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phosphodiesterase 5A, CGMP-Specific Proteins (PDE5A)

PDE5A encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. Additionally we are shipping phosphodiesterase 5A, CGMP-Specific Antibodies (31) and phosphodiesterase 5A, CGMP-Specific Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PDE5A 8654 O76074
PDE5A 242202 Q8CG03
PDE5A 171115 O54735
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Top phosphodiesterase 5A, CGMP-Specific Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$365.64
Details
HOST_Escherichia coli (E. coli) Chicken Un-conjugated   5 applications Log in to see 1 to 2 Days
$344.14
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HOST_Escherichia coli (E. coli) Cow Un-conjugated   5 applications Log in to see 1 to 2 Days
$344.14
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PDE5A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for phosphodiesterase 5A, CGMP-Specific (PDE5A) Interaction Partners

Cow (Bovine) phosphodiesterase 5A, CGMP-Specific (PDE5A) interaction partners

Human phosphodiesterase 5A, CGMP-Specific (PDE5A) interaction partners

  1. Our data showed a significant and previously undocumented upregulation of PDE5 in both rat and human BPH (show GLI3 Proteins).

  2. Overexpression of PDE5 in papillary thyroid carcinomas.

  3. cGMP PDE (show ALDH7A1 Proteins) isozymes, PDE5 and 10, are elevated in colon tumor cells compared with normal colonocytes, and inhibitors and siRNAs can selectively suppress colon tumor cell growth

  4. Results show that Ser102 and Ser104 may influence the conformational flexibility of PDE5A, which may in turn influence phosphorylation status, allosteric regulation by cGMP or other as yet unknown regulatory mechanisms for PDE5A.

  5. PDE5A appears to jointly influence amygdala volume and emotion recognition performance.

  6. inhibition of PDE5 can counteract apoptosis during aging by modulating proand antiapoptotic molecules and the APP (show APP Proteins) pathway.

  7. Myocardial PDE5 expression is increased in the hearts of humans and mice with chronic pressure overload.

  8. it is concluded that assessment of PDE5 and PDE9 expression may be useful in the differential diagnosis of benign and malignant breast disease and successful treatment of breast cancer

  9. analysis of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6

  10. PDE5 is highly expressed and increases ( approximately 130%) during growth whereas ABCC5 (show ABCC5 Proteins) exhibited low to moderate expression, with a moderate increase ( approximately 40%) during growth

Mouse (Murine) phosphodiesterase 5A, CGMP-Specific (PDE5A) interaction partners

  1. Upon S-nitrosylation, PDE5 exhibits reduced activity and degradation via the ubiquitin-proteasome system.

  2. Short-term hemolysis is sufficient to establish a priapism phenotype and results in loss of erectile function. PDE5I treatment ameliorates priapism, in part, because of restored NO balance with decreased ROS (show ROS1 Proteins) generation and increased PDE5 activity.

  3. Addition of sildenafil, a phosphodiesterase 5 (PDE5) inhibitor, in the drinking water had a small effect in reducing myocyte hypertrophy in wild type mice and no effect in betaRM mice.

  4. findings reveal that excess adenosine-mediated ADORA2B (show ADORA2B Proteins) signaling underlies reduced penile PDE (show TWIST1 Proteins) activity by decreasing PDE5 gene expression in a HIF-1alpha (show HIF1A Proteins)-dependent manner

  5. Findings suggest that continuous, long-term treatment with PDE5 inhibitors reverses eNOS (show NOS3 Proteins) uncoupling in the sickle cell penis which restores endothelial NO synthesis.

  6. Data indicate that the phosphodiesterase 5 (PDE5) expression is equal in the splenocytes from both genders, but splenocytes from female mice possess higher basal level of cGMP compared to the male ones.

  7. Myocardial PDE5 expression is increased in the hearts of humans and mice with chronic pressure overload.

  8. PDE5 inhibition did not alter atrial natriuretic peptide (show NPPA Proteins)-stimulated cGMP in the resting heart but augmented it in the transaortic constriction heart.

  9. Sildenafil-mediated PDE5 inhibition significantly reduces diaphragm respiratory muscle dysfunction and pathology in the mdx (show DMD Proteins) mouse model of Duchenne muscular dystrophy (show DMD Proteins).

  10. these data strongly support a primary role of myocyte PDE5 regulation to myocardial pathobiology

Pig (Porcine) phosphodiesterase 5A, CGMP-Specific (PDE5A) interaction partners

  1. PDE5 inhibition and increase in cGMP produce pulmonary vasodilation that is mediated in part through inhibition of the ET pathway, thereby precluding an additional vasodilator effect of ETA/ETB (show EDNRB Proteins) receptor blockade in the presence of PDE5 inhibition.

  2. PDE5 is a key regulator of NO-induced vasodilation in the postnatal pulmonary arteries.

phosphodiesterase 5A, CGMP-Specific (PDE5A) Protein Profile

Protein Summary

This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms.

Gene names and symbols associated with PDE5A

  • phosphodiesterase 5A, cGMP-specific (PDE5A)
  • phosphodiesterase 5a, cGMP-specific (pde5a)
  • phosphodiesterase 5A, cGMP-specific, b (pde5ab)
  • phosphodiesterase 5A, cGMP-specific (pde5a)
  • phosphodiesterase 5A, cGMP-specific (Pde5a)
  • phosphodiesterase isozyme 5 (PDE5)
  • CGB-PDE protein
  • Cgbpde protein
  • CN5A protein
  • Cn5n protein
  • Pde5 protein
  • pde5a protein
  • Pde5a1 protein
  • PDE5A2 protein

Protein level used designations for PDE5A

CGB-PDE , cGMP-binding cGMP-specific phosphodiesterase , cGMP-specific 3',5'-cyclic phosphodiesterase , phosphodiesterase 5A, cGMP-specific , phosphodiesterase 5a, cGMP-specific , phosphodiesterase 5a , cGMP-specific 3',5'-cyclic phosphodiesterase-like , cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase , cGMP-specific phosphodiesterase PDE5A2 , cGMP-specific phosphodiesterase type 5A , phosphodiesterase isozyme 5 , cGMP-binding/cGMP-specific phosphodiesterase , cGMP-binding cGMP specific phosphodiesterase 5A2 , phosphodiesterase type 5 , 3',5'-Cyclic GMP Phosphodiesterase , cyclic nucleotide phosphodiesterase 5a

GENE ID SPECIES
100072395 Equus caballus
281972 Bos taurus
461461 Pan troglodytes
495103 Xenopus laevis
553270 Danio rerio
705592 Macaca mulatta
780273 Xenopus (Silurana) tropicalis
100391416 Callithrix jacchus
100446315 Pongo abelii
100482637 Ailuropoda melanoleuca
100495581 Xenopus (Silurana) tropicalis
100533976 Felis catus
100539087 Meleagris gallopavo
100560459 Anolis carolinensis
100581952 Nomascus leucogenys
8654 Homo sapiens
242202 Mus musculus
171115 Rattus norvegicus
403825 Canis lupus familiaris
785098 Bos taurus
422677 Gallus gallus
100527958 Cavia porcellus
397616 Sus scrofa
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