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The protein encoded by RHOBTB2 is a small Rho GTPase and a candidate tumor suppressor. Additionally we are shipping rho-Related BTB Domain Containing 2 Antibodies (13) and many more products for this protein.
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Mutation in the promoter and exon 7 of DBC2 gene is not common in the Chinese population and may not contribute to the susceptibility for breast cancer in China
data suggest a new paradigm for Hsp90 (show HSP90 Proteins)-modulated assembly of a Cul3 (show CUL3 Proteins)/DBC2 E3 ubiquitin ligase (show MUL1 Proteins) complex that may extend to other E3 ligase complexes.
). The results demonstrated that aberrant methylation of RhoBTB2 may be responsible for the suppression of RhoBTB2 mRNA expression in breast cancer, a significant event during the genesis of breast cancer that correlated with progesterone receptor (show PGR Proteins) status
Thus loss of DBC2 expression is caused by abnormal methylation of DBC2 and might have a role in breast cancer development.
Loss of DBC2 expression is an early and progressive event in the development of lung adenocarcinoma.
Overexpression of RhoBTB2 in breast tumor cells significantly inhibited the proliferation and colony formation of tumor cells. In addition, RhoBTB2 also elevated the apoptotic ratio and caused typical changes of apoptotic morphology.
RhoBTB2 is establishing itself as a tumor suppressor with increasing relevance towards malignancies.
Ectopic expression of RhoBTB2 results in decreased phosphorylation of ezrin (show EZR Proteins) and Akt2 (show AKT2 Proteins) in both MDA-MB-231 and MDA-MB-435 cells.
The expression of Fas (show FAS Proteins), CTLA-4 (show CTLA4 Proteins) and RhoBTB2 at the mRNA level is involved in genesis and progression of breast cancer.
Frequent loss of RhoBTB2 expression is associated with sporadic breast cancer.
There is no connection between elevated expression of mDbc2/Rhobtb2 and a specific stage of mammary gland development, but this gene plays a critical role in the development of the nervous system.
The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene.
tumor necrosis factor receptor superfamily member 10B
, rho-related BTB domain-containing protein 2
, Rho-related BTB domain containing 2
, subgroup E ALV receptor
, rho-related BTB domain-containing protein 2-like
, deleted in breast cancer 2 gene protein
, deleted in breast cancer 2 gene protein homolog