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PACS1 encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Additionally we are shipping and many more products for this protein.
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Clinical description of the PACS1-related syndrome has been reported in 19 unrelated patients.
PACS1 plays an important role in protein sorting for amyloidogenic-burden control via both SORLA (show SORL1 Antibodies)-dependent and SORLA (show SORL1 Antibodies)-independent mechanisms.
Our findings suggest that PACS1 is necessary for the formation of craniofacial structures and that perturbation of its functions results in a specific syndromic ID phenotype.
PACS-1 along with HIV-1 nef, has a role in downregulating cell surface MHC (show HLAE Antibodies)-I to the trans-Golgi network and usurping the ARF6 (show ARF6 Antibodies) endocytic pathway
subcellular localization and function of polycystin-2 (show PKD2 Antibodies) are directed by phosphofurin acidic cluster sorting protein (PACS)-1 and PACS-2 (show PACS2 Antibodies)
casein kinase 2 induces PACS-1 binding of nephrocystin (show NPHP1 Antibodies) and targeting to cilia
CK2 (show CSNK2A1 Antibodies)-activated phosphorylation cascade controlling PACS-1- and GGA3 (show GGA3 Antibodies)-mediated CI-MPR (show IGF2R Antibodies) sorting, is reported.
PACS-1 mediates phosphorylation-dependent ciliary trafficking of the CNGB1b (show CNGB1 Antibodies) in olfactory sensory neurons.
This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance.
, cytosolic sorting protein PACS-1