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ARHGEF28 encodes a member of the Rho guanine nucleotide exchange factor family. Additionally we are shipping ARHGEF28 Antibodies (7) and and many more products for this protein.
results show that Rgnef functions as an effector of Galpha13 signaling and that this linkage may mediate FAK (show PTK2 ELISA Kits) activation in DLD (show DLD ELISA Kits)-1 colon carcinoma cells
This study showed that ARHGEF28 gene exon 6/intron 6 junction mutations in Chinese amyotrophic lateral sclerosis cohort.
Study identified a heterozygous mutation in amyotrophic lateral sclerosis patients that is predicted to generate a premature truncated ARHGEF28 gene product. There were extensive regions of homozygosity in the ARHGEF28 gene in two familial ALS patients.
This study demonistrated that RGNEF-immunoreactive neuronal cytoplasmic inclusions (NCIs) can co-localize with TDP-43 (show TARDBP ELISA Kits), FUS/TLS (show FUS ELISA Kits) and p62 (show GTF2H1 ELISA Kits) within spinal motor neurons.
Studies identify Rgnef as a novel regulator of colon carcinoma motility and invasion, and they show that a Rgnef-FAK (show PTK2 ELISA Kits) linkage promotes colon carcinoma progression in vivo.
RGNEF is a human homologue of p190RhoGEF, and its RNA is expressed in both brain and spinal cord
Rgnef promotes integrin beta 1-stimulated focal adhesion kinase activation.
An essential role for Rgnef in RhoA (show RHOA ELISA Kits) regulation downstream of integrins in control of cell migration.
STAT3 represents an essential effector pathway of Rho GTPases in regulating multiple cellular functions including actin cytoskeleton reorganization, cell migration, gene activation, and proliferation
This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants.
190 kDa guanine nucleotide exchange factor
, Rho interacting protein 2
, rho guanine nucleotide exchange factor 28
, rho-guanine nucleotide exchange factor
, Rho specific exchange factor
, Rho-guanine nucleotide exchange factor
, rho-interacting protein 2