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PEA15 encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Additionally we are shipping PEA15 Proteins (11) and PEA15 Kits (7) and many more products for this protein.
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Human Polyclonal PEA15 Primary Antibody for FACS, IHC (p) - ABIN652463
Trencia, Perfetti, Cassese, Vigliotta, Miele, Oriente, Santopietro, Giacco, Condorelli, Formisano, Beguinot: Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action. in Molecular and cellular biology 2003
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PP4 (show ANXA5 Antibodies) regulates breast cancer cell survival and identifies a novel PP4c (show PPP4C Antibodies)-PEA15 signalling axis in the control of breast cancer cell survival.
PEA15 expression was not significantly correlated with ovarian cancer antineoplastic drug resistance.
Data suggest the role of the phospholipase C epsilon (show PLCL1 Antibodies)-Protein kinase D (show PRKD1 Antibodies)-PEA15 protein-ribosomal S6 kinase (show RPS6KB1 Antibodies)-IkappaB-NF-kappa B (show NFKB1 Antibodies) pathway in facilitating inflammation and inflammation-associated carcinogenesis in the colon.
Integrin alpha5beta1 and p53 (show TP53 Antibodies) convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin (show BIRC5 Antibodies) in high-grade glioma.
High PED expression is associated with esophageal carcinoma.
The nuclear translocation of SApErk1/ 2 apart from PEA-15 as an important mechanism to reverse senescence phenotype.
Latent HCMV infection of CD34 (show CD34 Antibodies) + cells protects cells from FAS (show FAS Antibodies)-mediated apoptosis through the cellular IL-10 (show IL10 Antibodies)/PEA-15 pathway.
New therapeutic targets based around PEA-15 and its associated interactions are now being uncovered and could provide novel avenues for treatment strategies in multiple diseases.
PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism
Omi/HtrA2 (show HTRA2 Antibodies) overexpression promotes hepatocellular carcinoma cell apoptosis and the ped/pea-15 expression level causes this difference of the Omi/HtrA2 (show HTRA2 Antibodies) pro-apoptotic marker in the various hepatocellular carcinoma cell lines
Data suggest that PEA-15 contributes to the specification of the cytokine pattern of activated Th cells, thus highlighting a potential new target to interfere with T cell functional polarization and subsequent immune response.
Activated astrocytes are known to clear the Abeta (show APP Antibodies) deposited in the extracellular milieu, which is why they play a key role in regulating the progression of Alzheimer's disease (AD).
Activation of peroxisome proliferator-activated receptor-gamma (PPARgamma (show PPARG Antibodies)) represses transcription of the ped/pea-15 gene.
The findings revealed a novel mechanism by which PEA-15 positively regulates Ras/ERK signaling and increases the proliferation of H-Ras-transformed epithelial cells through enhanced phospholipase D1 expression and activation.
PEA-15 did not differentiate and showed markedly enhanced autophagy. In these same cells, the autophagy inhibitor 3 (show PPP1R11 Antibodies)-methyladenine rescued TGF-beta1 (show TGFB1 Antibodies) effect on both autophagy and myogenesis, indicating that PEA-15 mediates TGF-beta1 (show TGFB1 Antibodies) effects in muscle.
Data suggest that PED/PEA-15 may affect fibroblast motility by a mechanism, at least in part, mediated by ERK1/2 (show MAPK1/3 Antibodies).
we propose that PEA-15 represents a novel point of convergence of the protein kinas C and MAPK/ERK (show MAPK1 Antibodies) pathways under gonadotropin releasing hormone stimulation
PEA-15 regulates T-cell proliferation
PEA-15 inhibits tumorigenesis in an MDA-MB-468 triple-negative breast cancer xenograft model through increased cytoplasmic localization of activated extracellular signal-regulated kinase.
This gene encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Studies using knockout mice suggest that this protein may protect astrocytes from TNF-induced apoptosis. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake.
15 kDa phosphoprotein enriched in astrocytes
, Phosphoprotein enriched in astrocytes, 15kD
, astrocytic phosphoprotein PEA-15
, homolog of mouse MAT-1 oncogene
, phosphoprotein enriched in diabetes
, mammary transforming gene 1
, phosphoprotein enriched in astrocytes 15
, phosphoprotein enriched in astrocytes 15A
, Astrocytic phosphoprotein PEA-15