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Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. Additionally we are shipping GRAF Antibodies (83) and GRAF Kits (7) and many more products for this protein.
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Human GRAF Protein expressed in Wheat germ - ABIN1345506
Jarius, Scharf, Begemann, Stöcker, Probst, Serysheva, Nagel, Graus, Psimaras, Wildemann, Komorowski: Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia. in Journal of neuroinflammation 2015
Show all 2 references for ABIN1345506
GRAF expression is a favorable prognostic marker in patients with acute myeloid leukemia (show BCL11A Proteins).
ADAR1 (show ADAR Proteins) regulates the expression of ARHGAP26 through A-to-I RNA editing by disrupting the binding of miR (show MLXIP Proteins)-30b-3p and miR (show MLXIP Proteins)-573 within the 3' UTR of ARHGAP26.
proposed that GRAF1 remodels membrane microdomains at adhesion sites into endocytic carriers, facilitating membrane turnover during cell morphological changes
Findings suggest that the hypermethylation of GRAF promoter might be one of early events in the development of AML (show RUNX1 Proteins).
a GTPase-activating protein (show RASA1 Proteins) that regulates muscle maturation and to highlight the functional importance of BAR domains in myotube formation
Decreased level of GRAF transcript is associated with acute myeloid leukemia (show BCL11A Proteins), myelodysplastic syndrome and chronic myeloid leukemia (show BCL11A Proteins).
The GRAF gene was down-regulated in AML (show RUNX1 Proteins), which might play a role in the leukemogenesis.
The analysis of the expression pattern of the GRAF1/OPHN-1 (show OPHN1 Proteins)-L gene in human tissues and organs revealed the predominant brain expression of a novel splicing isoform.
abnormal GRAF methylation might be an adverse prognostic event in MDS (show PAFAH1B1 Proteins)
Graf residues important for the structural integrity are critical for binding RhoA (show RHOA Proteins) and for the catalytic activity of GAP, but GTPase (show RACGAP1 Proteins) selectivity appears to be modulated by a more subtle interplay involving residues on the periphery of the main interface.
Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene.
Rho GTPase activating protein 26
, rho GTPase-activating protein 26-like
, GTPase regulator associated with focal adhesion kinase pp125(FAK)
, oligophrenin-1-like protein
, rho GTPase-activating protein 26
, rho-type GTPase-activating protein 26
, GTPase regulator associated with focal adhesion kinase
, rhoGap protein