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phospholipase A2, Group IIA (Platelets, Synovial Fluid) Proteins (PLA2G2A)

The protein encoded by PLA2G2A is a member of the phospholipase A2 family (PLA2). Additionally we are shipping PLA2G2A Antibodies (54) and PLA2G2A Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PLA2G2A 5320 P14555
PLA2G2A 29692 P14423
PLA2G2A 18780 P31482
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Top PLA2G2A Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Rat His tag phospholipase A2, Group IIA (Platelets, Synovial Fluid) (PLA2G2A) (AA 22-146), (full length) protein (His tag) 500 μg Log in to see 56 to 66 Days
$1,155.00
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,075.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,249.50
Details
Yeast Guinea Pig His tag   1 mg Log in to see 56 to 66 Days
$2,253.17
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   2 μg Log in to see 6 to 11 Days
$142.86
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details

PLA2G2A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Rat (Rattus)

Mouse (Murine)

Top referenced PLA2G2A Proteins

  1. Human PLA2G2A Protein expressed in Human Cells - ABIN2004058 : Fijneman, Cormier: The roles of sPLA2-IIA (Pla2g2a) in cancer of the small and large intestine. in Frontiers in bioscience : a journal and virtual library 2008 (PubMed)
    Show all 2 references for ABIN2004058

More Proteins for phospholipase A2, Group IIA (Platelets, Synovial Fluid) (PLA2G2A) Interaction Partners

Human phospholipase A2, Group IIA (Platelets, Synovial Fluid) (PLA2G2A) interaction partners

  1. Overexpression of sPLA2-IIA does not alter MCP-1 (show CCL2 Proteins) level at baseline, but could enhance the atherogenic effect of oxidized LDL in HASMCs, at least partly due to activation of Akt (show AKT1 Proteins).

  2. These results suggest that the genetic ablation of iPLA2b increased iron uptake in the brain through the activation of IRP2 (show IREB2 Proteins) and upregulation of DMT1 (show DMRT1 Proteins), which may be associated with mitochondrial dysfunction.

  3. IL-22 (show IL22 Proteins) induced at an early stage of L. monocytogenes infection enhances innate immunity against L. monocytogenes in the liver by stimulating hepatocytes to produce PLA2G2A

  4. PLA2G2A was detected in all samples of endometriomas, but not in normal endometrium, and immunohistochemistry showed PLA2G2A-specific staining in epithelial cells of endometrioma paraffin sections.

  5. Results indicate that secreted phospholipase A2 IIA (sPLA (show YWHAZ Proteins)2-IIA) as an enzyme working in concert with (show ALOX12 Proteins) platelet microparticles (MPs) 12-lipoxygenase (12-LO) to promote internalization.

  6. Secretory PLA2 IIa expression can predict the clinical outcome of lung adenocarcinoma patients.

  7. Co-expression of PLA2G2A and COX-2 significantly correlated with the depth of invasion (p=0.004)and with TNM (show ODZ1 Proteins) stage (p=0.04) of esophageal squamous cell carcinoma

  8. sPLA2 are secreted from ciliated cells and appear to induce mucin (show SLC13A2 Proteins) and cysLT secretion from goblet cells, strongly suggesting that airway goblet cells are proinflammatory effector cells.

  9. Studies indicate that the expression of secreted phospholipases A2 (sPLA2s), most notably the group IIA, III and X enzymes, is dysregulated in various malignant tissues.

  10. PLA2G2A levels increase in expectorations of cystic fibrosis patients in an age-dependent manner.

Mouse (Murine) phospholipase A2, Group IIA (Platelets, Synovial Fluid) (PLA2G2A) interaction partners

  1. Progesterone-induced Acrosome Exocytosis Requires Sequential Involvement of Calcium-independent Phospholipase A2beta (iPLA2beta (show PLA2G6 Proteins)) and Group X Secreted Phospholipase A2 (show YWHAZ Proteins) (sPLA2).

  2. Data show that the coordinated action of phospholipase A2 (show YWHAZ Proteins) IIA (sPLA2-IIA) and 12-lipoxygenase (12-LO (show ALOX15 Proteins)) promotes inflammatory arthritis.

  3. Pla2g2a sequence varies between tumor resistant and sensitive mouse strains. Some of these variations in the promoter region affect Pla2g2a expression and nonsense-mediated RNA decay also contributes to reducing Pla2g2a mRNA in tumor-sensitive strains.

  4. hydrolysis of the mitochondrial membrane by sPLA2-IIA yields inflammatory mediators (ie, lysophospholipids, fatty acids, and mtDNA) that promote leukocyte activation

  5. Ionomycin causes susceptibility to phospholipase A2 while temperature-induced increases in membrane fluidity fail: possible involvement of actin fragmentation.

  6. two of these isoforms, sPLA2 IIA and sPLA2 IIF (show PLA2G2F Proteins), localize to the upper stratum granulosum and increase in response to experimental barrier perturbation.

  7. Investigation into the role of phosphatidylserine in modifying the susceptibility of lymphocytes to secretory phospholipase A(2) using cells deficient in the expression of scramblase.

  8. Data show changes in cell morphology and upregulation of ERK1/2, iNOS and sPLA-IIA expression in astrocytes and microglia on exposure to lipopolysaccharides and cytokines.

  9. Treated mice exhibited upregulated sPLA2-IIa and cytokine gene transcription.

  10. sPLA(2) may play a role in the development of the histologic changes produced by gastroduodenal reflux in esophageal mucosa.

Guinea Pig phospholipase A2, Group IIA (Platelets, Synovial Fluid) (PLA2G2A) interaction partners

  1. PLA2G2A production is induced by Pseudomonas aeruginosa.

PLA2G2A Protein Profile

Protein Summary

The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.

Gene names and symbols associated with PLA2G2A

  • phospholipase A2, group IIA (platelets, synovial fluid) (PLA2G2A)
  • phospholipase A2, group IIA (platelets, synovial fluid) (Pla2g2a)
  • EF protein
  • Mom1 protein
  • Pla2 protein
  • PLA2B protein
  • PLA2L protein
  • PLA2S protein
  • PLAS1 protein
  • sPLA2 protein
  • sPla2-IIA protein

Protein level used designations for PLA2G2A

GIIC sPLA2 , NPS-PLA2 , group IIA phospholipase A2 , non-pancreatic secretory phospholipase A2 , phosphatidylcholine 2-acylhydrolase 2A , phospholipase A2, membrane associated , eted enzyme type IIA phospholipase A2 , platelet phospholipase A2 , enhancing factor , modifier of Min1 , non-pancreatic secreted type II phospholipase A2 , secretory group II phospholipase A2 , typeII phospholipase A2

GENE ID SPECIES
5320 Homo sapiens
29692 Rattus norvegicus
18780 Mus musculus
521383 Bos taurus
100135599 Cavia porcellus
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