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phosphoglycerate Dehydrogenase Proteins (PHGDH)

PHGDH encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. Additionally we are shipping PHGDH Antibodies (115) and PHGDH Kits (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PHGDH 236539 Q61753
PHGDH 26227 O43175
PHGDH 58835 O08651
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Top PHGDH Proteins at antibodies-online.com

Showing 9 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human GST tag phosphoglycerate Dehydrogenase (PHGDH) (AA 2-251), (partial) protein (GST tag) 1 mg Log in to see 56 to 66 Days
$1,842.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,518.17
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$310.00
Details
HOST_Sf-9 Cells Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$460.85
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PHGDH Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
,
Rat (Rattus)

Top referenced PHGDH Proteins

  1. Human PHGDH Protein expressed in Escherichia coli (E. coli) - ABIN2005507 : Pind, Slominski, Mauthe, Pearlman, Swoboda, Wilkins, Sauder, Natowicz: V490M, a common mutation in 3-phosphoglycerate dehydrogenase deficiency, causes enzyme deficiency by decreasing the yield of mature enzyme. in The Journal of biological chemistry 2002 (PubMed)

More Proteins for phosphoglycerate Dehydrogenase (PHGDH) Interaction Partners

Arabidopsis thaliana phosphoglycerate Dehydrogenase (PHGDH) interaction partners

  1. PGDH1 (show HPGD Proteins) is essential for Arabidopsis development.

  2. Genetic and molecular evidence were provided for the essential role of EDA9 for embryo and pollen development.

  3. Data indicate that 3-phosphoglycerate dehydrogenases PGDH (show HPGD Proteins) (At1g17745) and EDA9 (At4g34200) were expressed preferentially in roots while 3-PGDH (At3g19480) was expressed mainly in the aerial parts and was not expressed or very poorly in roots.

Mouse (Murine) phosphoglycerate Dehydrogenase (PHGDH) interaction partners

  1. These results indicate that the PHGDH gene expression, dictated by IL-2R signaling, is a crucial event for DNA synthesis during S phase of activated T cells.

  2. Using transgenic mice expressing enhanced GFP under the Srr (show SRR Proteins) promoter and mice with targeted deletion of Srr (show SRR Proteins) or 3-Phosphoglycerate dehydrogenase, we demonstrate predominantly neuronal sources of d-serine dependent on astrocytic supply of l-serine.

  3. Elevated levels of 4E-BP1 (show EIF4EBP1 Proteins) may be involved in a mechanism to arrest brain development in Phgdh knock out embryos.

  4. Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of brain D-serine, an N-methyl-D-aspartate receptor (show GRIN1 Proteins) co-agonist

  5. Data suggest expression of Phgdh in endometrium is regulated by Hoxa10.

  6. the Phgdh-dependent phosphorylated pathway is essential for normal embryonic development, especially for brain morphogenesis

  7. the presence of cis (show CISH Proteins)-acting elements confer the cell type specificity of Phgdh transcription in the distal promoter region.

  8. The mouse Phgdh gene spans approximately 27 kilobases in length and comprises 12 exons with 11 intervening introns and is mapped to chromosome 3, region F2-F3 by FISH.

  9. either Phgdh or ASCT1 (show SLC1A4 Proteins) is provided to each segment of renal tubules, suggesting that metabolic interplay mediated by L-serine biosynthesis and supply may exist in the kidney

  10. Inactivation of Phgdh gene with changes in gene expression and associated regulatory networks resulting from serine deficiency are reported.

Human phosphoglycerate Dehydrogenase (PHGDH) interaction partners

  1. Overexpression of Phgdh may be generally associated with CK5 (show KRT5 Proteins) cells, and oncogenic function may be determined by isoform expression.

  2. High expression of PHGDH is associated with Colon Cancer.

  3. p53 (show TP53 Proteins)-mediated repression of PHGDH enhances the apoptotic response upon serine starvation in melanoma cells.

  4. Phosphoglycerate Dehydrogenase deficiency is associated with Neu-Laxova syndrome.

  5. We report on the identification of homozygous mutations in PHGDH and serine deficiency in individuals with Neu (show ERBB2 Proteins)-Laxova syndrome. This disorder thus seems to be an extremely severe expression of PHGDH deficiency.

