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anti-phosphodiesterase 5A, CGMP-Specific (PDE5A) Antibodies

PDE5A encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. Additionally we are shipping phosphodiesterase 5A, CGMP-Specific Kits (10) and phosphodiesterase 5A, CGMP-Specific Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PDE5A 8654 O76074
PDE5A 242202 Q8CG03
PDE5A 171115 O54735
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Top anti-phosphodiesterase 5A, CGMP-Specific Antibodies at antibodies-online.com

Showing 10 out of 29 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated ELISA, WB ABIN185350 staining (0.3µg/ml) of human lung lysate (RIPA buffer, 30µg... 100 μg Log in to see 4 to 5 Days
$318.20
Details
Dog Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated IP, WB 0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Rat Mouse Un-conjugated IF, WB Western blot analysis of cGB-PDE on a rat lung lysate. Lane 1: 1:500, ... 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Mouse Un-conjugated IF, ELISA, WB Detection limit for recombinant GST tagged PDE5A is 1 ng/ml as a captu... Western Blot detection against Immunogen (37.84 KDa) . 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated IHC, WB Sample Type: Human placental tissue  Primary Antibody Dilution: 1:100S... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IP, WB   0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human cervical carcinoma labeled ... 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Mouse Un-conjugated ELISA   50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

PDE5A Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
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Mouse (Murine) , , , ,

Rat (Rattus) , , , ,
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Top referenced anti-phosphodiesterase 5A, CGMP-Specific Antibodies

  1. Human Polyclonal PDE5A Primary Antibody for IP, WB - ABIN493300 : Lin, Xin, Lin, Lue: Phosphodiesterases as therapeutic targets. in Urology 2003 (PubMed)
    Show all 3 references for ABIN493300

  2. Human Polyclonal PDE5A Primary Antibody for IP, WB - ABIN493302 : Rybalkin, Rybalkina, Feil, Hofmann, Beavo: Regulation of cGMP-specific phosphodiesterase (PDE5) phosphorylation in smooth muscle cells. in The Journal of biological chemistry 2002 (PubMed)
    Show all 3 references for ABIN493302

  3. Rat (Rattus) Monoclonal PDE5A Primary Antibody for IF, WB - ABIN968563 : Corbin, Francis: Cyclic GMP phosphodiesterase-5: target of sildenafil. in The Journal of biological chemistry 1999 (PubMed)
    Show all 3 references for ABIN968563

  4. Human Polyclonal PDE5A Primary Antibody for ELISA - ABIN563734 : Meyer, Sevko, Ramacher, Bazhin, Falk, Osen, Borrello, Kato, Schadendorf, Baniyash, Umansky: Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma model. in Proceedings of the National Academy of Sciences of the United States of America 2011 (PubMed)

  5. Human Monoclonal PDE5A Primary Antibody for IF, ELISA - ABIN563735 : Maharaj, OToole, Lynch, Carney, Jarman, Higgins, Morrison, Laffey: Effects and mechanisms of action of sildenafil citrate in human chorionic arteries. in Reproductive biology and endocrinology : RB&E 2009 (PubMed)

  6. Dog (Canine) Polyclonal PDE5A Primary Antibody for WB - ABIN374520 : Morelli, Filippi, Mancina, Luconi, Vignozzi, Marini, Orlando, Vannelli, Aversa, Natali, Forti, Giorgi, Jannini, Ledda, Maggi: Androgens regulate phosphodiesterase type 5 expression and functional activity in corpora cavernosa. in Endocrinology 2004 (PubMed)

More Antibodies against phosphodiesterase 5A, CGMP-Specific Interaction Partners

Cow (Bovine) phosphodiesterase 5A, CGMP-Specific (PDE5A) interaction partners

Human phosphodiesterase 5A, CGMP-Specific (PDE5A) interaction partners

  1. cGMP PDE (show ALDH7A1 Antibodies) isozymes, PDE5 and 10, are elevated in colon tumor cells compared with normal colonocytes, and inhibitors and siRNAs can selectively suppress colon tumor cell growth

  2. Results show that Ser102 and Ser104 may influence the conformational flexibility of PDE5A, which may in turn influence phosphorylation status, allosteric regulation by cGMP or other as yet unknown regulatory mechanisms for PDE5A.

  3. PDE5A appears to jointly influence amygdala volume and emotion recognition performance.

  4. inhibition of PDE5 can counteract apoptosis during aging by modulating proand antiapoptotic molecules and the APP (show APP Antibodies) pathway.

  5. Myocardial PDE5 expression is increased in the hearts of humans and mice with chronic pressure overload.

  6. it is concluded that assessment of PDE5 and PDE9 expression may be useful in the differential diagnosis of benign and malignant breast disease and successful treatment of breast cancer

  7. analysis of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6

  8. PDE5 is highly expressed and increases ( approximately 130%) during growth whereas ABCC5 (show ABCC5 Antibodies) exhibited low to moderate expression, with a moderate increase ( approximately 40%) during growth

  9. PDE9 is widely distributed in the urothelial epithelium of the human lower urinary tract and its potential roles may be different from those of PDE5.

