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The protein encoded by PDE9A catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. Additionally we are shipping PDE9A Proteins (11) and PDE9A Kits (2) and many more products for this protein.
Showing 10 out of 53 products:
Human Polyclonal PDE9A Primary Antibody for IP, WB - ABIN493326
Nakahara, Mueller, Nomizu, Yamada, Yeh, Chen: Activation of beta1 integrin signaling stimulates tyrosine phosphorylation of p190RhoGAP and membrane-protrusive activities at invadopodia. in The Journal of biological chemistry 1998
Show all 2 references for ABIN493326
Cow (Bovine) Polyclonal PDE9A Primary Antibody for IHC, WB - ABIN2782354
Huai, Wang, Zhang, Colman, Robinson, Ke: Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding. in Proceedings of the National Academy of Sciences of the United States of America 2004
Human Polyclonal PDE9A Primary Antibody for ICC, IF - ABIN4344458
Saito, Kitamura, Hijikata, Tomizawa-Murasawa, Tanaka, Takagi, Uchida, Suzuki, Sone, Najima, Ozawa, Wake, Taniguchi, Shultz, Ohara, Ishikawa: Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells. in Science translational medicine 2010
PDE9A can regulate cGMP signalling independent of the nitric oxide pathway, and its role in stress-induced heart disease suggests potential as a therapeutic target.
it is concluded that assessment of PDE5 (show PDE5A Antibodies) and PDE9 expression may be useful in the differential diagnosis of benign and malignant breast disease and successful treatment of breast cancer
In vivo effects of PDE9A inhibition included reversal of the respective disruptions of working memory.
PDE9 is widely distributed in the urothelial epithelium of the human lower urinary tract and its potential roles may be different from those of PDE5 (show PDE5A Antibodies).
Data show that PDE9A inhibitor, BAY-73-6691, significantly reduced basal and sickle cell (SCA) neutrophil adhesion; this was accompanied by decreased SCA neutrophil surface expressions of the L-selectin (show SELL Antibodies) and CD11b (show ITGAM Antibodies) adhesion molecules.
Identification and distribution of different variants produced by differential splicing of phosphodiesterase 9A mRNA.
The data suggests the utilization of two different start codons to produce a variety of different PDE9A proteins, allowing specific subcellular location of PDE9A splice variants.
PDE9A, is unlikely to play an important role in antidepressant outcome in this sample
The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene.
, phosphodiesterase 9a
, CGMP-specific 3',5'-cyclic phosphodiesterase type 9
, high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
, phosphodiesterase PDE9A21