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phosphodiesterase 6B, CGMP-Specific, Rod, beta Proteins (PDE6B)

Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. Additionally we are shipping PDE6B Antibodies (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PDE6B 5158 P35913
PDE6B 289878  
PDE6B 18587 P23440
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Top PDE6B Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$365.64
Details
HOST_Escherichia coli (E. coli) Cow Un-conjugated   5 applications Log in to see 1 to 2 Days
$344.14
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PDE6B Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Rat (Rattus)
Mouse (Murine)

More Proteins for phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B) Interaction Partners

Human phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B) interaction partners

  1. Heterozygous mutation in the PDE6B gene can cause a reduction in the rod function to different degrees.

  2. Next-generation whole exome sequencing revealed a homozygous c.1923_1969ins6del47 nonsense PDE6B mutation, which has not been previously described, that segregated with the disease in the family.

  3. The family was found to segregate novel mutations of two different genes: myosin VIIA (MYO7A), and phosphodiesterase 6B, which causes nonsyndromic retinitis pigmentosa.

  4. analysis of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 (show PDE5A Proteins) and PDE6

  5. The p.H557Y mutation in PDE6B, was homozygous in four patients and heterozygous in nine patients, and it was the most frequent mutation (2.5%) in Korean patients with retinitis pigmentosa.

  6. Data indicate the upregulation of RREB1, PDE6B, and CD209 (show CD209 Proteins) suggests that these proteins might play important roles in the differentiation of primitive gut (show GUSB Proteins) tube cells from embryonic stem cells (hESCs) and in primitive gut (show GUSB Proteins) tube development into pancreas.

  7. Mutations have been identified in the beta-subunit (show POLG Proteins) of rod phosphodiesterase in consanguineous Pakistani families with autosomal recessive retinitis pigmentosa.

  8. Rod phosphodiesterase-6 PDE6A (show PDE6A Proteins) and PDE6B subunits are enzymatically equivalent.

  9. Sp4 is a strong activator of transcription (show STAT1 Proteins) from the beta-PDE (show ALDH7A1 Proteins) promoter

  10. the rod cGMP-phosphodiesterase beta-subunit gene is transcriptionally and post-transcriptionally regulated [review]

Cow (Bovine) phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B) interaction partners

Mouse (Murine) phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B) interaction partners

  1. demonstrated a substantial difference in the speed of retinal degeneration and accompanying loss of visual function between two rd1 lines

  2. transient and Pde6-independent Ca(2 (show CA2 Proteins)+) elevations ('flashes') were detected throughout the inner segment and the synapse.

  3. Polyglutamine expansion AR sequesters PTIP (show PAXIP1 Proteins) to attenuate DNA repair and increase genomic instability.

  4. There are distinct changes that occur in the morphology of retinal pigment epithelium cells in response to retinal degeneration in rd10 mice.

  5. that effective knockdown of GUCY2E and CNGA1 (show CNGA1 Proteins) expression to counteract loss of PDE6 function may develop into a valuable approach for treating some patients with RP.

  6. NC/Tnd mice also preserve the Pde6b(rd1) gene mutation resulting in the rapid postnatal retinal degeneration similar to that in C3H/HeN (show RPS6 Proteins) mice.

  7. Results describe the progression of neuronal remodeling of second- and third-order retinal cells and their synaptic terminals in retinas from Pde6b knockout mice at varying stages of degeneration.

  8. the degeneration of rd1 mouse retina is rescued by antioxidants and involves thiol-dependent metabolism

  9. The differential activation of Akt (show AKT1 Proteins) was studied in the photorceptors of normal and rd1 mice.

  10. These data demonstrate a correlation between genotype and phenotype. Four of the mutants with severe genetic lesions have rapid onset of retinal degeneration, as determined by fundus examination. These mice were indistinguishable from Pde6b(rd1) mice.

PDE6B Protein Profile

Protein Summary

Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PDE6B

  • phosphodiesterase 6B, cGMP-specific, rod, beta (PDE6B)
  • phosphodiesterase 6B, cGMP-specific, rod, beta (Pde6b)
  • phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide (Pde6b)
  • CSNB3 protein
  • CSNBAD2 protein
  • PDBS protein
  • Pdeb protein
  • r protein
  • RCD-1 protein
  • rd protein
  • rd-1 protein
  • rd1 protein
  • rd10 protein
  • RP40 protein

Protein level used designations for PDE6B

GMP-PDE beta , rod cGMP-phosphodiesterase beta-subunit , rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta , pde6B gene for cGMP phosphodiesterase beta subunit , phosphodiesterase 6B, cGMP-specific, rod, beta (congenital stationary night blindness 3, autosomal dominant) , rod cGMP phosphodiesterase beta subunit , phosphodiesterase, cyclic GMP ( rod receptor), beta polypeptide , phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide , cGMP-phosphodiesterase beta-subunit , phosphodiesterase, cGMP, rod receptor, beta polypeptide , retinal degeneration 1

GENE ID SPECIES
5158 Homo sapiens
399653 Canis lupus familiaris
281974 Bos taurus
289878 Rattus norvegicus
18587 Mus musculus
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