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Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. Additionally we are shipping PACS2 Proteins (4) and many more products for this protein.
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Human Polyclonal PACS2 Primary Antibody for IHC (p), WB - ABIN657066
Myhill, Lynes, Nanji, Blagoveshchenskaya, Fei, Carmine Simmen, Cooper, Thomas, Simmen: The subcellular distribution of calnexin is mediated by PACS-2. in Molecular biology of the cell 2008
Show all 2 references for ABIN657066
Human Polyclonal PACS2 Primary Antibody for IHC, IHC (p) - ABIN4343360
Aslan, You, Williamson, Endig, Youker, Thomas, Shu, Du, Milewski, Brush, Possemato, Sprott, Fu, Greis, Runckel, Vogel, Thomas: Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis. in Molecular cell 2009
cIAPs constitutively downregulate PACS-2 by polyubiquitination and proteasomal degradation, thereby restraining TRAIL-induced killing of liver cancer cells
Tumor necrosis factor (show TNF Antibodies)-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2.
subcellular localization and function of polycystin-2 (show PKD2 Antibodies) are directed by phosphofurin acidic cluster sorting protein (PACS)-1 (show PACS1 Antibodies) and PACS-2
PACS-2 as a novel sorting protein that links the endoplasmic reticulum (ER)-mitochondria axis to ER homeostasis
PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN (show TG Antibodies)/endosomal system
the phosphorylation state of the calnexin (show CANX Antibodies) cytosolic domain and its interaction with PACS-2 sort the chaperone between domains of the ER and the plasma membrane
Results identify PACS-2 as an essential TRAIL effector, and show that Akt (show AKT1 Antibodies) cooperates with 14-3-3 (show YWHAQ Antibodies) to regulate the homeostatic and apoptotic properties of PACS-2 that mediate TRAIL action.
CS-2 (show MYOZ1 Antibodies) traffics to the nucleus where it regulates SIRT1 (show SIRT1 Antibodies)-mediated p53 (show TP53 Antibodies) deacetylation. PACS-2 binds SIRT1 (show SIRT1 Antibodies) in vitro and directly inhibits SIRT1 (show SIRT1 Antibodies)-catalyzed p53 (show TP53 Antibodies) deacetylation.
Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.