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anti-phosphoprotein Enriched in Astrocytes 15 (PEA15) Antibodies

PEA15 encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Additionally we are shipping PEA15 Proteins (12) and PEA15 Kits (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PEA15 8682 Q15121
PEA15 364052 Q5U318
PEA15 18611 Q62048
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Top anti-PEA15 Antibodies at antibodies-online.com

Showing 10 out of 105 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PEA15 Antibody Titration: 0.2-1 ug/mlPositive Control: 721_B cell lysate WB Suggested Anti-PEA15 Antibody  Positive Control: Lane 1:241 µg EGFP-transfected MCF7 lysate Lane 2: 041 µg EGFP-PEA15 transfected MCF7 lysate Primary Antibody Dilution: 1:0000Secondary Antibody: Goat anti-rabbit-HRP Secondry  Antibody Dilution: 1:0000Submitted by: Yann Wallez (Sanford-Burnham Medical Research Institute) 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of PEA-15 Antibody (C-term) (ABIN652463) in T47D cell line lysates (35 µg/lane).PEA-15 (arrow) was detected using the purified polyclonal antibody. Western blot analysis of PEA-15 Antibody (C-term) (ABIN652463) in mouse lung tissue lysates (35 µg/lane).PEA-15 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB (LEFT) Western blot analysis of PEA-15 Antibody (C-term) in T47D cell line lysates (35ug/lane).PEA-15 (arrow) was detected using the purified Pab. (RIGHT) Western blot analysis of PEA-15 Antibody (C-term) in mouse lung tissue lysates (35ug/lane).PEA-15 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from COS7 cells treated with TNF 20ng/ml 5', using PEA-15 (Phospho-Ser104) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human heart, using PEA-15 (Phospho-Ser104) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IF, ELISA Immunofluorescence analysis of MCF7 cells, using PEA15 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-PEA15 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Human brain WB Suggested Anti-PEA15  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: Human brain 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from COS7 cells treated with INSULIN 0.01U/ML 15', using PEA-15 (Phospho-Ser116) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human skeletal muscle, using PEA-15 (Phospho-Ser116) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IF, IHC (p), ELISA, WB Anti-PEA15 antibody IHC staining of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN959361 concentration 10 ug/ml. 50 μL Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from Jurkat cells, treated with PMA 125ng/ml 30', using PEA-15 (Ab-116) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using PEA-15 (Ab-116) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details

PEA15 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-PEA15 Antibodies

  1. Human Polyclonal PEA15 Primary Antibody for FACS, IHC (p) - ABIN652463 : Trencia, Perfetti, Cassese, Vigliotta, Miele, Oriente, Santopietro, Giacco, Condorelli, Formisano, Beguinot: Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action. in Molecular and cellular biology 2003 (PubMed)
    Show all 3 references for ABIN652463

  2. Human Polyclonal PEA15 Primary Antibody for EIA, WB - ABIN453779 : Sugiyama, Masuda, Shinoda, Nakamura, Tomita, Ishihama: Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications. in Molecular & cellular proteomics : MCP 2007 (PubMed)
    Show all 2 references for ABIN453779

  3. Cow (Bovine) Polyclonal PEA15 Primary Antibody for WB - ABIN2783293 : Eckert, Böck, Tagscherer, Haas, Grund, Sykora, Herold-Mende, Ehemann, Hollstein, Chneiweiss, Wiestler, Walczak, Roth: The PEA-15/PED protein protects glioblastoma cells from glucose deprivation-induced apoptosis via the ERK/MAP kinase pathway. in Oncogene 2008 (PubMed)

  4. Human Polyclonal PEA15 Primary Antibody for IF, ELISA - ABIN1534480 : Wolford, Bogardus, Ossowski, Prochazka: Molecular characterization of the human PEA15 gene on 1q21-q22 and association with type 2 diabetes mellitus in Pima Indians. in Gene 2000 (PubMed)

More Antibodies against PEA15 Interaction Partners

Human phosphoprotein Enriched in Astrocytes 15 (PEA15) interaction partners

  1. High PED expression is associated with esophageal carcinoma.

  2. The nuclear translocation of SApErk1/ 2 apart from PEA-15 as an important mechanism to reverse senescence phenotype.

  3. Latent HCMV infection of CD34 (show CD34 Antibodies) + cells protects cells from FAS (show FAS Antibodies)-mediated apoptosis through the cellular IL-10 (show IL10 Antibodies)/PEA-15 pathway.

  4. New therapeutic targets based around PEA-15 and its associated interactions are now being uncovered and could provide novel avenues for treatment strategies in multiple diseases.

