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phosphoenolpyruvate Carboxykinase 1 (Soluble) Proteins (PCK1)

PCK1 is a main control point for the regulation of gluconeogenesis. Additionally we are shipping PCK1 Antibodies (193) and PCK1 Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PCK1 5105 P35558
PCK1 362282 P07379
PCK1 18534 Q9Z2V4
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Top PCK1 Proteins at antibodies-online.com

Showing 9 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$704.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$739.20
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,796.83
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$498.21
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PCK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Rat (Rattus)

Mouse (Murine)
,

Top referenced PCK1 Proteins

  1. Human PCK1 Protein expressed in Escherichia coli (E. coli) - ABIN668008 : Barthel, Schmoll: Novel concepts in insulin regulation of hepatic gluconeogenesis. in American journal of physiology. Endocrinology and metabolism 2003 (PubMed)
    Show all 2 references for ABIN668008

More Proteins for phosphoenolpyruvate Carboxykinase 1 (Soluble) (PCK1) Interaction Partners

Arabidopsis thaliana phosphoenolpyruvate Carboxykinase 1 (Soluble) (PCK1) interaction partners

  1. Arabidopsis uses two gluconeogenic gateways for organic acids to fuel seedling establishment, one is via PCK1, and a second via PPDK.

  2. Malate metabolism is important during dark-induced stomatal closure and that phosphoenolpyruvate carboxykinase (PEPCK) is involved in this process.

Human phosphoenolpyruvate Carboxykinase 1 (Soluble) (PCK1) interaction partners

  1. A mutation of PCK1 associated with Smith-Magenis Syndrome, cytosolic PEPCK (show PEPCK Proteins) deficiency and NMDA receptor glutamate (show GRIN1 Proteins) insensitivity.

  2. Insulin (show INS Proteins)-dependent translocation of FOXO1 (show FOXO1 Proteins) regulated transcriptional repression of PCK1 concomitant with the formation of the FOXO1 (show FOXO1 Proteins)-euchromatic histone-lysine N-methyltransferase2 (show DNMT1 Proteins) (EHMT2 (show EHMT2 Proteins)) complex and histone modifications of the PCK1 promoter region

  3. Lipopolysaccharide and monophosphoryl lipid A also up-regulated G6PC (show G6PC Proteins) and PCK1 transcript abundance in a TLR4 (show TLR4 Proteins)-dependent manner.

  4. The PCK1 tag-single nucleotide polymorphisms influenced insulin (show INS Proteins) resistance by interacting with plasma n-3 polyunsaturated fatty acids levels in metabolic syndrome patients.

  5. HCV core protein expression-mediated FOXO1 (show FOXO1 Proteins) activation and the increased PGC-1alpha leaded to the elevation of PCK1 at the mRNA level

  6. Acetylation regulates the stability of the gluconeogenic rate-limiting enzyme PEPCK1.

  7. Data show PEPCK-C and CPT-1 (show CPT1A Proteins) mRNAs are more abundant in non-tumoral tissues than in the tumoral counterpart, whereas the opposite occurred for the FAS (show FAS Proteins) gene.

  8. Studies demonstrate the association between PCK1 and smaller average brain volume.

  9. Study in the EYHS cohort failed to identify an association of PCK1 polymorphisms with obesity, physical activity, and fitness.

  10. crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding (show RND2 Proteins) site

Pig (Porcine) phosphoenolpyruvate Carboxykinase 1 (Soluble) (PCK1) interaction partners

  1. the renal proximal tubule, may require the remodeling of AUF1 (show HNRNPD Proteins) binding to the elements that mediate the rapid turnover of PEPCK (show PEPCK Proteins) mRNA

Cow (Bovine) phosphoenolpyruvate Carboxykinase 1 (Soluble) (PCK1) interaction partners

  1. Expression of cytosolic PEPCK (show PEPCK Proteins) mRNA is transiently increased during early lactation, indicating that enhanced hepatic gluconeogenesis during lactation may be tied to enhanced capacity for cytosolic formation of phosphoenolpyruvate.

Mouse (Murine) phosphoenolpyruvate Carboxykinase 1 (Soluble) (PCK1) interaction partners

  1. Silencing PCK1 or inhibiting its enzymatic activity slows the growth of tumor-repopulating cells in vitro and impedes tumorigenesis in vivo.

  2. PEPCK-M expression partially rescued defects in lipid metabolism, gluconeogenesis and TCA cycle function impaired by PEPCK-C deletion, while approximately 10% re-expression of PEPCK-C normalized most parameters.

  3. FAT/CD36 (show CD36 Proteins) regulates PEPCK (show PEPCK Proteins) in adipose tissue and that this could be secondary to reductions in lipolysis.

  4. PCB 126 blunted the forskolin-stimulated increase in phosphoenolpyruvate carboxykinase (PEPCK (show PEPCK Proteins)) mRNA levels.

