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PEPCK encodes a member of the phosphoenolpyruvate carboxykinase (GTP) family. Additionally we are shipping PEPCK Kits (17) and PEPCK Proteins (3) and many more products for this protein.
Showing 10 out of 71 products:
Cow (Bovine) Polyclonal PEPCK Primary Antibody for EIA, WB - ABIN374610
Méndez-Lucas, Duarte, Sunny, Satapati, He, Fu, Bermúdez, Burgess, Perales: PEPCK-M expression in mouse liver potentiates, not replaces, PEPCK-C mediated gluconeogenesis. in Journal of hepatology 2013
Show all 4 references for ABIN374610
Human Polyclonal PEPCK Primary Antibody for EIA, IHC (p) - ABIN360567
Modaressi, Brechtel, Christ, Jungermann: Human mitochondrial phosphoenolpyruvate carboxykinase 2 gene. Structure, chromosomal localization and tissue-specific expression. in The Biochemical journal 1998
Show all 3 references for ABIN360567
Human Polyclonal PEPCK Primary Antibody for ELISA, WB - ABIN185483
Duplus, Benelli, Reis, Fouque, Velho, Forest: Expression of phosphoenolpyruvate carboxykinase gene in human adipose tissue: induction by rosiglitazone and genetic analyses of the adipocyte-specific region of the promoter in type 2 diabetes. in Biochimie 2004
Show all 2 references for ABIN185483
Miscanthus giganteus Polyclonal PEPCK Primary Antibody for WB - ABIN249350
Aragón, Pascual, González, Escalona, Carvalho, Amancio: The physiology of ex vitro pineapple (Ananas comosus L. Merr. var MD-2) as CAM or C3 is regulated by the environmental conditions: proteomic and transcriptomic profiles. in Plant cell reports 2013
Silencing PCK1 (show PCK1 Antibodies) or inhibiting its enzymatic activity slows the growth of tumor-repopulating cells in vitro and impedes tumorigenesis in vivo.
Amino acid limitation and ER stress inducers, conditions that activate the amino acid response (AAR) and the unfolded protein response (UPR), stimulate PCK2 gene transcription in tumor cell lines.
PEPCK-M expression partially rescued defects in lipid metabolism, gluconeogenesis and TCA cycle function impaired by PEPCK-C deletion, while approximately 10% re-expression of PEPCK-C normalized most parameters.
FAT/CD36 (show CD36 Antibodies) regulates PEPCK in adipose tissue and that this could be secondary to reductions in lipolysis.
PCB (show PC Antibodies) 126 blunted the forskolin-stimulated increase in phosphoenolpyruvate carboxykinase (PEPCK) mRNA levels.
the role of IL-6 (show IL6 Antibodies) signalling in adipose tissue during exercise
there are multiple cytokine pathways by which inflammation inhibits PEPCK expression in adipose tissue which could contribute to the increased mobilization of fatty acids during inflammation
Glucagon (show GCG Antibodies) can also regulate Pck1 (show PCK1 Antibodies) in the intestine, but not in the kidneys.
Pck1 (show PCK1 Antibodies) plays an important role in both the mammary gland adipocytes and epithelial cells during lactation
Results suggest that HDAC3 (show HDAC3 Antibodies) mediates NF-kappaB (show NFKB1 Antibodies) activity to repress Pepck transcription.
ApoA-IV (show APOA4 Antibodies) colocalizes with NR4A1 (show NR4A1 Antibodies), which suppresses G6Pase (show G6PC Antibodies) and PEPCK gene expression at the transcriptional level, reducing hepatic glucose output and lowering blood glucose.
Results indicate that PEPCK promotes tumor growth by increasing glucose and glutamine (show GFPT1 Antibodies) metabolism, increases anabolic metabolism and promotes mTORC1 activity.
Mitochondrial PCK2 regulates metabolic adaptation and enables glucose-independent tumor growth in various neoplasms.
When autophagy was blocked, the level of glucose-6-phosphatase (G6Pase (show G6PC Antibodies)) and phosphoenolpyruvate carboxykinase (PEPCK) was reduced in HepG2 cells and not in Hep3B cells.
PEPCK activity was elevated threefold in lung cancer samples over normal lungs and its activation mediates an adaptive response to glucose depletion in lung cancer.
Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells.
expression of HCV nonstructural component NS5A in Huh7 or primary hepatocytes stimulated PEPCK gene expression and glucose output in HepG2 cells.
results reveal a novel link between glucose metabolism and the DNA damage signaling pathway and suggest a possible role for PEPCK and G6P in the DNA damage response
Endoplasmic reticulum stress triggers suppression of AMPK (show PRKAA1 Antibodies) while increasing C/EBPbeta (show CEBPB Antibodies) and pCREB expression which activates PEPCK gene transcription.
Transition to lactation does not alter expression of the mitochondrial form of PEPCK.
Concurrent binding and modifications of AUF1 (show HNRNPD Antibodies) and HuR (show ELAVL1 Antibodies) mediate the pH-responsive stabilization of phosphoenolpyruvate carboxykinase mRNA in kidney cells.
This gene encodes a member of the phosphoenolpyruvate carboxykinase (GTP) family. The protein is a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of GTP. A cytosolic form encoded by a different gene has also been characterized and is the key enzyme of gluconeogenesis in the liver. The encoded protein may serve a similar function, although it is constitutively expressed and not modulated by hormones such as glucagon and insulin that regulate the cytosolic form. Alternatively spliced transcript variants have been described.
phosphoenolpyruvate carboxykinase [GTP], mitochondrial
, mitochondrial phosphoenolpyruvate carboxykinase 2
, phosphoenolpyruvate carboxylase
, phosphoenolpyruvate carboxykinase
, Phosphoenolpyruvate carboxylase
, PEP carboxykinase
, phosphoenolpyruvate carboxykinase [ATP]
, phosphoenolpyruvate carboxykinase, cytosolic
, phosphoenolpyruvate carboxykinase, cytosolic [GTP]
, phosphopyruvate carboxylase