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PLA2R1 represents a phospholipase A2 receptor. Additionally we are shipping PLA2R1 Kits (8) and PLA2R1 Proteins (7) and many more products for this protein.
Showing 10 out of 45 products:
Human Polyclonal PLA2R1 Primary Antibody for ICC, IF - ABIN4345962
Debiec, Ronco: PLA2R autoantibodies and PLA2R glomerular deposits in membranous nephropathy. in The New England journal of medicine 2011
Show all 8 references for ABIN4345962
Human Polyclonal PLA2R1 Primary Antibody for WB - ABIN4345961
Silliman, Moore, Zallen, Gonzalez, Johnson, Elzi, Meng, Hanasaki, Ishizaki, Arita, Ao, England, Banerjee: Presence of the M-type sPLA(2) receptor on neutrophils and its role in elastase release and adhesion. in American journal of physiology. Cell physiology 2002
Show all 2 references for ABIN4345961
Human Polyclonal PLA2R1 Primary Antibody for IHC, ELISA - ABIN347711
Hoxha, Harendza, Zahner, Panzer, Steinmetz, Fechner, Helmchen, Stahl: An immunofluorescence test for phospholipase-A2-receptor antibodies and its clinical usefulness in patients with membranous glomerulonephritis. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2011
Study showed that CTLD1-2 as well as the FNII domain of PLA2R were responsible for binding to collagen I and collagen-dependent migration in both mouse and human PLA2R.
PLA2R might play a pathogenic role in myocardial infarction of PLA2R-deficient mice, through impaired healing of the infarcted region.
PLA2R deficiency increased sPLA2 (show PLA2G2A Antibodies)-IB and -X levels in the lung through their impaired clearance from the lung, leading to exaggeration of lung inflammation induced by OVA treatment in a murine model.
Accordingly, PLA2R ABs assay seems to be promising tool not only to diagnose MN but also to predict the course of the disease and could open the way to personalize therapy. [review]
PLA2R1 expression in breast cancer cells is controlled by DNA methylation (show HELLS Antibodies) and histone modifications
Assessments of both serum PLA2R antibodies and PLA2R antigen in glomeruli were more sensitive for the diagnosis of PLA2R-related membranous nephropathy
Data indicate that enhanced granular expression of phospholipase A2 (show YWHAZ Antibodies) receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A (show THSD7A Antibodies)) was detected in 9.1% and 52.7%, respectively, of the patients with idiopathic membranous nephropathy (MN).
Anti-PLA2R antibodies were found in Japanese patients with idiopathic membranous nephropathy; however, the prevalence was lower than that of any other Asian country.
Suggest that PLA2R has a contributory role in the pathogenesis of paediatric idiopathic membranous nephropathy.
Renal biopsy PLA2R positivity was common in idiopathic membranous nephropathy (MN) and HBV-MN but rare in lupus-associated MN, and it was closely associated with serum PLA2R-Ab production.
Case Report: PLA2R positive membranous nephropathy in kidney transplant recipient with both IgA nephropathy and HCV infection long after kidney transplant from identical twin.
The detection and measurement of PLA2R-AB in idiopathic membranous nephropathy patients may be important tool in monitoring of the disease and efficacy of the treatment.
serological anti-PLA2R testing has diagnostic value for differentiating iMN from sMN (show STMN1 Antibodies), but it must be interpreted in context with patient clinical characteristics (degree of proteinuria, immunosuppressive treatment, time of detection).
This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.
phospholipase A2 receptor 1, 180kDa
, 180 kDa secretory phospholipase A2 receptor
, M-type receptor
, PLA2-I receptor
, phospholipase A2, group IB, pancreas, receptor
, secretory phospholipase A2 receptor
, C-type lectin domain family 13 member C