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ARHGAP8 encodes a member of the RHOGAP family. Additionally we are shipping and many more products for this protein.
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Pin1 (show PIN1 Proteins) regulates BPGAP1 function in Rho and Erk (show EPHB2 Proteins) signalling, with active Mek2 (show MAP2K2 Proteins) serving as a novel regulatory scaffold that promotes crosstalk between RhoGAP (show ARHGAP1 Proteins), Pin1 (show PIN1 Proteins) and Erk (show EPHB2 Proteins) in the regulation of cell migration.
BPGAP1 has a role in regulating cell dynamics with BNIP-2 (show BNIP2 Proteins) and Cdc42GAP (show ARHGAP1 Proteins) homology/Sec14p-like, proline-rich, and GTPase-activating protein (show RASA1 Proteins) domains of BPGAP1
RhoGAP (show ARHGAP1 Proteins) functionally interacts with cortactin (show CTTN Proteins) and represents a novel determinant in the regulation of cell dynamics.
ARHGAP8 expression was up-regulated in the majority of primary colorectal tumors analyzed in this work.
BPGAP1 is a novel RhoGAP (show ARHGAP1 Proteins) that co-ordinately regulates pseudopodia and cell migration through the interplay of its BNIP-2 (show BNIP2 Proteins) and Cdc42GAP (show ARHGAP1 Proteins) homology domains.
findings reveal a concomitant activation of endocytosis and ERK (show EPHB2 Proteins) signaling by BPGAP1 via the coupling of its proline-rich region, which targets EEN (show SH3GL1 Proteins) and its functional GAP domain
This paper compares the protein sequences and genomic structures of human and mouse ARHGAP8.
This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.
rho GTPase-activating protein 8
, Rho GTPase activating protein 8
, BCH domain-containing Cdc42GAP-like protein
, BNIP-2 and Cdc42GAP homology domain-containing, proline-rich and Cdc42GAP-like protein subtype-1
, rho-type GTPase-activating protein 8