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phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A) ELISA Kits

PDE6A encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. Additionally we are shipping phosphodiesterase 6A, CGMP-Specific, Rod, alpha Antibodies (36) and phosphodiesterase 6A, CGMP-Specific, Rod, alpha Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human PDE6A PDE6A 5145 P16499
Anti-Mouse PDE6A PDE6A 225600  
Anti-Rat PDE6A PDE6A 307401  
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More ELISA Kits for phosphodiesterase 6A, CGMP-Specific, Rod, alpha Interaction Partners

Zebrafish phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A) interaction partners

Cow (Bovine) phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A) interaction partners

Human phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A) interaction partners

  1. report two splice acceptor site variations in PDE6A in consanguineous Pakistani families who manifested cardinal (show CARD8 ELISA Kits) symptoms of autosomal recessive retinitis pigmentosa

  2. analysis of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 (show PDE5A ELISA Kits) and PDE6

  3. the p.Val685Met mutation in PDE6A causes retinal degeneration in humans

  4. Rod phosphodiesterase-6 PDE6A and PDE6B (show PDE6B ELISA Kits) subunits are enzymatically equivalent.

  5. full transcriptional activity of the PDE6A gene requires both Nrl (show NRL ELISA Kits) and Crx (show CRX ELISA Kits)

Mouse (Murine) phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A) interaction partners

  1. Study confirms the severity of different Pde6a mutations and indicates that compound heterozygous mutants behave like intermediates of the respective homozygous situations homologous to a case of human retinitis pigmentosa.

  2. A new mutation in Pde6a was identifies in a mouse model of retinal degeneration.

  3. cGMP-phosphodiesterase 6 can be activated by another cancer-retina antigen, transducin (show GNAT1 ELISA Kits), through Wnt5a (show WNT5A ELISA Kits)-Frizzled-2 (show FZD2 ELISA Kits) cascade, which leads to a lowering of cGMP and an increase in intracellular calcium mobilization.

  4. AIPL1 (show AIPL1 ELISA Kits) interacts with the catalytic subunit (alpha) of PDE6 and is needed for the assembly of functional rod PDE6 subunits.

  5. full transcriptional activity of the PDE6A gene requires both Nrl (show NRL ELISA Kits) and Crx (show CRX ELISA Kits)

  6. missense mutations were found in the catalytic domain of the Pde6a gene in two mouse models from an ethyl nitrosourea chemical mutagenesis screen.

phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A) Antigen Profile

Antigen Summary

This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.

Gene names and symbols associated with PDE6A

  • phosphodiesterase 6A, cGMP-specific, rod, alpha (pde6a) antibody
  • phosphodiesterase 6A, cGMP-specific, rod, alpha (PDE6A) antibody
  • phosphodiesterase 6A, cGMP-specific, rod, alpha (Pde6a) antibody
  • CGPR-A antibody
  • nmf282 antibody
  • Pdea antibody
  • RP43 antibody
  • si:bz1d10.3 antibody
  • si:rp71-1d10.3 antibody

Protein level used designations for PDE6A

cGMP-specific , rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha , phosphodiesterase 6A, alpha subunit , phosphodiesterase 6A, cGMP-specific, rod, alpha , phosphodiesterase 6A-like , rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha-like , GMP-PDE alpha , PDE V-B1 , phosphodiesterase, cyclic GMP (rod receptor), alpha polypeptide , cGMP phosphodiesterase alpha subunit , rod photoreceptor cGMP phosphodiesterase alpha subunit , cGMP phosphodiesterase alpha , cGMP-phosphodiesterase alpha-subunit

GENE ID SPECIES
368410 Danio rerio
462184 Pan troglodytes
677688 Macaca mulatta
100028818 Monodelphis domestica
100342363 Oryctolagus cuniculus
100432609 Pongo abelii
100489913 Xenopus (Silurana) tropicalis
100596985 Nomascus leucogenys
281973 Bos taurus
101122024 Ovis aries
5145 Homo sapiens
225600 Mus musculus
307401 Rattus norvegicus
403620 Canis lupus familiaris
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