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RND3 encodes a protein which is a member of the small GTPase protein superfamily. Additionally we are shipping RND3 Antibodies (35) and RND3 Proteins (13) and many more products for this protein.
Our data supported that RhoE could inhibit cell proliferation and promote apoptosis. Moreover, these tumor-suppressing effects might be acted through the negative regulation of EGFR (show EGFR ELISA Kits)/ERK (show EPHB2 ELISA Kits) signaling.
constant degradation of RND3 by chaperone-mediated autophagy is required to sustain rapid proliferation of gastric cancer cells.
RhoA-ROCK-Rnd3 feedback loop determined the local reassembly sites of the actin cortex during membrane blebbing.
We conclude that downregulation of RND3 is responsible for the enhancement of Notch (show NOTCH1 ELISA Kits) activity that promotes glioblastoma genesis.
the development and application of a novel data integration methodology reveals novel functions of RND3 in controlling glioma cell migration, invasion, proliferation, angiogenesis and clinical outcome.
Rnd3 regulates lung cancer cell proliferation through notch (show NOTCH1 ELISA Kits) signaling.
CXCR4 (show CXCR4 ELISA Kits) might be a downstream effector for RhoE
Transfection of pre-miR (show MLXIP ELISA Kits)-200c reduces RhoE expression.
RhoE may participate in human cancer progression and act as a candidate target of p53 (show TP53 ELISA Kits), and these findings also strongly suggest that RhoE may be a new candidate tumor suppressor and could serve as a potential target in the gene therapy of cancer.
define RhoE as a Notch1 (show NOTCH1 ELISA Kits) target that is essential for recruitment of N1IC to promoters of Notch1 (show NOTCH1 ELISA Kits) target genes, establishing a regulatory feedback loop in Notch1 (show NOTCH1 ELISA Kits) signaling
Rnd3 acted as a novel proangiogenic factor involved in cardiac responsive angiogenesis through HIF1alpha (show HIF1A ELISA Kits)-VEGFA (show VEGFA ELISA Kits) signaling promotion.
These results indicate that RhoE plays a role in suppressing tumor initiation and progression.
Rnd3 is a novel factor involved in intracellular calcium homeostasis regulation in the heart.
Animals with Rnd3 haploinsufficiency are predisposed to hemodynamic stress. Hyperactivation of Rho kinase (show ROCK2 ELISA Kits) activity is responsible in part for the apoptotic cardiomyopathy development.
Data show that the Plexin B2 (show PLXNB2 ELISA Kits) receptor interacts physically and functionally with Rnd3 and stimulates RhoA (show RHOA ELISA Kits) activity in migrating cortical neurons.
RhoE is indispensable for osteoclast migration and bone resorption by maintaining fast actin turnover in podosomes. RhoE activates podosome component cofilin (show CFL1 ELISA Kits) by inhibiting its Rock-mediated phosphorylation.
although Rnd3 expression is controlled transcriptionally by Ascl1 (show ASCL1 ELISA Kits), this proneural factor is itself required in radial glial progenitors only for proper orientation of cell divisions
Rnd3 is a regulator of Notch1 (show NOTCH1 ELISA Kits) signaling
These findings support our previous report revealing the important role of RhoE in the normal development of the nervous system
the important role of Rnd3/RhoE in the normal development
This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Rho family GTPase 3
, protein MemB
, ras homolog gene family, member E
, rho-related GTP-binding protein Rho8
, rho-related GTP-binding protein RhoE
, small GTP binding protein Rho8
, Rho related protein Rnd3/Rho8