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anti-phosphodiesterase 4B, CAMP-Specific (PDE4B) Antibodies

PDE4B is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Additionally we are shipping phosphodiesterase 4B, CAMP-Specific Proteins (7) and phosphodiesterase 4B, CAMP-Specific Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PDE4B 18578  
PDE4B 24626 P14646
PDE4B 5142 Q07343
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Top anti-phosphodiesterase 4B, CAMP-Specific Antibodies at antibodies-online.com

Showing 10 out of 95 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-PDE4B Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Human heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, FACS, WB Flow cytometric analysis of Ramos cells using using PDE4B Antibody (Center) Cat.-No AP53236PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Western blot analysis of PDE4B Antibody (Center) in Ramos cell line lysates (35ug/lane). This demonstrates the PDE4B antibody detected the PDE4B protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Chicken Rabbit Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Chicken Rabbit Un-conjugated IF, IP, WB   0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Chicken Rabbit Un-conjugated IF, IP, WB   0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Chicken Rabbit Un-conjugated WB   0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-Pde4b AntibodyTitration: 1.0 µg/mL  Positive Control: Mouse Heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, WB PDE4B Antibody (Center) (ABIN655630) flow cytometric analysis of Ramos cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$324.50
Details

PDE4B Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)
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Rat (Rattus)
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Human , , , ,
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Top referenced anti-phosphodiesterase 4B, CAMP-Specific Antibodies

  1. Chicken Polyclonal PDE4B Primary Antibody for WB - ABIN493269 : McLaughlin, Cieslinski, Burman, Torphy, Livi: A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA. in The Journal of biological chemistry 1993 (PubMed)
    Show all 3 references for ABIN493269

  2. Chicken Polyclonal PDE4B Primary Antibody for IF, IP - ABIN493267 : Huston, Lumb, Russell, Catterall, Ross, Steele, Bolger, Perry, Owens, Houslay: Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3. in The Biochemical journal 1998 (PubMed)
    Show all 2 references for ABIN493267

  3. Human Polyclonal PDE4B Primary Antibody for EIA, FACS - ABIN954065 : Souza, Remington, Meltzer, Lieberman, Kennedy, Wong: Phosphodiesterase 4B genetic variants are not associated with antipsychotic-induced tardive dyskinesia. in International clinical psychopharmacology 2010 (PubMed)
    Show all 2 references for ABIN954065

  4. Chicken Polyclonal PDE4B Primary Antibody for WB - ABIN2786603 : Fatemi, King, Reutiman, Folsom, Laurence, Lee, Fan, Paciga, Conti, Menniti: PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia. in Schizophrenia research 2008 (PubMed)
    Show all 2 references for ABIN2786603

  5. Human Polyclonal PDE4B Primary Antibody for WB - ABIN374649 : Millar, Pickard, Mackie, James, Christie, Buchanan, Malloy, Chubb, Huston, Baillie, Thomson, Hill, Brandon, Rain, Camargo, Whiting, Houslay, Blackwood, Muir, Porteous: DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. in Science (New York, N.Y.) 2005 (PubMed)

More Antibodies against phosphodiesterase 4B, CAMP-Specific Interaction Partners

Mouse (Murine) phosphodiesterase 4B, CAMP-Specific (PDE4B) interaction partners

  1. PDE4B phosphorylated by AMPK (show PRKAA1 Antibodies) at Ser304 is important for activation.

  2. Lymphomas developing in a Pde4b-null background display significantly lower microvessel density in association with lower VEGF (show VEGFA Antibodies) levels and PI3K/AKT (show AKT1 Antibodies) activity.

  3. Genetic variations in DISC1 (show DISC1 Antibodies) influence formation of biochemical complex with PDE4 (show PDE4A Antibodies) and GSK-3 (show GSK3b Antibodies) and strengthen the possibility of synergistic interactions between these proteins.

  4. PDE4B-deficient mice display impaired reversal learning in the Morris water maze compared to wild-type littermates.

  5. Results identify PDE4B in the CaV1.2 (show CACNA1C Antibodies) complex as a critical regulator of ICa during beta-AR stimulation and suggest that distinct PDE4 (show PDE4A Antibodies) subtypes are important for normal regulation of calcium-induced calcium release in cardiomyocytes.

  6. Findings demonstrate that PDE4D (show PDE4D Antibodies) and PDE4B have specialized functions in mouse embryonic fibroblasts with PDE4B controlling cAMP in a discrete subdomain near the plasma membrane.

