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phospholipase A2, Group VI (Cytosolic, Calcium-Independent) Proteins (PLA2G6)

The protein encoded by PLA2G6 is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. Additionally we are shipping PLA2G6 Antibodies (37) and PLA2G6 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PLA2G6 53357 P97819
PLA2G6 8398 O60733
Rat PLA2G6 PLA2G6 360426 P97570
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Top PLA2G6 Proteins at

Showing 5 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_HEK-293 Human His tag   0.05 mg Log in to see 2 to 3 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

PLA2G6 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,

More Proteins for phospholipase A2, Group VI (Cytosolic, Calcium-Independent) (PLA2G6) Interaction Partners

Mouse (Murine) phospholipase A2, Group VI (Cytosolic, Calcium-Independent) (PLA2G6) interaction partners

  1. iPLA2-gamma (show PNPLA8 Proteins) has a protective functional role in the normal glomerulus and in glomerulonephritis.

  2. Results suggest that the degeneration of dopaminergic neurons occurs mainly in the distal region of axons in iPLA2beta-KO mice.

  3. This study showed that the absence of iPLA2beta activity does not influence myocardial inflammation, but iPLA2beta is essential for T. cruzi clearance.

  4. Results support the deleterious role of iPLA2beta in severe obesity associated NAFLD.

  5. Genetic or molecular impairment of PLA2g6-dependent Ca(2+) signalling is a trigger for autophagic dysfunction, progressive loss of dopamine (show CA2 Proteins)rgic (DA) neurons in substantia nigra pars compacta and age-dependent L-DOPA-sensitive motor dysfunction.

  6. An inactivation of iPLA2beta exacerbated pathogenesis of experimental colitis by promoting intestinal epithelial cell apoptosis, inhibiting crypt cell regeneration, and causing damage to mucus barrier allowing an activation of innate immune response.

  7. diapocynin inhibited ROS (show ROS1 Proteins) production, abolished iPLA2 activity and reduced Ca2 (show CA2 Proteins)+ influx through stretch-activated and store-operated channels, two major pathways responsible for excessive Ca2 (show CA2 Proteins)+ entry in dystrophic muscle

  8. Mice deficient in iPLA2Beta show evidence of neuroinflammation and motor dysfunction in later life.

  9. membrane potential sensitive activity is the iPLA2gamma (show PNPLA8 Proteins)

  10. In this study we demonstrate for the first time that corticostriatal LTP (show SCP2 Proteins) is dependant on iPLA2 signalling, which can be reversed with application of DHA.

Human phospholipase A2, Group VI (Cytosolic, Calcium-Independent) (PLA2G6) interaction partners

  1. Finding suggest the broadness of the clinical spectrum of group VI phospholipases A2 (PLA2G6)-related neurodegeneration.

  2. A homozygous novel mutation at position c.2277-1G>C in PLA2G6 gene presumed to give rise to altered splicing, was detected, thus confirming the diagnosis of infantile Neuroaxonal Dystrophy (INAD).

  3. Three catalytically active cPLA2 (show PLA2G4A Proteins), iPLA2, and sPLA2 (show PLA2G2A Proteins) are expressed in different areas within the human spermatozoon cell body. Spermatozoa with a significant low motility showed strong differences both in terms of total specific activity and of different intracellular distribution, compared with normal spermatozoa. Phospholipases could be potential biomarkers of asthenozoospermia.

  4. This study demonstrated that elevated expression of alphaSyn/PalphaSyn in mitochondria appears to be the early response to PLA2G6-deficiency in neurons.

  5. Stimulation of adrenoreceptors causes increased iPLA2 expression via MAP kinase/ERK (show MAPK1 Proteins) 1 (show MAPK3 Proteins)/2.

  6. genetic association study in Quebec City population: Data suggest total plasma n-6 fatty acid phospholipid levels and C-reactive protein (show CRP Proteins) are modulated by SNPs in PLA2G4A (show PLA2G4A Proteins) and PLA2G6 alone or in combination with fish oil dietary supplementation.

  7. Mutations in PLA2G6 altered Golgi morphology, O-linked glycosylation and sialylation of protein in patients with neurodegeneration

  8. PLA2G6 mutations in Indian patients with infantile neuroaxonal dystrophy and atypical late-onset neuroaxonal dystrophy

  9. Results demonstrated no significant impact of PLA2G6 and PLA2G4C (show PLA2G4C Proteins) gene polymorphisms on attenuated niacin skin flushing in schizophrenia patients.

  10. Analysis of the cells from idiopathic Parkinson's disease patients reveals a significant deficiency in store-operated PLA2g6-dependent Ca(2 (show CA2 Proteins)+) signalling

PLA2G6 Protein Profile

Protein Summary

The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date.

Gene names and symbols associated with PLA2G6

  • phospholipase A2, group VI (cytosolic, calcium-independent) (pla2g6)
  • phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6)
  • phospholipase A2, group 6 (cytosolic, calcium-independent) (pla2g6)
  • phospholipase A2, group VI (Pla2g6)
  • phospholipase A2, group VI (cytosolic, calcium-independent) (Pla2g6)
  • BB112799 protein
  • CaI-PLA2 protein
  • GVI protein
  • INAD1 protein
  • iPLA(2)beta protein
  • iPla2 protein
  • IPLA2-VIA protein
  • iPLA2beta protein
  • MGC83523 protein
  • NBIA2 protein
  • NBIA2A protein
  • NBIA2B protein
  • PARK14 protein
  • PLA2 protein
  • PLA2G6 protein
  • PNPLA9 protein
  • wu:fc06g09 protein
  • zgc:77476 protein

Protein level used designations for PLA2G6

85 kDa calcium-independent phospholipase A2 , patatin-like phospholipase domain containing 9 , phospholipase A2, group 6 (cytosolic, calcium-independent) , phospholipase A2, group VI (cytosolic, calcium-independent) , 85 kDa calcium-independent phospholipase A2-like , 85/88 kDa calcium-independent phospholipase A2 , GVI PLA2 , caI-PLA2 , group VI phospholipase A2 , iPLA2-beta , intracellular membrane-associated calcium-independent phospholipase A2 beta , patatin-like phospholipase domain-containing protein 9 , calcium-independent phospholipase A2 , cytosolic, calcium-independent phospholipase A2 , neurodegeneration with brain iron accumulation 2

406370 Danio rerio
418028 Gallus gallus
446689 Xenopus laevis
481256 Canis lupus familiaris
700184 Macaca mulatta
100055064 Equus caballus
100415535 Callithrix jacchus
100445065 Pongo abelii
100515081 Sus scrofa
100549498 Meleagris gallopavo
100605211 Nomascus leucogenys
53357 Mus musculus
8398 Homo sapiens
535381 Bos taurus
101103799 Ovis aries
360426 Rattus norvegicus
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