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PDE4D encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. Additionally we are shipping PDE4D Kits (28) and PDE4D Proteins (7) and many more products for this protein.
Showing 10 out of 84 products:
Chicken Polyclonal PDE4D Primary Antibody for WB - ABIN493282
Houslay, Baillie: The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways. in Biochemical Society transactions 2003
Show all 4 references for ABIN493282
Mouse (Murine) Polyclonal PDE4D Primary Antibody for IP, WB - ABIN493284
Bolger, Erdogan, Jones, Loughney, Scotland, Hoffmann, Wilkinson, Farrell, Houslay: Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene. in The Biochemical journal 1998
Show all 4 references for ABIN493284
Mouse (Murine) Polyclonal PDE4D Primary Antibody for WB - ABIN493298
Alvarez, Sette, Yang, Eglen, Wilhelm, Shelton, Conti: Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3. in Molecular pharmacology 1995
Show all 4 references for ABIN493298
Human Polyclonal PDE4D Primary Antibody for IF, IP - ABIN493279
Yarwood, Steele, Scotland, Houslay, Bolger: The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform. in The Journal of biological chemistry 1999
Show all 4 references for ABIN493279
Human Polyclonal PDE4D Primary Antibody for ELISA, WB - ABIN185530
Houslay: The long and short of vascular smooth muscle phosphodiesterase-4 as a putative therapeutic target. in Molecular pharmacology 2005
Show all 3 references for ABIN185530
Mouse (Murine) Polyclonal PDE4D Primary Antibody for IHC, WB - ABIN3022337
Dlaboga, Hajjhussein, ODonnell: Regulation of phosphodiesterase-4 (PDE4) expression in mouse brain by repeated antidepressant treatment: comparison with rolipram. in Brain research 2006
Show all 2 references for ABIN3022337
Human Polyclonal PDE4D Primary Antibody for EIA, WB - ABIN374635
Bazhin, Kahnert, Kimpfler, Schadendorf, Umansky: Distinct metabolism of cyclic adenosine monophosphate in regulatory and helper CD4+ T cells. in Molecular immunology 2010
Human Polyclonal PDE4D Primary Antibody for WB - ABIN374854
Houslay, Baillie, Maurice: cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling. in Circulation research 2007
The authors demonstrate that the Attention Deficit Disorder with Hyperactivity phenotype depends on a dysregulation of CREB (show CREB1 Antibodies) signaling exerted by a kinase-independent PI3Kgamma (show PIK3CG Antibodies)-PDE4D interaction in the noradrenergic neurons of the locus coeruleus.
SIK1 (show SIK1 Antibodies) serves as a part of a self-regulatory circuit to modulate insulin (show INS Antibodies) secretion from pancreatic beta-cells by controlling cAMP concentration through modulation of PDE4D activity.
Cytokine-induced iNOS (show NOS2 Antibodies) and ERK1/2 (show MAPK1/3 Antibodies) inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle, contributing to colonic dysmotility during inflammation.
the loss of function of either DISC1 (show DISC1 Antibodies) or ATF4 (show ATF4 Antibodies) increases PDE4D9 transcription, and the association of DISC1 (show DISC1 Antibodies) with the PDE4D9 locus requires ATF4 (show ATF4 Antibodies)
these results suggest that Pde4d might serve specific biological functions in regulating the development process of the mouse embryo, and that CpG methylation of the Pde4d promoter may play an important role in regulating Pde4d at a transcriptional level.
Calcineurin (show PPP3CA Antibodies) regulates degradation of phosphodiesterase 3B (show PDE3B Antibodies), in addition to phosphodiesterase 4D.
Beta-arrestin-2 (show ARRB2 Antibodies) scaffolding of phosphodiesterase PDE4D5 to the plasma membrane was required for TRPV1 (show TRPV1 Antibodies) desensitization.
Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2 (show CA2 Antibodies)+ release and cardiac contractility, independently of L-type Ca2 (show CA2 Antibodies)+ current.
Results identify PDE4B (show PDE4B Antibodies) in the CaV1.2 (show CACNA1C Antibodies) complex as a critical regulator of ICa during beta-AR stimulation and suggest that distinct PDE4 (show PDE4A Antibodies) subtypes are important for normal regulation of calcium-induced calcium release in cardiomyocytes.
Findings demonstrate that PDE4D and PDE4B (show PDE4B Antibodies) have specialized functions in mouse embryonic fibroblasts with PDE4B (show PDE4B Antibodies) controlling cAMP in a discrete subdomain near the plasma membrane.
In this article, we review the role of the cAMP signal transduction pathway in memory formation with a particular focus on the recent progress in PDE4D research
Aberrant DNA methylation (show HELLS Antibodies) of PDE4D promoter alters airway smooth muscle cell phenotypes.
PDE4D interacts directly with Neuropilins, positive regulators of Hedgehog (show SHH Antibodies) signal transduction pathway.
results suggest that the rs918592 and rs2910829 polymorphisms and haplotypes of PDE4D gene are significantly associated with ischemic stroke in Chinese young population.
The increase in the C allele frequency at 87 single nucleotide polymorphism sites in PDE4D may increase ischemic stroke risk.
Critical residues stabilising PDE4D5 dimerization were defined within the regulatory UCR1 region found in long, but not short, PDE4 isoforms, namely the Arg(173), Asn(174) and Asn(175) (DD1) cluster.
These studies suggest the pharmacologic inhibition of PDE4D using small-molecule inhibitors is an effective option for prostate cancer therapy.
This result supports that PDE4D polymorphisms might be involved in the susceptibility to COPD (show ARCN1 Antibodies) especially in non-emphysematous individuals and that they could also affect the responsiveness of the PDE4 (show PDE4A Antibodies) inhibitor treatment.
structural analysis of the autoinhibited conformation of PDE4 (show PDE4A Antibodies)
The knockdown of PDE4D gene expression inhibited proliferation of STK11 (show STK11 Antibodies)-mutated lung cancer lines. Furthermore, challenge with a panel of PDE4 (show PDE4A Antibodies)-specific inhibitors was shown to selectively reduce the growth of STK11 (show STK11 Antibodies)-mutated lung cancer lines.
demonstrate the presence of PDE4D transcript and protein, but also show an active enzyme, suggesting a functional role of PDE4D in bovine mammary gland
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
phosphodiesterase E3 dunce homolog, Drosophila
, phosphodiesterase 4D, cAMP-specific
, cAMP-specific 3',5'-cyclic phosphodiesterase 4D-like
, phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
, cAMP-specific 3',5'-cyclic phosphodiesterase 4D
, cAMP-specific phosphodiesterase 4D
, cyclic AMP specific phosphodiesterase PDE4D5A
, cAMP-specific phosphodiesterase PDE4D6
, Phosphodiesterase 4D cAMP-specific (dunce
, Phosphodiesterase 4D, cAMP-specific (dunce
, cAMP-specific phosphodiesterase PDE4D
, cAMP-specific phosphodiesterase splice variant PDE4D8
, phosphodiesterase 4D, cAMP specific
, hypothetical protein