  7. induction is esssential for LPS (show TLR4 Antibodies)-activated tnf-alpha (show TNF Antibodies) responses

  8. PDE4B mediates the antipsychotic effects of rolipram in conditioned avoidance responding; the PDE4B-regulated cyclic adenosine monophosphate signaling pathway may play a role in the pathophysiology and pharmacotherapy of psychosis

  9. the PDE4B subfamily is involved in signaling pathways that contribute to anxiogenic-like effects on behavior.

  10. Altered DISC1 (show DISC1 Antibodies)-PDE4B interaction may thus underlie the symptoms of some cases of schizophrenia and depression.(Review)

Human phosphodiesterase 4B, CAMP-Specific (PDE4B) interaction partners

  1. This meta-analysis suggests that PDE4B SNPs are genetically associated with susceptibility to schizophrenia.

  2. Our results suggest that PDE4B does not play an important role during the chemotactic response of human neutrophils

  3. Our results support previously reported association of PDE4B variations with schizophrenia in other populations.

  4. analysis of the mechanism underlying synergistic up-regulation of PDE4B2 via a cross-talk between PKA-Cbeta and p65 (show GORASP1 Antibodies)

  5. ototopical post-inoculation administration of a PDE4 (show PDE4A Antibodies) inhibitor suppresses inflammation in this animal model, thus demonstrating the therapeutic potential of targeting PDE4 (show PDE4A Antibodies)

  6. PDE4B was found to be highly expressed in CD4 (show CD4 Antibodies)+ lymphoid cancer cells, which suggests that it may represent a physiological role unique to the CD8 (show CD8A Antibodies)+ and lymphoid cancer cells and thus might represent a target for treatment of certain lymphoid diseases

  7. Short Disrupted-in-Schizophrenia (DISC)1 (show DISC1 Antibodies) splice variants show reduced or no binding to nudE nuclear distribution E homolog (NDEL)1 (show NDEL1 Antibodies) and PDE4B proteins but fully interact with fasciculation/elongation zeta (FEZ)1 (show LZTS1 Antibodies) and glycogen synthase kinase 3 GSK3beta (show GSK3b Antibodies).

  8. PDE4B mediates ERK (show EPHB2 Antibodies)-dependent up-regulation of mucin (show SLC13A2 Antibodies) MUC5AC by S. pneumoniae by inhibiting cAMP-PKA-dependent MKP-1 (show DUSP1 Antibodies) pathway.

  9. a study of Northwestern Han Chinese found that rs472952 is significantly associated with schizophrenia (SCZ) and rs7537440 is associated with SCZ in females; results provide further evidence that PDE4B may play important roles in the etiology of SCZ

  10. PDE4B was downregulated and the protein kinase A pathway was activated in castration-resistant LNCaP prostate cancer cells. PDE4B expression was reduced in advanced prostate cancer and PDE4B knockdown promoted castration-resistant growth of LNCaP cells.

Pig (Porcine) phosphodiesterase 4B, CAMP-Specific (PDE4B) interaction partners

  1. QTL-CI for IMF (show MDFI Antibodies) was reconfirmed with high significance, and its position was narrowed down to an interval of 4 cM (the region defined by markers PDE4B and SW1881)

phosphodiesterase 4B, CAMP-Specific (PDE4B) Antigen Profile

Protein Summary

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with PDE4B

  • phosphodiesterase 4B, cAMP-specific (pde4b) antibody
  • phosphodiesterase 4B, cAMP-specific (PDE4B) antibody
  • phosphodiesterase 4B, cAMP specific (Pde4b) antibody
  • DPDE4 antibody
  • dunce antibody
  • PDE4/IVb antibody
  • Pde4B1 antibody
  • Pde4B2 antibody
  • Pde4B3 antibody
  • Pde4B4 antibody
  • PDE4B5 antibody
  • PDEIVB antibody
  • R74983 antibody

Protein level used designations for PDE4B

phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog) , phosphodiesterase 4B, cAMP-specific , phosphodiesterase 4B , 3',5'-cyclic AMP phosphodiesterase , DPDE4 , Phosphodiesterase 4B cAMP-specific (dunce , Phosphodiesterase 4B, cAMP-specific (dunce , cAMP-specific 3',5'-cyclic phosphodiesterase 4B , PDE32 , cAMP-specific phosphodiesterase-4 B isoform , dunce-like phosphodiesterase E4 , phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) , phosphodiesterase 4B, cAMP specific

GENE ID SPECIES
780324 Xenopus (Silurana) tropicalis
100604983 Nomascus leucogenys
18578 Mus musculus
24626 Rattus norvegicus
5142 Homo sapiens
424700 Gallus gallus
444562 Xenopus laevis
100037941 Sus scrofa
100124505 Bos taurus
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