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anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) Antibodies

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. Additionally we are shipping ARHGEF2 Proteins (6) and ARHGEF2 Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ARHGEF2 16800 Q60875
ARHGEF2 9181 Q92974
ARHGEF2 310635 Q5FVC2
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Top anti-ARHGEF2 Antibodies at antibodies-online.com

Showing 10 out of 70 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mouse Sheep Un-conjugated IF, IP, WB 0.25 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-ARHGEF2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Human Placenta WB Suggested Anti-ARHGEF2  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: Human Placenta 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HeLa cells treated with TSA 400nM 24H and Jurkat cells treated with forskolin 40nM 30', using Rho/Rac Guanine Nucleotide Exchange Factor 2 (Phospho-Ser885) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Dog Mouse Un-conjugated IHC (fro), IF, IP, WB   0.1 mg Log in to see 6 to 8 Days
$643.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from NIH-3T3 cells, using Rho/Rac Guanine Nucleotide Exchange Factor 2 (Ab-885) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from RAW264.7 cells, using ARHGEF2 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: K562 5% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated WB Western blot analysis of GEF H1 expression in HeLa (A), NIH3T3 (B), H9C2 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human breast cancer labeled with Anti-Arhgef2/GEF H1 Polyclonal Antibody, Unconjugated (ABIN705161) followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated WB Western blot (WB) analysis of ARHGEF2 antibody in extracts from NIH cells. 0.1 mg Log in to see 6 to 8 Days
$390.50
Details

ARHGEF2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-ARHGEF2 Antibodies

  1. Dog (Canine) Monoclonal ARHGEF2 Primary Antibody for IHC (fro), IF - ABIN1105439 : Aijaz, DAtri, Citi, Balda, Matter: Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transition. in Developmental cell 2005 (PubMed)
    Show all 4 references for ABIN1105439

  2. Mouse (Murine) Polyclonal ARHGEF2 Primary Antibody for IF, IP - ABIN264980 : Glaven, Whitehead, Bagrodia, Kay, Cerione: The Dbl-related protein, Lfc, localizes to microtubules and mediates the activation of Rac signaling pathways in cells. in The Journal of biological chemistry 1999 (PubMed)

More Antibodies against ARHGEF2 Interaction Partners

Xenopus laevis rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) interaction partners

Mouse (Murine) rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) interaction partners

  1. Study describes a new mode of GEF-H1 activation in response to G-protein-coupled receptor (GPCR (show TAS1R3 Antibodies)) ligands that is independent of microtubule depolymerization.

  2. Data show that the activation of the microtubule-associated guanine nucleotide exchange factor (show ARHGEF12 Antibodies) GEF-H1, encoded by Arhgef2, is essential for sensing of foreign RNA by RIG-I (show DDX58 Antibodies)-like receptors.

  3. Pak2 (show PAK2 Antibodies), but not Pak1 (show PAK1 Antibodies), negatively regulates RhoA (show RHOA Antibodies) via phosphorylation of the guanine nucleotide exchange factor (show ARHGEF12 Antibodies) GEF-H1 at an inhibitory site, leading to increased GEF-H1 microtubule binding and loss of RhoA (show RHOA Antibodies) stimulation

  4. It was shown that the guanine exchange factors GEF-H1 and ECT2 (show ECT2 Antibodies) must be downregulated for megakaryote polyploidization. The first (2N-4N) endomitotic cycle requires GEF-H1 downregulation, whereas subsequent cycles (>4N) require ECT2 (show ECT2 Antibodies) downregulation.

  5. CAPN6 (show CAPN6 Antibodies) acts as a regulator of Rac1 and cell motility through interaction with GEF-H1.

  6. LARG is activated by the Src family tyrosine kinase Fyn, whereas GEF-H1 catalytic activity is enhanced by ERK downstream of a signalling cascade that includes FAK and Ras

  7. p114-RhoGEF (show ARHGEF18 Antibodies) and Lfc are critically involved in Wnt-3a (show WNT3A Antibodies)- and Dvl (show DVL1 Antibodies)-induced RhoA (show RHOA Antibodies) activation and neurite retraction in N1E-115 cells.

  8. Depletion of GEF-H1 in the murine two-hit model of VILI attenuated vascular leak induced by lung ventilation at high tidal volume and thrombin (show F2 Antibodies)-derived peptide TRAP6.

  9. Enteropathogenic Escherichia coli type III effectors, EspG and its homolog Orf3, trigger the activation of the RhoA (show RHOA Antibodies)-ROCK signaling pathway via GEF-H1

  10. PAK4 (show PAK4 Antibodies) mediates morphological changes through regulation of GEF-H1

Human rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) interaction partners

  1. data suggest that the induction of SGK1 (show SGK1 Antibodies) through treatment with dexamethasone alters MT dynamics to increase Sec5 (show EXOC2 Antibodies)-GEF-H1 interactions, which promote GEF-H1 targeting to adhesion sites.