  10. Treatment of L-1236 with PDE5A-inhibitor sildenafil or with siRNA directed against PDE5A and concomitant stimulation with cyclic guanosine monophosphate (cGMP) resulted in enhanced apoptosis, indicating PDE5A as an oncogene (show RAB1A Antibodies).

Mouse (Murine) phosphodiesterase 5A, CGMP-Specific (PDE5A) interaction partners

  1. Upon S-nitrosylation, PDE5 exhibits reduced activity and degradation via the ubiquitin-proteasome system.

  2. Short-term hemolysis is sufficient to establish a priapism phenotype and results in loss of erectile function. PDE5I treatment ameliorates priapism, in part, because of restored NO balance with decreased ROS (show ROS1 Antibodies) generation and increased PDE5 activity.

  3. Addition of sildenafil, a phosphodiesterase 5 (PDE5) inhibitor, in the drinking water had a small effect in reducing myocyte hypertrophy in wild type mice and no effect in betaRM mice.

  4. findings reveal that excess adenosine-mediated ADORA2B (show ADORA2B Antibodies) signaling underlies reduced penile PDE (show TWIST1 Antibodies) activity by decreasing PDE5 gene expression in a HIF-1alpha (show HIF1A Antibodies)-dependent manner

  5. Findings suggest that continuous, long-term treatment with PDE5 inhibitors reverses eNOS (show NOS3 Antibodies) uncoupling in the sickle cell penis which restores endothelial NO synthesis.

  6. Data indicate that the phosphodiesterase 5 (PDE5) expression is equal in the splenocytes from both genders, but splenocytes from female mice possess higher basal level of cGMP compared to the male ones.

  7. Myocardial PDE5 expression is increased in the hearts of humans and mice with chronic pressure overload.

  8. PDE5 inhibition did not alter atrial natriuretic peptide (show NPPA Antibodies)-stimulated cGMP in the resting heart but augmented it in the transaortic constriction heart.

  9. Sildenafil-mediated PDE5 inhibition significantly reduces diaphragm respiratory muscle dysfunction and pathology in the mdx (show DMD Antibodies) mouse model of Duchenne muscular dystrophy (show DMD Antibodies).

  10. these data strongly support a primary role of myocyte PDE5 regulation to myocardial pathobiology

Pig (Porcine) phosphodiesterase 5A, CGMP-Specific (PDE5A) interaction partners

  1. PDE5 inhibition and increase in cGMP produce pulmonary vasodilation that is mediated in part through inhibition of the ET pathway, thereby precluding an additional vasodilator effect of ETA/ETB (show EDNRB Antibodies) receptor blockade in the presence of PDE5 inhibition.

  2. PDE5 is a key regulator of NO-induced vasodilation in the postnatal pulmonary arteries.

phosphodiesterase 5A, CGMP-Specific (PDE5A) Antigen Profile

Protein Summary

This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms.

Gene names and symbols associated with PDE5A

  • phosphodiesterase 5A, cGMP-specific (PDE5A) antibody
  • phosphodiesterase 5a, cGMP-specific (pde5a) antibody
  • phosphodiesterase 5A, cGMP-specific, b (pde5ab) antibody
  • phosphodiesterase 5A, cGMP-specific (pde5a) antibody
  • phosphodiesterase 5A, cGMP-specific (Pde5a) antibody
  • phosphodiesterase isozyme 5 (PDE5) antibody
  • CGB-PDE antibody
  • Cgbpde antibody
  • CN5A antibody
  • Cn5n antibody
  • Pde5 antibody
  • pde5a antibody
  • Pde5a1 antibody
  • PDE5A2 antibody

Protein level used designations for PDE5A

CGB-PDE , cGMP-binding cGMP-specific phosphodiesterase , cGMP-specific 3',5'-cyclic phosphodiesterase , phosphodiesterase 5A, cGMP-specific , phosphodiesterase 5a, cGMP-specific , phosphodiesterase 5a , cGMP-specific 3',5'-cyclic phosphodiesterase-like , cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase , cGMP-specific phosphodiesterase PDE5A2 , cGMP-specific phosphodiesterase type 5A , phosphodiesterase isozyme 5 , cGMP-binding/cGMP-specific phosphodiesterase , cGMP-binding cGMP specific phosphodiesterase 5A2 , phosphodiesterase type 5 , 3',5'-Cyclic GMP Phosphodiesterase , cyclic nucleotide phosphodiesterase 5a

GENE ID SPECIES
100072395 Equus caballus
281972 Bos taurus
461461 Pan troglodytes
495103 Xenopus laevis
553270 Danio rerio
705592 Macaca mulatta
780273 Xenopus (Silurana) tropicalis
100391416 Callithrix jacchus
100446315 Pongo abelii
100482637 Ailuropoda melanoleuca
100495581 Xenopus (Silurana) tropicalis
100533976 Felis catus
100539087 Meleagris gallopavo
100560459 Anolis carolinensis
100581952 Nomascus leucogenys
8654 Homo sapiens
242202 Mus musculus
171115 Rattus norvegicus
403825 Canis lupus familiaris
785098 Bos taurus
422677 Gallus gallus
100527958 Cavia porcellus
397616 Sus scrofa
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