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phosphorylase, Glycogen, Liver Proteins (PYGL)

PYGL encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. Additionally we are shipping PYGL Antibodies (77) and PYGL Kits (42) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PYGL 110095 Q9ET01
PYGL 5836 P06737
PYGL 64035 P09811
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Top PYGL Proteins at antibodies-online.com

Showing 9 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 11 to 13 Days
$1,056.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PYGL Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
,
Rat (Rattus)

More Proteins for phosphorylase, Glycogen, Liver (PYGL) Interaction Partners

Mouse (Murine) phosphorylase, Glycogen, Liver (PYGL) interaction partners

  1. The in vivo consequences of disrupting the G(L)-phosphorylase a interaction, using a mouse model containing a Tyr284Phe substitution in the phosphorylase a-binding region of the hepatic glycogen (show GYS1 Proteins)-associated protein phosphatase-1 (show PPP1CB Proteins) protein, is reported.

Human phosphorylase, Glycogen, Liver (PYGL) interaction partners

  1. Susceptibility to excessive liver glycogen (show GYS1 Proteins) storage in patients with type 1 diabetes.

  2. Deficiency of liver glycogen phosphorylase is predominantly the result of missense mutations affecting enzyme activity. There are no common mutations and the severity of clinical symptoms varies significantly.

Pig (Porcine) phosphorylase, Glycogen, Liver (PYGL) interaction partners

  1. 4-alpha-glucanotransferase action of porcine liver GDE (show AGL Proteins) on four 6(4)-O-alpha-maltooligosyl-pyridylamino(PA)-maltooctaoses, in the presence or absence of an acceptor, maltohexaose, was examined.

PYGL Protein Profile

Protein Summary

This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with PYGL

  • phosphorylase, glycogen, liver (PYGL)
  • phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI) (pygl)
  • phosphorylase, glycogen, liver (pygl)
  • liver glycogen phosphorylase (Pygl)
  • phosphorylase, glycogen, liver (Pygl)
  • GSD6 protein
  • zgc:66314 protein

Protein level used designations for PYGL

glycogen phosphorylase, liver form , liver glycogen phosphorylase , phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI) , glycogen storage disease type VI-related protein , phosphorylase, glycogen; liver

GENE ID SPECIES
100066726 Equus caballus
378909 Gallus gallus
493916 Danio rerio
494832 Xenopus laevis
706853 Macaca mulatta
742309 Pan troglodytes
110095 Mus musculus
5836 Homo sapiens
403738 Canis lupus familiaris
100141306 Sus scrofa
505472 Bos taurus
64035 Rattus norvegicus
554320 Ovis aries
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