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GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Additionally we are shipping rho GTPase Activating Protein 44 Antibodies (26) and many more products for this protein.
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Besides the already known chromosome 6 associations, the analysis of low-frequency single nucleotide polymorphisms brought up a new association in the RICH2 gene for progression to AIDS.
Knocking down expression of RICH 2 causes loss of the apical actin network and apical microvilli, an increase in actin bundles at the basal surface, and a reduction in cell height. (RICH 2 protein)
Demonstrates that the (show ARHGAP1 Proteins) RhoGAP domains of RICH-1 and RICH-2 can catalyze GT (show AK3 Proteins)P hydrolysis of both Rac1 and Cdc4 (show CDC42 Proteins)2, but not of Rho (show RHOA Proteins)A.
These results suggested that Rich2 controls dendritic spine morphogenesis and function via inhibition of Rac1.
Knock-down of Rich2 or disruption of Rich2-Shank3 complex, inhibits dendritic spine enlargement.
Shows that the RhoGAP (show ARHGAP1 Proteins) domain of the human RICH2 ortholog can catalyze GTP (show AK3 Proteins) hydrolysis of both Rac1 and Cdc42 (show CDC42 Proteins), but not of RhoA (show RHOA Proteins).
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Acts as a GTPase activitor in vitro for CDC42 and RAC1.
Rho-type GTPase-activating protein RICH2
, Rho GTPase activating protein 44
, RhoGAP interacting with CIP4 homologs protein 2
, rho GTPase-activating protein 44
, rho GTPase-activating protein RICH2
, Rho GTPase-activating protein RICH2