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The protein encoded by RHOBTB1 belongs to the Rho family of the small GTPase superfamily. Additionally we are shipping RHOBTB1 Proteins (5) and RHOBTB1 Kits (1) and many more products for this protein.
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Cow (Bovine) Polyclonal RHOBTB1 Primary Antibody for IHC, WB - ABIN2777046
Beder, Gunduz, Ouchida, Gunduz, Sakai, Fukushima, Nagatsuka, Ito, Honjo, Nishizaki, Shimizu: Identification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and neck cancer. in Journal of cancer research and clinical oncology 2005
we found that miR (show MLXIP Antibodies)-31 acts as an oncogene (show RAB1A Antibodies) in colon cancer and identified RhoBTB1 as a new target of miR (show MLXIP Antibodies)-31 further study demonstrated that miR (show MLXIP Antibodies)-31 contributed to the development of colon cancer at least partly by targeting RhoBTB1.
Frequent allelic loss and decreased expression of RHOBTB1 suggested that this gene has a role in tumorigenesis of a subset of HNSCC (Head-Neck Squamous Cell Carcinoma).
The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants.
rho-related BTB domain-containing protein 1
, Rho-related BTB domain containing 1
, rho-related BTB domain-containing protein 1-like