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SMG1 encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. Additionally we are shipping and and many more products for this protein.
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Human Monoclonal SMG1 Primary Antibody for IHC (p), ELISA - ABIN524936
Stalder, Mühlemann: Processing bodies are not required for mammalian nonsense-mediated mRNA decay. in RNA (New York, N.Y.) 2009
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smg-1 encodes a protein kinase (show CDK7 Antibodies) of the phosphatidylinositol kinase superfamily of protein kinases; SMG-1 kinase activity is required in vivo for nonsense-mediated mRNA decay and in vitro for SMG-2 (show UPF1 Antibodies) phosphorylation
A novel role is reported for smg-1 in lifespan and oxidative stress resistance in Caenorhabditis elegans.
The CK2 (show CSNK2A1 Antibodies) phospho-dependent interaction between TEL2 (show TELO2 Antibodies) and the R2TP complex affects phosphatidylinositol 3-kinase-related kinase functions and is essential for mTOR (show FRAP1 Antibodies) and SMG1 stability in vivo.
Results demonstrate a critical role for Smg1 in early mouse development and link the loss of this NMD factor to major and widespread changes in the mammalian transcriptome.
Knock down of the expression of SMG-1 inhibited tumor cell proliferation and induced the chemosensitivity of pancreatic cancer cells in vitro.
SMG1 was hypermethylated in 66% of AML (show RUNX1 Antibodies) samples compared with none in controls. mTOR (show FRAP1 Antibodies) expression level was negatively correlated to SMG1 expression in AML (show RUNX1 Antibodies) patients which indicated that SMG1 and mTOR (show FRAP1 Antibodies) maybe act antagonistically to regulate AML (show RUNX1 Antibodies) cell growth.
A genome-wide RNA interference screen Hepatocellular carcinoma cell lines revealed the role of suppressor of SMG-1 as determinant of sorafenib resistance.
SMG1 regulates NMD by recruiting UPF1 (show UPF1 Antibodies) and UPF2 (show UPF2 Antibodies) to distinct nearby positions, and can form a complex with UPF2 (show UPF2 Antibodies) in vivo in an UPF1 (show UPF1 Antibodies)-independent manner.
We conclude that SMG-1 is downregulated in HCC (show FAM126A Antibodies) and may represent a promising biomarker for predicting the prognosis of HCC (show FAM126A Antibodies), including the prognosis of early-stage patients.
Novel role for SMG-1 is identified in regulating Cdc25A (show CDC25A Antibodies) and suppressing oncogenic CDK2 (show CDK2 Antibodies) driven proliferation, confirming SMG-1 as a tumor suppressor.
This study demonstrated the quantitative regulation of Upf1 (show UPF1 Antibodies) and Upf2 (show UPF2 Antibodies) proteins by ubiquitin-proteasome system and SMG1.
SMG1 protein levels were significantly reduced in brain.
Downregulation of SMG1 causes the reduction in the level of Upf1 (show UPF1 Antibodies) phosphorylation and delays adipogenesis, suggesting the functional involvement of SMG1 in adipogenesis via SMD.
Data indicate that down-regulation of SMG1 expression is mediated by miRNA-125 binding to a microRNA response element in the 3' untranslated region of SMG1 mRNA, which leads to degradation of the SMG1 mRNA.
This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined.
serine/threonine-protein kinase SMG1
, PI-3-kinase-related kinase SMG-1
, SMG1 homolog, phosphatidylinositol 3-kinase-related kinase
, smg-1 homolog, phosphatidylinositol 3-kinase-related kinase
, phosphatidylinositol 3-kinase-related protein kinase
, lambda-interacting protein
, lambda/iota protein kinase C-interacting protein