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Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. Additionally we are shipping ARHGEF2 Proteins (6) and ARHGEF2 Kits (5) and many more products for this protein.
Showing 10 out of 72 products:
Dog (Canine) Monoclonal ARHGEF2 Primary Antibody for IHC (fro), IF - ABIN1105439
Aijaz, DAtri, Citi, Balda, Matter: Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transition. in Developmental cell 2005
Show all 4 references for ABIN1105439
Mouse (Murine) Polyclonal ARHGEF2 Primary Antibody for IF, IP - ABIN264980
Glaven, Whitehead, Bagrodia, Kay, Cerione: The Dbl-related protein, Lfc, localizes to microtubules and mediates the activation of Rac signaling pathways in cells. in The Journal of biological chemistry 1999
Study describes a new mode of GEF-H1 activation in response to G-protein-coupled receptor (GPCR (show TAS1R3 Antibodies)) ligands that is independent of microtubule depolymerization.
Data show that the activation of the microtubule-associated guanine nucleotide exchange factor (show ARHGEF12 Antibodies) GEF-H1, encoded by Arhgef2, is essential for sensing of foreign RNA by RIG-I (show DDX58 Antibodies)-like receptors.
Pak2 (show PAK2 Antibodies), but not Pak1 (show PAK1 Antibodies), negatively regulates RhoA (show RHOA Antibodies) via phosphorylation of the guanine nucleotide exchange factor (show ARHGEF12 Antibodies) GEF-H1 at an inhibitory site, leading to increased GEF-H1 microtubule binding and loss of RhoA (show RHOA Antibodies) stimulation
It was shown that the guanine exchange factors GEF-H1 and ECT2 (show ECT2 Antibodies) must be downregulated for megakaryote polyploidization. The first (2N-4N) endomitotic cycle requires GEF-H1 downregulation, whereas subsequent cycles (>4N) require ECT2 (show ECT2 Antibodies) downregulation.
CAPN6 (show CAPN6 Antibodies) acts as a regulator of Rac1 and cell motility through interaction with GEF-H1.
LARG is activated by the Src family tyrosine kinase Fyn, whereas GEF-H1 catalytic activity is enhanced by ERK downstream of a signalling cascade that includes FAK and Ras
p114-RhoGEF (show ARHGEF18 Antibodies) and Lfc are critically involved in Wnt-3a (show WNT3A Antibodies)- and Dvl (show DVL1 Antibodies)-induced RhoA (show RHOA Antibodies) activation and neurite retraction in N1E-115 cells.
Depletion of GEF-H1 in the murine two-hit model of VILI attenuated vascular leak induced by lung ventilation at high tidal volume and thrombin (show F2 Antibodies)-derived peptide TRAP6.
Enteropathogenic Escherichia coli type III effectors, EspG and its homolog Orf3, trigger the activation of the RhoA (show RHOA Antibodies)-ROCK signaling pathway via GEF-H1
PAK4 (show PAK4 Antibodies) mediates morphological changes through regulation of GEF-H1
Overexpression of miR (show MLXIP Antibodies)-194 downregulates the GEF-H1/RhoA (show RHOA Antibodies) pathway, inhibits melanoma cancer cell proliferation and metastasis. Furthermore, miR (show MLXIP Antibodies)-194 expression is negatively associated with tumor-node-metastasis (TNM (show ODZ1 Antibodies)) stages
data suggest that the induction of SGK1 (show SGK1 Antibodies) through treatment with dexamethasone alters MT dynamics to increase Sec5 (show EXOC2 Antibodies)-GEF-H1 interactions, which promote GEF-H1 targeting to adhesion sites.
this study reports the crystal structure of human GEF-H1 PH domain to 2.45 A resolution.
By stimulating cofilin (show CFL1 Antibodies)/PP2A (show PPP2R4 Antibodies)-mediated dephosphorylation of the guanine nucleotide exchange factor (show RASGRF1 Antibodies) GEF-H1.
regulation of c-Src trafficking requires both microtubules and actin polymerization, and GEF-H1 coordinates c-Src trafficking, acting as a molecular switch between these two mechanisms
Results supported that miR (show MLXIP Antibodies)-512-3p could inhibit tumor cell adhesion, migration, and invasion by regulating the RAC1 activity via DOCK3 (show DOCK3 Antibodies) in NSCLC A549 and H1299 cell lines.
TGF-beta (show TGFB1 Antibodies) regulates LARG (show ARHGEF12 Antibodies) and GEF-H1 during epithelial-mesenchymal transition to affect stiffening response to force and cell invasion.
Our findings underscore a potent oncogenic role for GEF-H1 in promoting the metastatic potentials of hepatocellular carcinoma, possibly through activation of RhoA (show RHOA Antibodies) signalling.
Paxillin (show PXN Antibodies)-GEF-H1-p42 (show EPB42 Antibodies)/44-MAPK (show MAPK1 Antibodies) module as a regulator of pathological mechanotransduction.
This study investigated a novel mechanism of vascular barrier protection by ANP (show NPPA Antibodies) via modulation of GEF-H1 function.
Data indicate that TNF-alpha (show TNF Antibodies) stimulates Rac (show AKT1 Antibodies), ADAM17/TACE (show ADAM17 Antibodies), and RhoA (show RHOA Antibodies) through the guanine nucleotide exchange factor (show ARHGEF12 Antibodies) (GEF)-H1.
Data indicate that GEF-H1 is a target and functional effector of TGF-beta (show TGFB1 Antibodies) by orchestrating Rho signaling to regulate gene expression and cell migration.
ERK/GEF-H1/Rho/ROK/pMLC pathway could be a central mechanism whereby electrogenic transmembrane transport processes control myosin phosphorylation and regulate paracellular transport in the tubular epithelium.
the ERK (show MAPK1 Antibodies)/GEF-H1/Rho/Rho kinase (show ROCK1 Antibodies)/phospho-MLC pathway is the mechanism mediating TNF-alpha (show TNF Antibodies)-induced elevation of tubular epithelial permeability, which in turn might contribute to kidney injury
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.
Rho/Rac guanine nucleotide exchange factor (GEF) 2
, guanine nucleotide exchange factor LFC
, Rho/Rac guanine nucleotide exchange factor 2
, rho guanine nucleotide exchange factor 2-like
, LBC'S first cousin
, guanine nucleotide exchange factor H1
, lymphoid blast crisis-like 1
, oncogene LFC
, rho guanine nucleotide exchange factor 2
, microtubule-regulated Rho-GEF
, proliferating cell nucleolar antigen p40
, Guanine nucleotide exchange factor H1
, rho/rac guanine nucleotide exchange factor 2
, tight junction-associated guanine nucleotide exchange factor