  2. this study reports the crystal structure of human GEF-H1 PH domain to 2.45 A resolution.

  3. By stimulating cofilin (show CFL1 Antibodies)/PP2A (show PPP2R4 Antibodies)-mediated dephosphorylation of the guanine nucleotide exchange factor (show RASGRF1 Antibodies) GEF-H1.

  4. regulation of c-Src trafficking requires both microtubules and actin polymerization, and GEF-H1 coordinates c-Src trafficking, acting as a molecular switch between these two mechanisms

  5. Results supported that miR (show MLXIP Antibodies)-512-3p could inhibit tumor cell adhesion, migration, and invasion by regulating the RAC1 activity via DOCK3 (show DOCK3 Antibodies) in NSCLC A549 and H1299 cell lines.

  6. TGF-beta (show TGFB1 Antibodies) regulates LARG (show ARHGEF12 Antibodies) and GEF-H1 during epithelial-mesenchymal transition to affect stiffening response to force and cell invasion.

  7. Our findings underscore a potent oncogenic role for GEF-H1 in promoting the metastatic potentials of hepatocellular carcinoma, possibly through activation of RhoA (show RHOA Antibodies) signalling.

  8. Paxillin (show PXN Antibodies)-GEF-H1-p42 (show EPB42 Antibodies)/44-MAPK (show MAPK1 Antibodies) module as a regulator of pathological mechanotransduction.

  9. This study investigated a novel mechanism of vascular barrier protection by ANP (show NPPA Antibodies) via modulation of GEF-H1 function.

  10. The RhoGEF (show ARHGEF11 Antibodies) GEF-H1 is required for oncogenic RAS signaling via KSR-1 (show KSR1 Antibodies).

Pig (Porcine) rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) interaction partners

  1. Data indicate that TNF-alpha (show TNF Antibodies) stimulates Rac (show AKT1 Antibodies), ADAM17/TACE (show ADAM17 Antibodies), and RhoA (show RHOA Antibodies) through the guanine nucleotide exchange factor (show ARHGEF12 Antibodies) (GEF)-H1.

  2. Data indicate that GEF-H1 is a target and functional effector of TGF-beta (show TGFB1 Antibodies) by orchestrating Rho signaling to regulate gene expression and cell migration.

  3. ERK/GEF-H1/Rho/ROK/pMLC pathway could be a central mechanism whereby electrogenic transmembrane transport processes control myosin phosphorylation and regulate paracellular transport in the tubular epithelium.

  4. the ERK (show MAPK1 Antibodies)/GEF-H1/Rho/Rho kinase (show ROCK1 Antibodies)/phospho-MLC pathway is the mechanism mediating TNF-alpha (show TNF Antibodies)-induced elevation of tubular epithelial permeability, which in turn might contribute to kidney injury

ARHGEF2 Antigen Profile

Protein Summary

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with ARHGEF2

  • Rho/Rac guanine nucleotide exchange factor (GEF) 2 (ARHGEF2) antibody
  • Rho/Rac guanine nucleotide exchange factor (GEF) 2 (arhgef2) antibody
  • Rho/Rac guanine nucleotide exchange factor 2 (LOC100346634) antibody
  • rho/rac guanine nucleotide exchange factor (GEF) 2 (Arhgef2) antibody
  • AA408978 antibody
  • GEF antibody
  • GEF-H1 antibody
  • GEF-H1/LFC antibody
  • GEFH1 antibody
  • Lbcl1 antibody
  • Lfc antibody
  • LFP40 antibody
  • MGC75855 antibody
  • MGC82333 antibody
  • MGC86214 antibody
  • mKIAA0651 antibody
  • P40 antibody

Protein level used designations for ARHGEF2

Rho/Rac guanine nucleotide exchange factor (GEF) 2 , guanine nucleotide exchange factor LFC , Rho/Rac guanine nucleotide exchange factor 2 , rho guanine nucleotide exchange factor 2-like , LBC'S first cousin , guanine nucleotide exchange factor H1 , lymphoid blast crisis-like 1 , oncogene LFC , rho guanine nucleotide exchange factor 2 , rhobin , microtubule-regulated Rho-GEF , proliferating cell nucleolar antigen p40 , GEF-H1 , Guanine nucleotide exchange factor H1 , rho/rac guanine nucleotide exchange factor 2 , tight junction-associated guanine nucleotide exchange factor

GENE ID SPECIES
100057582 Equus caballus
398353 Xenopus laevis
407848 Xenopus (Silurana) tropicalis
457378 Pan troglodytes
719369 Macaca mulatta
100346634 Oryctolagus cuniculus
100434709 Pongo abelii
100601565 Nomascus leucogenys
16800 Mus musculus
9181 Homo sapiens
310635 Rattus norvegicus
403498 Canis lupus familiaris
100145887 Sus scrofa
505940 Bos taurus
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