  6. PHGDH overexpression is found in cervical cancer, in particular, in bigger tumors and with advanced stages. Its expression is positively correlated with squamous cell carcinoma antigen level

  7. The potential mechanisms by which PHGDH promotes cancer are discussed.

  8. in some cancer cells a relatively large amount of glycolytic carbon is diverted into serine and glycine metabolism through phosphoglycerate dehydrogenase.

  9. results reveal that certain breast cancers are dependent upon increased serine pathway flux caused by PHGDH overexpression and demonstrate the utility of in vivo negative-selection RNAi screens for finding potential anticancer targets

  10. The crystal structure of Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase has been solved with bound effector, 1-serine, and substrate, hydroxypyruvic acid phosphate. The human enzyme was also examined.

PHGDH Protein Profile

Protein Summary

This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known.

Gene names and symbols associated with PHGDH

  • phosphoglycerate dehydrogenase (phgdh)
  • D-3-phosphoglycerate dehydrogenase (EDA9)
  • D-3-phosphoglycerate dehydrogenase (serA)
  • D-3-phosphoglycerate dehydrogenase (Sthe_2284)
  • D-3-phosphoglycerate dehydrogenase (Dacet_1260)
  • D-3-phosphoglycerate dehydrogenase (Mrub_0173)
  • D-3-phosphoglycerate dehydrogenase (Mmah_1539)
  • D-3-phosphoglycerate dehydrogenase (Arnit_0487)
  • D-3-phosphoglycerate dehydrogenase (Ndas_0174)
  • D-3-phosphoglycerate dehydrogenase (Mesil_2386)
  • D-3-phosphoglycerate dehydrogenase (Slip_0010)
  • D-3-phosphoglycerate dehydrogenase (Trad_0302)
  • D-3-phosphoglycerate dehydrogenase (Acear_0027)
  • D-3-phosphoglycerate dehydrogenase (Mahau_0665)
  • D-3-phosphoglycerate dehydrogenase (Mzhil_1019)
  • D-3-phosphoglycerate dehydrogenase (Mesop_1331)
  • D-3-phosphoglycerate dehydrogenase (Thein_0855)
  • 3-phosphoglycerate dehydrogenase (Phgdh)
  • phosphoglycerate dehydrogenase (PHGDH)
  • phosphoglycerate dehydrogenase (Phgdh)
  • 3-PGDH protein
  • 3PGDH protein
  • 4930479N23 protein
  • A10 protein
  • ECK2909 protein
  • embryo sac development arrest 9 protein
  • F10M10.7 protein
  • fb38f06 protein
  • JW2880 protein
  • PDG protein
  • PGAD protein
  • PGD protein
  • PGDH protein
  • SERA protein
  • wu:fb38f06 protein
  • zgc:65956 protein

Protein level used designations for PHGDH

D-3-phosphoglycerate dehydrogenase , 3-phosphoglycerate dehyrogenase , 3-phosphoglycerate dehydrogenase , 3-PGDH

GENE ID SPECIES
321928 Danio rerio
829568 Arabidopsis thaliana
945258 Escherichia coli str. K-12 substr. MG1655
8639711 Sphaerobacter thermophilus DSM 20745
8875608 Denitrovibrio acetiphilus DSM 12809
8878240 Meiothermus ruber DSM 1279
8983712 Methanohalophilus mahii DSM 5219
9170634 Arcobacter nitrofigilis DSM 7299
9244005 Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111
9251902 Meiothermus silvanus DSM 9946
9272777 Syntrophothermus lipocalidus DSM 12680
9279275 Truepera radiovictrix DSM 17093
9512008 Acetohalobium arabaticum DSM 5501
10607400 Mahella australiensis 50-1 BON
10822643 Methanosalsum zhilinae DSM 4017
10825145 Mesorhizobium opportunistum WSM2075
10841100 Thermodesulfatator indicus DSM 15286
236539 Mus musculus
26227 Homo sapiens
58835 Rattus norvegicus
100144529 Sus scrofa
505103 Bos taurus
739534 Pan troglodytes
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