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PSRC1 encodes a proline-rich protein. Additionally we are shipping proline/serine-Rich Coiled-Coil 1 Antibodies (39) and proline/serine-Rich Coiled-Coil 1 Kits (8) and many more products for this protein.
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Human PSRC1 Protein expressed in Wheat germ - ABIN1316679
Mangé, Lacombe, Bascoul-Mollevi, Jarlier, Lamy, Rouanet, Maudelonde, Solassol: Serum autoantibody signature of ductal carcinoma in situ progression to invasive breast cancer. in Clinical cancer research : an official journal of the American Association for Cancer Research 2012
Thus, ANKRD53 is recruited to the mitotic spindle by DDA3 and acts as a regulator of spindle dynamics and cytokinesis.
Thus, our findings identified a definite regulatory mechanism of the search and capture process for stable spindle attachment through cross-talk between spindle dynamics and KT composition mediated by DDA3 and Ska1 (show SKA1 Proteins).
DDA3 controls astral spindle formation and spindle positioning by targeting Cep290 to the centrosome. Depletion of Cep290 caused a reduction of the astral spindle, leading to misorientation of the mitotic spindle.
PSRC1 in the cholesterol gene cluster shows a significant association with coronary artery disease and its single nucleotide polymorphism regulates plasma cholesterol levels.
Thus, the EB1 (show MAPRE2 Proteins)-based function of DDA3 links MT dynamics to directional cell migration
kinases control the function of DDA3 in the cell cycle by regulating its microtubules-polymerizing/bundling activities through sequential phosphorylation.
MCAK (show KIF2C Proteins) and CENP-E (show CENPE Proteins) are involved in DDA3-mediated chromosome congression.
the mitotic function of DDA3 is regulated by phosphorylation on the Ser225 residue.
The C-terminal domain confers its ability to associate with the mitotic spindle, while the regulatory N-terminal domain controls the microtubule-binding by the C-terminal domain and determines the cellular activity of the DDA3 protein.
Together our results show that hDDA3 is a p53 (show TP53 Proteins)- and DNA-damage down-regulated target that exhibits oncogenic characteristics.
A p53 (show TP53 Proteins) response element mediates transcriptional activation
DDA3 is a novel microtubule-associated protein (show SPAG5 Proteins) that binds to EB3 (show MAPRE3 Proteins), and results implicate DDA3 and EB3 (show MAPRE3 Proteins) in the beta-catenin (show CTNNB1 Proteins)-mediated growth signaling.
This gene encodes a proline-rich protein. Studies of this gene and the related mouse gene suggest that this gene is regulated by p53 and may participate in p53-mediated growth suppression. The encoded protein may function as a microtubule destabilizing protein that controls spindle dynamics and mitotic progression by recruiting and regulating microtubule depolymerases. At least one genetic variation in this gene has been associated with decreased serum levels of low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding different isoforms have been described.
differential display and activated by p53
, p53-regulated DDA3
, proline/serine-rich coiled-coil protein 1