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anti-phosphoenolpyruvate Carboxykinase 2 (Mitochondrial) (PEPCK) Antibodies

PEPCK encodes a member of the phosphoenolpyruvate carboxykinase (GTP) family. Additionally we are shipping PEPCK Kits (17) and PEPCK Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PEPCK 18534 Q9Z2V4
PEPCK 5106 Q16822
PEPCK 361042  
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Top anti-PEPCK Antibodies at antibodies-online.com

Showing 10 out of 76 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Goat Un-conjugated ELISA, WB ABIN185483 (0.5µg/ml) staining of human liver lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Cow Goat Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Western blot analysis of anti-PCK2 Antibody (N-term) (ABIN392678) in HepG2 cell line lysates (35 µg/lane). PCK2 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image PCK2 antibody [C1C2], Internal detects PCK2 protein by Western blot analysis. A. 30 µg HepG2 whole cell lysate/extract 7.5 % SDS-PAGE PCK2 antibody [C1C2], Internal , dilution: 1:1000 WB Image PCK2 antibody [C1C2], Internal detects PCK2 protein by Western blot analysis. A. 30 µg Neuro2A whole cell lysate/extract B. 30 µg GL261 whole cell lysate/extract 7.5 % SDS-PAGE PCK2 antibody [C1C2], Internal , dilution: 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Guinea Pig Goat Un-conjugated ELISA, WB ABIN250823 (0.5ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. 0.1 mg Log in to see 5 to 7 Days
$427.88
Details
Miscanthus giganteus Rabbit Un-conjugated WB From left to right: Arabidopsis thaliana (1), Phaseaolus vulgaris (2), Zea mays (3), Miscantus giganteus (4), Panicum virgatum (5),Spartina alterniflora (6),Spartina patens (7), (20 ug of total cellular protein was loaded per lane) 200 μL Log in to see 5 to 6 Days
$467.78
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat liver labeled with Anti-PCK2 Polyclonal Antibody, Unconjugated (ABIN708206) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

PEPCK Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,
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Top referenced anti-PEPCK Antibodies

  1. Cow (Bovine) Polyclonal PEPCK Primary Antibody for EIA, WB - ABIN374610 : Méndez-Lucas, Duarte, Sunny, Satapati, He, Fu, Bermúdez, Burgess, Perales: PEPCK-M expression in mouse liver potentiates, not replaces, PEPCK-C mediated gluconeogenesis. in Journal of hepatology 2013 (PubMed)
    Show all 4 references for ABIN374610

  2. Human Polyclonal PEPCK Primary Antibody for EIA, IHC (p) - ABIN360567 : Modaressi, Brechtel, Christ, Jungermann: Human mitochondrial phosphoenolpyruvate carboxykinase 2 gene. Structure, chromosomal localization and tissue-specific expression. in The Biochemical journal 1998 (PubMed)
    Show all 3 references for ABIN360567

  3. Guinea Pig Polyclonal PEPCK Primary Antibody for ELISA, WB - ABIN250823 : Zhou, Li, Qi, Zhang, Zhang, Wu, Hu, Wu, Liu, Yan, Jing, Liu, Zhai: Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity. in Diabetologia 2012 (PubMed)
    Show all 2 references for ABIN250823

  4. Human Polyclonal PEPCK Primary Antibody for ELISA, WB - ABIN185483 : Duplus, Benelli, Reis, Fouque, Velho, Forest: Expression of phosphoenolpyruvate carboxykinase gene in human adipose tissue: induction by rosiglitazone and genetic analyses of the adipocyte-specific region of the promoter in type 2 diabetes. in Biochimie 2004 (PubMed)
    Show all 2 references for ABIN185483

  5. Miscanthus giganteus Polyclonal PEPCK Primary Antibody for WB - ABIN249350 : Aragón, Pascual, González, Escalona, Carvalho, Amancio: The physiology of ex vitro pineapple (Ananas comosus L. Merr. var MD-2) as CAM or C3 is regulated by the environmental conditions: proteomic and transcriptomic profiles. in Plant cell reports 2013 (PubMed)

More Antibodies against PEPCK Interaction Partners

Mouse (Murine) phosphoenolpyruvate Carboxykinase 2 (Mitochondrial) (PEPCK) interaction partners

  1. Lactate maintains/induces populations of postnatal neuronal progenitors/neural stem cells in a PEPCK-M-dependent manner

  2. Silencing PCK1 (show PCK1 Antibodies) or inhibiting its enzymatic activity slows the growth of tumor-repopulating cells in vitro and impedes tumorigenesis in vivo.

