A activity.

  6. These data indicate that activation of PDE3A by PKB/Akt (show AKT1 Proteins)-mediated phosphorylation plays a role in the control of PDE3A activity in mammalian oocytes.

  7. Role of Pde3a in regulating platelet and cardiac function using subtype-selective knockout mice is reported.

  8. Gpr3 (show GPR3 Proteins) is epistatic to Pde3a and fertility as well as meiotic arrest in the PDE3A-deficient oocyte is dependent on the activity of GPR3 (show GPR3 Proteins).

Human phosphodiesterase 3A, CGMP-Inhibited (PDE3A) interaction partners

  1. Chemical proteomics results show that besides known interactors such as 14-3-3 (show YWHAQ Proteins) family proteins, PDE3A was found to associate with a PP2A (show PPP2R4 Proteins) complex composed of a regulatory, scaffold and catalytic subunit.

  2. We found a highly significant association between PDE3A-SLCO1C1 (show SLCO1C1 Proteins) and the clinical response to TNF (show TNF Proteins) blockers

  3. A heterozygous missense mutation in PDE3A causes autosomal dominant hypertension with brachydactyly.

  4. PDE3A is part of a SERCA2 (show ATP2A2 Proteins) signaling complex in cardiac myocytes.

  5. the genotypic and allelic frequencies of the rs7134375 SNP are different between the Mulao and Han populations. the PDE3A rs7134375 SNP is associated with serum TG levels in the Mulao population, however, not in the Han population.

  6. The PDE3A-SLCO1C1 (show SLCO1C1 Proteins) locus rs3794271 SNP showed a highly significant association with anti-TNF (show TNF Proteins) treatment response.

  7. PI3Kgamma (show PIK3CG Proteins) coordinates the coincident signaling of the major cardiac PDE3 and PDE4 (show PDE4A Proteins) isoforms, thus orchestrating a feedback loop that prevents calcium-dependent ventricular arrhythmia.

  8. Anagrelide suppresses megakaryocytopoiesis by reducing the expression levels of GATA-1 (show GATA1 Proteins) and FOG-1 (show ZFPM1 Proteins) via a PDEIII-independent mechanism that is differentiation context-specific and does not involve inhibition of MPL (show MPL Proteins)-mediated early signal transduction events

  9. Data show that PDE3A inhibition augments CFTR-dependent submucosal gland secretion and actin skeleton disruption decreases secretion.

  10. There was a concentration-dependent inhibition in the increase of intracellular Ca2 (show CA2 Proteins)+ with PDE3 inhibition and significantly less with PDE2 (show PDE2A Proteins) inhibition.

Pig (Porcine) phosphodiesterase 3A, CGMP-Inhibited (PDE3A) interaction partners

  1. Data show that PDE3A inhibition augments CFTR-dependent submucosal gland secretion and actin skeleton disruption decreases secretion.

  2. Results demonstrated that PDE3A is the major cAMP-degrading PDE (show TWIST1 Proteins) in the oocyte.

  3. Degradation of the intracellular cyclic nucleotide by Pde3a is transcriptionally up-regulated via a cAMP-dependent pathway in cumulus cells, suggesting that it has a functional role during the ovulatory gonadotropin surge.

PDE3A Protein Profile

Protein Summary

This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with PDE3A

  • phosphodiesterase 3A, cGMP-inhibited (PDE3A)
  • phosphodiesterase 3a (Pde3a)
  • phosphodiesterase 3A, cGMP-inhibited (pde3a)
  • phosphodiesterase 3A, cGMP inhibited (Pde3a)
  • A930022O17Rik protein
  • C87899 protein
  • CGI-PDE protein
  • CGI-PDE-A protein
  • CGI-PDE A protein
  • Pde3a protein
  • RNPDE3A protein
  • si:dkey-48h7.2 protein

Protein level used designations for PDE3A

phosphodiesterase 3A, cGMP-inhibited , cGMP-inhibited 3',5'-cyclic phosphodiesterase A , phosphodiesterase 3a , cGMP-inhibited 3',5'-cyclic phosphodiesterase A-like , CGI-PDE A , cGMP-inhibited phosphodiesterase , cyclic GMP-inhibited phosphodiesterase A , cyclic nucleotide phosphodiesterase , cAMP phosphodiesterase, myocardial cGMP-inhibited

GENE ID SPECIES
465329 Pan troglodytes
536636 Bos taurus
704524 Macaca mulatta
100009330 Oryctolagus cuniculus
100011746 Monodelphis domestica
100034086 Equus caballus
100302667 Cavia porcellus
100405271 Callithrix jacchus
100540515 Meleagris gallopavo
100555208 Anolis carolinensis
100583391 Nomascus leucogenys
567051 Danio rerio
54611 Mus musculus
50678 Rattus norvegicus
5139 Homo sapiens
418185 Gallus gallus
396555 Sus scrofa
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