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phosphodiesterase 4D, CAMP-Specific Proteins (PDE4D)

PDE4D encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. Additionally we are shipping PDE4D Antibodies (85) and PDE4D Kits (25) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PDE4D 238871 Q01063
PDE4D 5144 Q08499
PDE4D 24627 P14270
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Top PDE4D Proteins at

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

PDE4D Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
Rat (Rattus)

Top referenced PDE4D Proteins

  1. Human PDE4D Protein expressed in Wheat germ - ABIN1314468 : Branham, Mayorga, Tomes: Calcium-induced acrosomal exocytosis requires cAMP acting through a protein kinase A-independent, Epac-mediated pathway. in The Journal of biological chemistry 2006 (PubMed)
    Show all 2 references for ABIN1314468

More Proteins for phosphodiesterase 4D, CAMP-Specific (PDE4D) Interaction Partners

Mouse (Murine) phosphodiesterase 4D, CAMP-Specific (PDE4D) interaction partners

  1. The authors demonstrate that the Attention Deficit Disorder with Hyperactivity phenotype depends on a dysregulation of CREB (show CREB1 Proteins) signaling exerted by a kinase-independent PI3Kgamma (show PIK3CG Proteins)-PDE4D interaction in the noradrenergic neurons of the locus coeruleus.

  2. SIK1 serves as a part of a self-regulatory circuit to modulate insulin (show INS Proteins) secretion from pancreatic beta-cells by controlling cAMP concentration through modulation of PDE4D activity.

  3. Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle, contributing to colonic dysmotility during inflammation.

  4. the loss of function of either DISC1 (show DISC1 Proteins) or ATF4 (show ATF4 Proteins) increases PDE4D9 transcription, and the association of DISC1 (show DISC1 Proteins) with the PDE4D9 locus requires ATF4 (show ATF4 Proteins)

  5. these results suggest that Pde4d might serve specific biological functions in regulating the development process of the mouse embryo, and that CpG methylation of the Pde4d promoter may play an important role in regulating Pde4d at a transcriptional level.

  6. Calcineurin (show PPP3CA Proteins) regulates degradation of phosphodiesterase 3B, in addition to phosphodiesterase 4D.

  7. Beta-arrestin-2 (show ARRB2 Proteins) scaffolding of phosphodiesterase PDE4D5 to the plasma membrane was required for TRPV1 (show TRPV1 Proteins) desensitization.

  8. Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2 (show CA2 Proteins)+ release and cardiac contractility, independently of L-type Ca2 (show CA2 Proteins)+ current.

  9. Results identify PDE4B (show PDE4B Proteins) in the CaV1.2 (show CACNA1C Proteins) complex as a critical regulator of ICa during beta-AR stimulation and suggest that distinct PDE4 (show PDE4A Proteins) subtypes are important for normal regulation of calcium-induced calcium release in cardiomyocytes.

  10. Findings demonstrate that PDE4D and PDE4B (show PDE4B Proteins) have specialized functions in mouse embryonic fibroblasts with PDE4B (show PDE4B Proteins) controlling cAMP in a discrete subdomain near the plasma membrane.

Human phosphodiesterase 4D, CAMP-Specific (PDE4D) interaction partners

  1. No association was found between single-nucleotide polymorphisms of ALOX5AP (show ALOX5AP Proteins) or PDE4D and the risk of overall ischemic stroke in a southeastern Chinese population.

  2. While prior studies have found an association between PDE4D and IL6R (show IL6R Proteins) polymorphisms and ischemic stroke, the results of this study suggest that this association may be different in a hypertensive population.

  3. This review show PDE4D mutation is a risk factor for atrial fibrillation and stroke.

  4. In this article, we review the role of the cAMP signal transduction pathway in memory formation with a particular focus on the recent progress in PDE4D research

  5. Aberrant DNA methylation (show HELLS Proteins) of PDE4D promoter alters airway smooth muscle cell phenotypes.

  6. PDE4D interacts directly with Neuropilins, positive regulators of Hedgehog (show SHH Proteins) signal transduction pathway.

  7. results suggest that the rs918592 and rs2910829 polymorphisms and haplotypes of PDE4D gene are significantly associated with ischemic stroke in Chinese young population.

  8. The increase in the C allele frequency at 87 single nucleotide polymorphism sites in PDE4D may increase ischemic stroke risk.

  9. Critical residues stabilising PDE4D5 dimerization were defined within the regulatory UCR1 region found in long, but not short, PDE4 isoforms, namely the Arg(173), Asn(174) and Asn(175) (DD1) cluster.

  10. These studies suggest the pharmacologic inhibition of PDE4D using small-molecule inhibitors is an effective option for prostate cancer therapy.

Cow (Bovine) phosphodiesterase 4D, CAMP-Specific (PDE4D) interaction partners

  1. demonstrate the presence of PDE4D transcript and protein, but also show an active enzyme, suggesting a functional role of PDE4D in bovine mammary gland

PDE4D Protein Profile

Protein Summary

This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.

Gene names and symbols associated with PDE4D

  • phosphodiesterase 4D, cAMP-specific (PDE4D)
  • phosphodiesterase 4D, cAMP-specific (pde4d)
  • phosphodiesterase 4D, cAMP specific (Pde4d)
  • phosphodiesterase 4D, cAMP-specific (Pde4d)
  • 9630011N22Rik protein
  • ACRDYS2 protein
  • DPDE3 protein
  • HSPDE4D protein
  • PDE4DN2 protein
  • PDE43 protein
  • STRK1 protein

Protein level used designations for PDE4D

phosphodiesterase E3 dunce homolog, Drosophila , phosphodiesterase 4D, cAMP-specific , cAMP-specific 3',5'-cyclic phosphodiesterase 4D-like , phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) , cAMP-specific 3',5'-cyclic phosphodiesterase 4D , cAMP-specific phosphodiesterase 4D , cyclic AMP specific phosphodiesterase PDE4D5A , dunce , cAMP-specific phosphodiesterase PDE4D6 , DPDE3 , Phosphodiesterase 4D cAMP-specific (dunce , Phosphodiesterase 4D, cAMP-specific (dunce , cAMP-specific phosphodiesterase PDE4D , cAMP-specific phosphodiesterase splice variant PDE4D8 , phosphodiesterase 4D, cAMP specific , hypothetical protein

100051344 Equus caballus
100032166 Monodelphis domestica
100406670 Callithrix jacchus
100496479 Xenopus (Silurana) tropicalis
100587050 Nomascus leucogenys
238871 Mus musculus
100302668 Cavia porcellus
5144 Homo sapiens
24627 Rattus norvegicus
769469 Gallus gallus
487221 Canis lupus familiaris
539556 Bos taurus
100351753 Oryctolagus cuniculus
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