  3. Amino acid limitation and ER stress inducers, conditions that activate the amino acid response (AAR) and the unfolded protein response (UPR), stimulate PCK2 gene transcription in tumor cell lines.

  4. PEPCK-M expression partially rescued defects in lipid metabolism, gluconeogenesis and TCA cycle function impaired by PEPCK-C deletion, while approximately 10% re-expression of PEPCK-C normalized most parameters.

  5. FAT/CD36 (show CD36 Antibodies) regulates PEPCK in adipose tissue and that this could be secondary to reductions in lipolysis.

  6. PCB (show PC Antibodies) 126 blunted the forskolin-stimulated increase in phosphoenolpyruvate carboxykinase (PEPCK) mRNA levels.

  7. the role of IL-6 (show IL6 Antibodies) signalling in adipose tissue during exercise

  8. there are multiple cytokine pathways by which inflammation inhibits PEPCK expression in adipose tissue which could contribute to the increased mobilization of fatty acids during inflammation

  9. Glucagon (show GCG Antibodies) can also regulate Pck1 (show PCK1 Antibodies) in the intestine, but not in the kidneys.

  10. Pck1 (show PCK1 Antibodies) plays an important role in both the mammary gland adipocytes and epithelial cells during lactation

Human phosphoenolpyruvate Carboxykinase 2 (Mitochondrial) (PEPCK) interaction partners

  1. ApoA-IV (show APOA4 Antibodies) colocalizes with NR4A1 (show NR4A1 Antibodies), which suppresses G6Pase (show G6PC Antibodies) and PEPCK gene expression at the transcriptional level, reducing hepatic glucose output and lowering blood glucose.

  2. Results indicate that PEPCK promotes tumor growth by increasing glucose and glutamine (show GFPT1 Antibodies) metabolism, increases anabolic metabolism and promotes mTORC1 activity.

  3. Mitochondrial PCK2 regulates metabolic adaptation and enables glucose-independent tumor growth in various neoplasms.

  4. When autophagy was blocked, the level of glucose-6-phosphatase (G6Pase (show G6PC Antibodies)) and phosphoenolpyruvate carboxykinase (PEPCK) was reduced in HepG2 cells and not in Hep3B cells.

  5. PEPCK activity was elevated threefold in lung cancer samples over normal lungs and its activation mediates an adaptive response to glucose depletion in lung cancer.

  6. Amino acid limitation and ER stress inducers, conditions that activate the amino acid response (AAR) and the unfolded protein response (UPR), stimulate PCK2 gene transcription in tumor cell lines.

  7. Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells.

  8. expression of HCV nonstructural component NS5A in Huh7 or primary hepatocytes stimulated PEPCK gene expression and glucose output in HepG2 cells.

  9. results reveal a novel link between glucose metabolism and the DNA damage signaling pathway and suggest a possible role for PEPCK and G6P in the DNA damage response

  10. Endoplasmic reticulum stress triggers suppression of AMPK (show PRKAA1 Antibodies) while increasing C/EBPbeta (show CEBPB Antibodies) and pCREB expression which activates PEPCK gene transcription.

Cow (Bovine) phosphoenolpyruvate Carboxykinase 2 (Mitochondrial) (PEPCK) interaction partners

  1. Transition to lactation does not alter expression of the mitochondrial form of PEPCK.

Pig (Porcine) phosphoenolpyruvate Carboxykinase 2 (Mitochondrial) (PEPCK) interaction partners

  1. Concurrent binding and modifications of AUF1 (show HNRNPD Antibodies) and HuR (show ELAVL1 Antibodies) mediate the pH-responsive stabilization of phosphoenolpyruvate carboxykinase mRNA in kidney cells.

