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PSRC1 encodes a proline-rich protein. Additionally we are shipping proline/serine-Rich Coiled-Coil 1 Antibodies (78) and proline/serine-Rich Coiled-Coil 1 Proteins (5) and many more products for this protein.
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no association was found between the SNPs of rs599839, rs464218 and rs6698843 at the CELSR2 (show CELSR2 ELISA Kits)-PSRC1-SORT1 (show SORT1 ELISA Kits) and the risk of coronary artery disease or ischemic stroke
Thus, ANKRD53 is recruited to the mitotic spindle by DDA3 and acts as a regulator of spindle dynamics and cytokinesis.
Thus, our findings identified a definite regulatory mechanism of the search and capture process for stable spindle attachment through cross-talk between spindle dynamics and KT composition mediated by DDA3 and Ska1 (show SKA1 ELISA Kits).
DDA3 controls astral spindle formation and spindle positioning by targeting Cep290 (show CEP290 ELISA Kits) to the centrosome. Depletion of Cep290 (show CEP290 ELISA Kits) caused a reduction of the astral spindle, leading to misorientation of the mitotic spindle.
PSRC1 in the cholesterol gene cluster shows a significant association with coronary artery disease and its single nucleotide polymorphism regulates plasma cholesterol levels.
Thus, the EB1 (show MAPRE2 ELISA Kits)-based function of DDA3 links MT dynamics to directional cell migration
kinases control the function of DDA3 in the cell cycle by regulating its microtubules-polymerizing/bundling activities through sequential phosphorylation.
MCAK (show KIF2C ELISA Kits) and CENP-E (show CENPE ELISA Kits) are involved in DDA3-mediated chromosome congression.
the mitotic function of DDA3 is regulated by phosphorylation on the Ser225 residue.
The C-terminal domain confers its ability to associate with the mitotic spindle, while the regulatory N-terminal domain controls the microtubule-binding by the C-terminal domain and determines the cellular activity of the DDA3 protein.
A p53 (show TP53 ELISA Kits) response element mediates transcriptional activation
DDA3 is a novel microtubule-associated protein (show SPAG5 ELISA Kits) that binds to EB3 (show MAPRE3 ELISA Kits), and results implicate DDA3 and EB3 (show MAPRE3 ELISA Kits) in the beta-catenin (show CTNNB1 ELISA Kits)-mediated growth signaling.
This gene encodes a proline-rich protein. Studies of this gene and the related mouse gene suggest that this gene is regulated by p53 and may participate in p53-mediated growth suppression. The encoded protein may function as a microtubule destabilizing protein that controls spindle dynamics and mitotic progression by recruiting and regulating microtubule depolymerases. At least one genetic variation in this gene has been associated with decreased serum levels of low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding different isoforms have been described.
differential display and activated by p53
, p53-regulated DDA3
, proline/serine-rich coiled-coil protein 1