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ARHGAP8 encodes a member of the RHOGAP family. Additionally we are shipping rho GTPase Activating Protein 8 Antibodies (3) and many more products for this protein.
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BPGAP1 provides a crucial spatiotemporal checkpoint where JNK (show MAPK8 Proteins) and MP1 (show PITRM1 Proteins)/MEK1 (show MAP2K1 Proteins) work in concert to regulate endosomal and nuclear ERK (show EPHB2 Proteins) signaling in cell proliferation control.
Pin1 (show PIN1 Proteins) regulates BPGAP1 function in Rho and Erk (show EPHB2 Proteins) signalling, with active Mek2 (show MAP2K2 Proteins) serving as a novel regulatory scaffold that promotes crosstalk between RhoGAP (show ARHGAP1 Proteins), Pin1 (show PIN1 Proteins) and Erk (show EPHB2 Proteins) in the regulation of cell migration.
BPGAP1 has a role in regulating cell dynamics with BNIP-2 (show BNIP2 Proteins) and Cdc42GAP (show ARHGAP1 Proteins) homology/Sec14p-like, proline-rich, and GTPase-activating protein (show RASA1 Proteins) domains of BPGAP1
RhoGAP (show ARHGAP1 Proteins) functionally interacts with cortactin (show CTTN Proteins) and represents a novel determinant in the regulation of cell dynamics.
ARHGAP8 expression was up-regulated in the majority of primary colorectal tumors analyzed in this work.
BPGAP1 is a novel RhoGAP (show ARHGAP1 Proteins) that co-ordinately regulates pseudopodia and cell migration through the interplay of its BNIP-2 (show BNIP2 Proteins) and Cdc42GAP (show ARHGAP1 Proteins) homology domains.
findings reveal a concomitant activation of endocytosis and ERK (show EPHB2 Proteins) signaling by BPGAP1 via the coupling of its proline-rich region, which targets EEN (show SH3GL1 Proteins) and its functional GAP domain
This paper compares the protein sequences and genomic structures of human and mouse ARHGAP8.
This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.
rho GTPase-activating protein 8
, Rho GTPase activating protein 8
, BCH domain-containing Cdc42GAP-like protein
, BNIP-2 and Cdc42GAP homology domain-containing, proline-rich and Cdc42GAP-like protein subtype-1
, rho-type GTPase-activating protein 8