PEPCK Antigen Profile

Protein Summary

This gene encodes a member of the phosphoenolpyruvate carboxykinase (GTP) family. The protein is a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of GTP. A cytosolic form encoded by a different gene has also been characterized and is the key enzyme of gluconeogenesis in the liver. The encoded protein may serve a similar function, although it is constitutively expressed and not modulated by hormones such as glucagon and insulin that regulate the cytosolic form. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with PEPCK

  • phosphoenolpyruvate carboxykinase 2 (mitochondrial) (PCK2) antibody
  • phosphoenolpyruvate carboxykinase 2 (mitochondrial) (pck2) antibody
  • phosphoenolpyruvate carboxylase (pepc) antibody
  • phosphoenolpyruvate carboxylase (pepC) antibody
  • ppc (ppc) antibody
  • phosphoenolpyruvate carboxykinase (pck) antibody
  • phosphoenolpyruvate carboxylase (SCO3127) antibody
  • phosphoenolpyruvate carboxylase (ppc) antibody
  • PEPCase; PEPC (ppc) antibody
  • ATP (pck) antibody
  • Phosphoenolpyruvate carboxylase (Krad_3372) antibody
  • predicted phosphoenolpyruvate carboxykinase (pck) antibody
  • phosphoenolpyruvate carboxylase (Franean1_6583) antibody
  • phosphoenolpyruvate carboxykinase (LOC541622) antibody
  • phosphoenolpyruvate carboxykinase 1, cytosolic (Pck1) antibody
  • phosphoenolpyruvate carboxykinase 2 (mitochondrial) (Pck2) antibody
  • 1810010O14Rik antibody
  • 9130022B02Rik antibody
  • AI265463 antibody
  • id:ibd5157 antibody
  • pck antibody
  • Pck-1 antibody
  • pckA antibody
  • pepC antibody
  • PEPCK antibody
  • PEPCK-M antibody
  • PEPCK2 antibody
  • ppc antibody
  • SCE66.06c antibody
  • VF2478 antibody
  • zgc:77867 antibody

Protein level used designations for PEPCK

phosphoenolpyruvate carboxykinase [GTP], mitochondrial , mitochondrial phosphoenolpyruvate carboxykinase 2 , phosphoenolpyruvate carboxylase , phosphoenolpyruvate carboxykinase , Phosphoenolpyruvate carboxylase , PEP carboxykinase , PEPCK , phosphoenolpyruvate carboxykinase [ATP] , PEPCK-C , phosphoenolpyruvate carboxykinase, cytosolic , phosphoenolpyruvate carboxykinase, cytosolic [GTP] , phosphopyruvate carboxylase

GENE ID SPECIES
100054903 Equus caballus
406473 Danio rerio
452807 Pan troglodytes
543328 Triticum aestivum
994443 Streptococcus pyogenes MGAS8232
1022839 Bifidobacterium longum NCC2705
1032110 Corynebacterium efficiens YS-314
1098561 Streptomyces coelicolor A3(2)
1108462 Nostoc sp. PCC 7120
1210703 Streptomyces avermitilis MA-4680
1731756 Synechococcus sp. WH 8102
1791970 Rhodopirellula baltica SH 1
2649924 Corynebacterium diphtheriae NCTC 13129
3130488 Haloarcula marismortui ATCC 43049
3277758 Vibrio fischeri ES114
3345234 Corynebacterium glutamicum ATCC 13032
3430655 Haemophilus influenzae 86-028NP
3432866 Corynebacterium jeikeium K411
3958242 Desulfitobacterium hafniense Y51
4086128 Pseudomonas entomophila L48
4194418 Haloquadratum walsbyi DSM 16790
4716199 Yersinia enterocolitica subsp. enterocolitica 8081
4848495 Actinobacillus pleuropneumoniae serovar 5b str. L20
5336474 Kineococcus radiotolerans SRS30216
5391795 Clostridium kluyveri DSM 555
5674898 Frankia sp. EAN1pec
6062153 Escherichia coli str. K-12 substr. DH10B
6221982 Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'
541622 Zea mays
18534 Mus musculus
5106 Homo sapiens
74551 Mus musculus
361042 Rattus norvegicus
282856 Bos taurus
480255 Canis lupus familiaris
403165 Sus scrofa
396457 Gallus gallus
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