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phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent) Proteins (PLA2G4A)

PLA2G4A encodes a member of the cytosolic phospholipase A2 group IV family. Additionally we are shipping phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent) Antibodies (107) and phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent) Kits (38) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PLA2G4A 18783 P47713
PLA2G4A 5321 P47712
PLA2G4A 24653  
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Top phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent) Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$798.60
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,202.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$920.54
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PLA2G4A Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,
Rat (Rattus)

More Proteins for phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent) (PLA2G4A) Interaction Partners

Mouse (Murine) phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent) (PLA2G4A) interaction partners

  1. The data emphasize the importance of the PLCeta2 EF-hand domain and articulation of PLCeta2 with LIMK-1 (show LIMK1 Proteins) in regulating neuritogenesis.

  2. show that accumulation of Abeta (show APP Proteins) induced elevation of APP (show APP Proteins) protein expression mediated by cPLA2 alpha, PGE2 release, and CREB (show CREB1 Proteins) activation via protein kinase A pathway

  3. Prostaglandins from cPLA2-alpha/COX1 pathway and mitogen-activated protein kinases regulate gene expression in Candida albicans-infected macrophages.

  4. Thymocyte maturation can occur independently of cPLA2-alpha.

  5. The study reports the formation of a multiprotein complex at the G2-to-M transition in vitro and in vivo. Group IVA cytosolic phospholipase A2 (cPLA2-alpha) acts as a bridge in this complex to promote binding of SIRT2 (show SIRT2 Proteins) to cyclin A (show CCNA2 Proteins)-Cdk2 (show CDK2 Proteins).

  6. osteoblastic cytosolic phospholipase A2 is crucially involved in ET-1 (show EDN1 Proteins)-induced prostaglandin formation.

  7. Data indicate that cytosolic phospholipase A2alpha (cPLA2alpha) mediates interleukin 6 (IL6 (show IL6 Proteins)) induction by Pseudomonas aeruginosa pulmonary infection.

  8. our data indicate that SR-A (show MSR1 Proteins) localizes in LRs and that LRs are required to couple SR-A (show MSR1 Proteins) to PLA2 (show PLA2G2A Proteins) activation during SRA (show MSR1 Proteins)-mediated macrophage attachment.

  9. cPLA2 participates in CRHR1 (show CRHR1 Proteins)-induced apoptosis and CRHR2 (show CRHR2 Proteins)-inhibited apoptosis.

  10. cPLA2 deletion ameliorates motor deficits and reduces cell loss and tissue damage after spinal cord injury.

Human phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent) (PLA2G4A) interaction partners

  1. genetic association study in Quebec City population: Data suggest total plasma n-6 fatty acid phospholipid levels and C-reactive protein (show CRP Proteins) are modulated by SNPs in PLA2G4A and PLA2G6 (show PLA2G6 Proteins) alone or in combination with fish oil dietary supplementation.

  2. cPLA2alpha plays an important role in cell cycle re-entry by quiescent prostate cancer cells

  3. Thymocyte maturation can occur independently of cPLA2-alpha.

  4. These studies constitute a definitive account, demonstrating the fundamental role of cPLA2alpha to eicosanoid formation and cellular responses within the human circulation.

  5. The study reports the formation of a multiprotein complex at the G2-to-M transition in vitro and in vivo. Group IVA cytosolic phospholipase A2 (cPLA2-alpha) acts as a bridge in this complex to promote binding of SIRT2 (show SIRT2 Proteins) to cyclin A (show CCNA2 Proteins)-Cdk2 (show CDK2 Proteins).

  6. EGF (show EGF Proteins) stimulates platelet-activating factor production in ovarian cancer cells in a manner that requires cPLA2.

  7. We conclude that cPLA2alpha is required for sustaining AKT (show AKT1 Proteins) phosphorylation at Ser473 and cell proliferation in colorectal cancer cells with PI3K (show PIK3CA Proteins) mutation

  8. alphaSN triggered synapse damage via hyperactivation of cPLA2

  9. Suggest retinal pigment epithelium metabolism of 7-ketocholesterol occurs by esterification to fatty acids via cPLA2alpha and SOAT1 (show SOAT1 Proteins) followed by selective efflux to HDL (show HSD11B1 Proteins).

  10. Data indicate 3-(1-Aryl-1H-indol-5-yl)propanoic acids a potent inhibitor of cytosolic phospholipase A2alpha (cPLA2alpha).

Cow (Bovine) phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent) (PLA2G4A) interaction partners

  1. result suggests that cPLAPgamma may act as a G protein, activating cPLA(2)alpha prior to reaching full intracellular Ca(2 (show CA2 Proteins) ) concentrations

  2. Ovulation is associated with an LH/hCG (show CGA Proteins)-dependent induction of PLA2G4A in GC via the adenylyl cyclase/cAMP pathway.

  3. Activation of cytosolic phospholipase A2 and fatty acid transacylase is essential but not sufficient for thrombin (show F2 Proteins)-induced smooth muscle cell proliferation.

Horse (Equine) phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent) (PLA2G4A) interaction partners

  1. The results indicate that PLA2 (show YWHAZ Proteins) activity in equine endometrium changes with the stage of the oestrous cycle and thus may be influenced by systemic hormone concentrations.

  2. During pregnancy, PLA2 (show YWHAZ Proteins) expression may be sufficient to initiate the cascade for prostaglandin f2alpha secretion and does not play a direct role in maternal recognition of pregnancy.

phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent) (PLA2G4A) Protein Profile

Protein Summary

This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.

Gene names and symbols associated with PLA2G4A

  • cytosolic phospholipase a2 (cpla2)
  • cytosolic phospholipase A2-like (LOC100520687)
  • phosphatidyl choline 2-acylhydrolase cPLA2 (LOC100008748)
  • phospholipase A2, group IVA (cytosolic, calcium-dependent) (Pla2g4a)
  • phospholipase A2, group IVA (cytosolic, calcium-dependent) (PLA2G4A)
  • phospholipase A2, group IVA (cytosolic, calcium-dependent) (pla2g4a)
  • cPLA2 protein
  • cPLA2-alpha protein
  • cPLA2alpha protein
  • PLA2 protein
  • Pla2c protein
  • PLA2G1B protein
  • Pla2g4 protein
  • PLA2G4A protein

Protein level used designations for PLA2G4A

cytosolic phospholipase A2 , phospholipase A2 group IVA , Phospholipase A2 group IVA , Cytosolic phospholipase A2 (CPLA2) , Type IV PLA2 , cPLA2-alpha , cytosolic PLA2 , phospholipase A2, group 4 , cPLA2 , calcium-dependent phospholipid-binding protein , lysophospholipase , phosphatidylcholine 2-acylhydrolase , phospholipase A2 cytosolic , phospholipase A2, group IB (pancreas)

GENE ID SPECIES
30554 Danio rerio
100520687 Sus scrofa
100008748 Oryctolagus cuniculus
18783 Mus musculus
5321 Homo sapiens
24653 Rattus norvegicus
525072 Bos taurus
396394 Gallus gallus
100033889 Equus caballus
480048 Canis lupus familiaris
101111472 Ovis aries
380561 Xenopus laevis
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