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phosphodiesterase 4B, CAMP-Specific Proteins (PDE4B)

PDE4B is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Additionally we are shipping phosphodiesterase 4B, CAMP-Specific Antibodies (90) and phosphodiesterase 4B, CAMP-Specific Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PDE4B 18578  
PDE4B 24626 P14646
PDE4B 5142 Q07343
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Top phosphodiesterase 4B, CAMP-Specific Proteins at

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag,GST tag 50 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

PDE4B Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)
Rat (Rattus)
Human , , ,
, ,

Top referenced phosphodiesterase 4B, CAMP-Specific Proteins

  1. Human PDE4B Protein expressed in Baculovirus infected Insect Cells - ABIN2004327 : Card, England, Suzuki, Fong, Powell, Lee, Luu, Tabrizizad, Gillette, Ibrahim, Artis, Bollag, Milburn, Kim, Schlessinger, Zhang: Structural basis for the activity of drugs that inhibit phosphodiesterases. in Structure (London, England : 1993) 2004 (PubMed)
    Show all 5 references for ABIN2004327

More Proteins for phosphodiesterase 4B, CAMP-Specific (PDE4B) Interaction Partners

Mouse (Murine) phosphodiesterase 4B, CAMP-Specific (PDE4B) interaction partners

  1. PDE4B phosphorylated by AMPK (show PRKAA1 Proteins) at Ser304 is important for activation.

  2. Lymphomas developing in a Pde4b-null background display significantly lower microvessel density in association with lower VEGF (show VEGFA Proteins) levels and PI3K/AKT (show AKT1 Proteins) activity.

  3. Genetic variations in DISC1 influence formation of biochemical complex with PDE4 and GSK-3 and strengthen the possibility of synergistic interactions between these proteins.

  4. PDE4B-deficient mice display impaired reversal learning in the Morris water maze compared to wild-type littermates.

  5. Results identify PDE4B in the CaV1.2 (show CACNA1C Proteins) complex as a critical regulator of ICa during beta-AR stimulation and suggest that distinct PDE4 (show PDE4A Proteins) subtypes are important for normal regulation of calcium-induced calcium release in cardiomyocytes.

  6. Findings demonstrate that PDE4D (show PDE4D Proteins) and PDE4B have specialized functions in mouse embryonic fibroblasts with PDE4B controlling cAMP in a discrete subdomain near the plasma membrane.

  7. induction is esssential for LPS (show TLR4 Proteins)-activated tnf-alpha (show TNF Proteins) responses

  8. PDE4B mediates the antipsychotic effects of rolipram in conditioned avoidance responding; the PDE4B-regulated cyclic adenosine monophosphate signaling pathway may play a role in the pathophysiology and pharmacotherapy of psychosis

  9. the PDE4B subfamily is involved in signaling pathways that contribute to anxiogenic-like effects on behavior.

  10. Altered DISC1 (show DISC1 Proteins)-PDE4B interaction may thus underlie the symptoms of some cases of schizophrenia and depression.(Review)

Human phosphodiesterase 4B, CAMP-Specific (PDE4B) interaction partners

  1. This meta-analysis suggests that PDE4B SNPs are genetically associated with susceptibility to schizophrenia.

  2. Our results suggest that PDE4B does not play an important role during the chemotactic response of human neutrophils

  3. Our results support previously reported association of PDE4B variations with schizophrenia in other populations.

  4. analysis of the mechanism underlying synergistic up-regulation of PDE4B2 via a cross-talk between PKA-Cbeta and p65 (show GORASP1 Proteins)

  5. ototopical post-inoculation administration of a PDE4 (show PDE4A Proteins) inhibitor suppresses inflammation in this animal model, thus demonstrating the therapeutic potential of targeting PDE4 (show PDE4A Proteins)

  6. PDE4B was found to be highly expressed in CD4 (show CD4 Proteins)+ lymphoid cancer cells, which suggests that it may represent a physiological role unique to the CD8 (show CD8A Proteins)+ and lymphoid cancer cells and thus might represent a target for treatment of certain lymphoid diseases

  7. Short Disrupted-in-Schizophrenia (DISC)1 splice variants show reduced or no binding to nudE nuclear distribution E homolog (NDEL)1 and PDE4B proteins but fully interact with fasciculation/elongation zeta (FEZ)1 and glycogen synthase kinase 3 GSK3beta.

  8. PDE4B mediates ERK (show EPHB2 Proteins)-dependent up-regulation of mucin (show SLC13A2 Proteins) MUC5AC by S. pneumoniae by inhibiting cAMP-PKA-dependent MKP-1 (show DUSP1 Proteins) pathway.

  9. a study of Northwestern Han Chinese found that rs472952 is significantly associated with schizophrenia (SCZ) and rs7537440 is associated with SCZ in females; results provide further evidence that PDE4B may play important roles in the etiology of SCZ

  10. PDE4B was downregulated and the protein kinase A pathway was activated in castration-resistant LNCaP prostate cancer cells. PDE4B expression was reduced in advanced prostate cancer and PDE4B knockdown promoted castration-resistant growth of LNCaP cells.

Pig (Porcine) phosphodiesterase 4B, CAMP-Specific (PDE4B) interaction partners

  1. QTL-CI for IMF (show MDFI Proteins) was reconfirmed with high significance, and its position was narrowed down to an interval of 4 cM (the region defined by markers PDE4B and SW1881)

phosphodiesterase 4B, CAMP-Specific (PDE4B) Protein Profile

Protein Summary

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with PDE4B

  • phosphodiesterase 4B, cAMP-specific (pde4b)
  • phosphodiesterase 4B, cAMP-specific (PDE4B)
  • phosphodiesterase 4B, cAMP specific (Pde4b)
  • DPDE4 protein
  • dunce protein
  • PDE4/IVb protein
  • Pde4B1 protein
  • Pde4B2 protein
  • Pde4B3 protein
  • Pde4B4 protein
  • PDE4B5 protein
  • PDEIVB protein
  • R74983 protein

Protein level used designations for PDE4B

phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog) , phosphodiesterase 4B, cAMP-specific , phosphodiesterase 4B , 3',5'-cyclic AMP phosphodiesterase , DPDE4 , Phosphodiesterase 4B cAMP-specific (dunce , Phosphodiesterase 4B, cAMP-specific (dunce , cAMP-specific 3',5'-cyclic phosphodiesterase 4B , PDE32 , cAMP-specific phosphodiesterase-4 B isoform , dunce-like phosphodiesterase E4 , phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) , phosphodiesterase 4B, cAMP specific

780324 Xenopus (Silurana) tropicalis
100604983 Nomascus leucogenys
18578 Mus musculus
24626 Rattus norvegicus
5142 Homo sapiens
424700 Gallus gallus
444562 Xenopus laevis
100037941 Sus scrofa
100124505 Bos taurus
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