  5. the role of IL-6 (show IL6 Proteins) signalling in adipose tissue during exercise

  6. there are multiple cytokine pathways by which inflammation inhibits PEPCK (show PEPCK Proteins) expression in adipose tissue which could contribute to the increased mobilization of fatty acids during inflammation

  7. Glucagon (show GCG Proteins) can also regulate Pck1 in the intestine, but not in the kidneys.

  8. Pck1 plays an important role in both the mammary gland adipocytes and epithelial cells during lactation

  9. Results suggest that HDAC3 (show HDAC3 Proteins) mediates NF-kappaB (show NFKB1 Proteins) activity to repress Pepck (show PEPCK Proteins) transcription.

  10. Results show the effect of miR (show MLXIP Proteins)-29a in counteracting insulin (show INS Proteins) action on PEPCK (show PEPCK Proteins) gene expression by primarily targeting PI3K and abrogating downstream insulin (show INS Proteins) signaling in HepG2 cells.

Maize/Corn (Zea mays) phosphoenolpyruvate Carboxykinase 1 (Soluble) (PCK1) interaction partners

  1. The regulatory properties of maize phosphoenolpyruvate carboxylase were significantly altered by site-directed mutagenesis of residues 226 through 232.

PCK1 Protein Profile

Protein Summary

This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized.

Gene names and symbols associated with PCK1

  • phosphoenolpyruvate carboxykinase [ATP] (PCK1)
  • Phosphoenolpyruvate carboxykinase (Pepck)
  • phosphoenolpyruvate carboxykinase 1 (soluble) (pck1)
  • phosphoenolpyruvate carboxykinase 1 (soluble) (PCK1)
  • Phosphoenolpyruvate carboxykinase, cytosolic (ppckc)
  • phosphoenolpyruvate carboxykinase 1 (soluble) (LOC100224850)
  • phosphoenolpyruvate carboxykinase 1 (soluble) (Pck1)
  • phosphoenolpyruvate carboxykinase 1, cytosolic (Pck1)
  • phosphoenolpyruvate carboxylase7 (pep7)
  • 143299_at protein
  • AI265463 protein
  • cb856 protein
  • cb924 protein
  • CG10924 protein
  • CG17725 protein
  • Dmel\\CG17725 protein
  • dPEPCK protein
  • Dromel_CG17725_FBtr0086701_pepck_mORF protein
  • fj93h11 protein
  • GTP protein
  • PCK protein
  • Pck-1 protein
  • PCK1 protein
  • Pepck protein
  • PEPCK-C protein
  • PEPCK1 protein
  • PEPCKC protein
  • PHOSPHOENOLPYRUVATE CARBOXYKINASE protein
  • phosphoenolpyruvate carboxykinase 1 protein
  • Ppc1C protein
  • PPCK1 protein
  • RATPEPCK protein
  • T28I19.150 protein
  • T28I19_150 protein
  • wu:fc51c05 protein
  • wu:fj93h11 protein
  • zgc:63869 protein

Protein level used designations for PCK1

CG17725-PA , CG17725-PB , Pepck-PA , Pepck-PB , Phosphoenolpyruvate-carboxykinase , phosphoenol pyruvate carboxykinase , phosphoenolpyruvate carboxy kinase , phosphoenolpyruvate carboxykinase , phosphoenolpyruvate carboxykinase, cytosolic , PEPCK , phosphoenolpyruvate carboxykinase 1 (soluble) , Phosphoenolpyruvate carboxykinase, cytosolic , Phosphoenolpyruvate carboxykinase 1 (soluble)-like , PEPCK-C , cytosolic phosphoenolpyruvate carboxykinase , phosphoenolpyruvate carboxykinase, cytosolic [GTP] , phosphoenolpyruvate carboxylase , PEP carboxykinase , phosphopyruvate carboxylase , phosphoenolpyruvate carboxykinase 1 variant 1 , phosphoenolpyruvate carboxykinase 1 variant 2 , phosphoenolpyruvate carboxykinase 1 variant 3 , phosphoenolpyruvate carboxykinase 1 variant 4 , phosphoenolpyruvate carboxykinase 1 variant 5 , phosphoenolpyruvate carboxykinase (GTP) , phosphoenolpyruvate carboxykinase 1, cytosolic , phosphoenolpyruvate carboxykinase, cytosolic (GTP) , gluconeogenic enzyme , CL1793_1 , CL1793_1_ov , Ppc1 , pMR15 , pep*-pepcZm2A , pep8 , synonymous gene name: Pep2 in maize linkage map

GENE ID SPECIES
829943 Arabidopsis thaliana
37131 Drosophila melanogaster
378727 Danio rerio
379637 Xenopus laevis
696207 Macaca mulatta
100195420 Salmo salar
100224850 Taeniopygia guttata
100355682 Oryctolagus cuniculus
100634531 Amphimedon queenslandica
396458 Gallus gallus
5105 Homo sapiens
100144531 Sus scrofa
282855 Bos taurus
362282 Rattus norvegicus
403560 Canis lupus familiaris
18534 Mus musculus
542479 Zea mays
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