  5. PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism

  6. Omi/HtrA2 (show HTRA2 Antibodies) overexpression promotes hepatocellular carcinoma cell apoptosis and the ped/pea-15 expression level causes this difference of the Omi/HtrA2 (show HTRA2 Antibodies) pro-apoptotic marker in the various hepatocellular carcinoma cell lines

  7. Results suggest that neurochemical adaptations of brain FADD (show FADD Antibodies), as well as its interaction with PEA-15, could play a major role to counteract the known activation of the mitochondrial apoptotic pathway in major depression

  8. Data show that phosphoprotein enriched in astrocytes of 15 kDa (PEA-15) influences dephosphorylation of epidermal growth factor receptor (EGFR (show EGFR Antibodies)) via extracellular signal-regulated kinases ERK1/2 (show MAPK1/3 Antibodies) sequestration in the cytoplasm.

  9. Tumor suppressor PEA15 is a regulator of genome integrity and is an integral component of the DNA damage response pathway.

  10. Up-regulated chaperone-mediated autophagy activity characteristic of most types of cancer cell enhances oncogenesis by shifting the balance of PED function toward tumor promotion.

Mouse (Murine) phosphoprotein Enriched in Astrocytes 15 (PEA15) interaction partners

  1. Data suggest that PEA-15 contributes to the specification of the cytokine pattern of activated Th cells, thus highlighting a potential new target to interfere with T cell functional polarization and subsequent immune response.

  2. PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism

  3. Activated astrocytes are known to clear the Abeta (show APP Antibodies) deposited in the extracellular milieu, which is why they play a key role in regulating the progression of Alzheimer's disease (AD).

  4. Activation of peroxisome proliferator-activated receptor-gamma (PPARgamma (show PPARG Antibodies)) represses transcription of the ped/pea-15 gene.

  5. The findings revealed a novel mechanism by which PEA-15 positively regulates Ras/ERK signaling and increases the proliferation of H-Ras-transformed epithelial cells through enhanced phospholipase D1 expression and activation.

  6. PEA-15 did not differentiate and showed markedly enhanced autophagy. In these same cells, the autophagy inhibitor 3 (show PPP1R11 Antibodies)-methyladenine rescued TGF-beta1 (show TGFB1 Antibodies) effect on both autophagy and myogenesis, indicating that PEA-15 mediates TGF-beta1 (show TGFB1 Antibodies) effects in muscle.

  7. Data suggest that PED/PEA-15 may affect fibroblast motility by a mechanism, at least in part, mediated by ERK1/2 (show MAPK1/3 Antibodies).

  8. we propose that PEA-15 represents a novel point of convergence of the protein kinas C and MAPK/ERK (show MAPK1 Antibodies) pathways under gonadotropin releasing hormone stimulation

  9. PEA-15 regulates T-cell proliferation

  10. PEA-15 inhibits tumorigenesis in an MDA-MB-468 triple-negative breast cancer xenograft model through increased cytoplasmic localization of activated extracellular signal-regulated kinase.

PEA15 Antigen Profile

Protein Summary

This gene encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Studies using knockout mice suggest that this protein may protect astrocytes from TNF-induced apoptosis. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake.

Gene names and symbols associated with PEA15

  • phosphoprotein enriched in astrocytes 15 (PEA15) antibody
  • phosphoprotein enriched in astrocytes 15 (pea15) antibody
  • Astrocytic phosphoprotein PEA-15 (pea15) antibody
  • phosphoprotein enriched in astrocytes 15 (Pea15) antibody
  • phosphoprotein enriched in astrocytes 15A (Pea15a) antibody
  • DKFZp459O1410 antibody
  • HMAT1 antibody
  • HUMMAT1H antibody
  • Mat1 antibody
  • MAT1H antibody
  • PEA-15 antibody
  • Pea15 antibody
  • Pea15a antibody
  • PED antibody
  • Pkcs15 antibody

Protein level used designations for PEA15

phosphoprotein enriched in astrocytes 15 , Astrocytic phosphoprotein PEA-15 , 15 kDa phosphoprotein enriched in astrocytes , Phosphoprotein enriched in astrocytes, 15kD , astrocytic phosphoprotein PEA-15 , homolog of mouse MAT-1 oncogene , phosphoprotein enriched in diabetes , phosphoprotein enriched in astrocytes 15A , mammary transforming gene 1

GENE ID SPECIES
677706 Macaca mulatta
705026 Macaca mulatta
100145359 Xenopus (Silurana) tropicalis
100152480 Sus scrofa
100174153 Pongo abelii
100286636 Salmo salar
8682 Homo sapiens
364052 Rattus norvegicus
734852 Xenopus laevis
510586 Bos taurus
610113 Canis lupus familiaris
18611 Mus musculus
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