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anti-serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) Antibodies

SPTLC2 encodes a long chain base subunit of serine palmitoyltransferase. Additionally we are shipping serine Palmitoyltransferase, Long Chain Base Subunit 2 Kits (4) and serine Palmitoyltransferase, Long Chain Base Subunit 2 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SPTLC2 630537  
SPTLC2 300272  
SPTLC2 9517 O15270
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Top anti-serine Palmitoyltransferase, Long Chain Base Subunit 2 Antibodies at antibodies-online.com

Showing 10 out of 70 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-SPTLC2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB SPTLC2 Antibody (Center) (ABIN1881828) western blot analysis in HepG2 cell line lysates (35 µg/lane). This demonstrates the SPTLC2 antibody detected the SPTLC2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$500.50
Details
Human Mouse Un-conjugated ELISA, WB SPTLC2 polyclonal antibody (A01), Lot # 051123JC01. Western Blot analysis of SPTLC2 expression in Raw 264.7. (65kDa,OMIM,http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=605720) SPTLC2 polyclonal antibody (A01), Lot # 051123JC01. Western Blot analysis of SPTLC2 expression in NIH/3T3. (65kDa,OMIM,http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=605722) 50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated WB SPTLC2 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details
Human Rabbit Un-conjugated IHC, WB 0.1 mL Log in to see 2 to 3 Days
$481.25
Details
Human Rabbit Alkaline Phosphatase (AP) ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details

SPTLC2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-serine Palmitoyltransferase, Long Chain Base Subunit 2 Antibodies

  1. Human Polyclonal SPTLC2 Primary Antibody for WB - ABIN1881828 : Rotthier, Auer-Grumbach, Janssens, Baets, Penno, Almeida-Souza, Van Hoof, Jacobs, De Vriendt, Schlotter-Weigel, Löscher, Vondráček, Seeman: Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type I. in American journal of human genetics 2010 (PubMed)
    Show all 5 references for ABIN1881828

  2. Human Polyclonal SPTLC2 Primary Antibody for EIA, WB - ABIN357774 : Stachowitz, Alessandrini, Abeck, Ring, Behrendt: Permeability barrier disruption increases the level of serine palmitoyltransferase in human epidermis. in The Journal of investigative dermatology 2002 (PubMed)
    Show all 5 references for ABIN357774

  3. Chicken Polyclonal SPTLC2 Primary Antibody for WB - ABIN2783451 : Hornemann, Wei, von Eckardstein: Is the mammalian serine palmitoyltransferase a high-molecular-mass complex? in The Biochemical journal 2007 (PubMed)

  4. Human Polyclonal SPTLC2 Primary Antibody for ELISA, WB - ABIN564104 : Wang, Robinet, Smith, Gulshan: ORMDL orosomucoid-like proteins are degraded by free-cholesterol-loading-induced autophagy. in Proceedings of the National Academy of Sciences of the United States of America 2015 (PubMed)

More Antibodies against serine Palmitoyltransferase, Long Chain Base Subunit 2 Interaction Partners

Mouse (Murine) serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) interaction partners

  1. The expression of SPT2 was stronger in vascular smooth muscle cells and neointima of carotid arteries from knock-out mice compared to wild-type.

  2. Data suggest that overexpression of serine palmitoyltransferase (Sptlc1 (show SPTLC1 Antibodies) and Sptlc2, serine palmitoyltransferase long chain base subunit 1 (show SPTLC1 Antibodies)/2) to elevate de novo sphingolipid biosynthesis induces autophagy in the liver.

  3. SPTLC2 knockout mice showed decreased ceramide levels in the epidermis, which impaired water-holding capacity and barrier function.

  4. Ldlr (show LDLR Antibodies) gene knockout mice with myeloid cell-specific Sptlc2 haploinsufficiency exhibited significantly less atherosclerosis than controls.

  5. Data show that LCAT (show LCAT Antibodies) activity was significantly higher in long chain base biosynthesis protein 2 (Sptlc2)+/- and sphingomyelin synthase 2 (Sms2 (show SGMS2 Antibodies))-/- mice, but markedly lower in ApoE (show APOE Antibodies)-/- and Ldlr (show LDLR Antibodies)-/- mice.

  6. results suggest that Sptlc2-mediated de novo ceramide synthesis is an essential source of C18 (show BBS9 Antibodies):0 and very long chain, but not of shorter chain, ceramides in the heart

  7. Inflammatory response elicited by lipopolysaccharide increases serine palmitoyltransferase activity via upregulation of Sptlc2 in macrophages.

  8. Deficiency of Sptlc2 induces necrotic lesions in gastrointestinal cells followed by atrophic change of the tissue in short term.

  9. Both Sptlc1 (show SPTLC1 Antibodies) and Sptlc2 interactions are necessary for Serine palmitoyl-CoA transferase (SPT (show AGXT Antibodies)) activity in vivo and SPT (show AGXT Antibodies) activity directly influences plasma sphingolipid levels

  10. The expression and activities of SPT (show AGXT Antibodies) in mouse liver increased significantly following fumonisin B1 treatment.

Human serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) interaction partners

  1. The activities of the hLCB2a mutants were measured in the presence of ssSPTa and ssSPTb and was found that all decrease enzyme activity.

  2. Mutations in SPTLC2 are associated with increased deoxySL formation causing hereditary sensory and autonomic neuropathy type 1 (HSANI) in a familial study.

  3. Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type I.

  4. results suggest that SPTLC2 mutations are not a common cause for genetic sensory neuropathies.

  5. Results suggest that functional serine palmitoyltransferase is not a dimer, but a higher organized complex, composed of three distinct subunits (SPTLC1 (show SPTLC1 Antibodies), SPTLC2 and SPTLC3 (show SPTLC3 Antibodies)) with a molecular mass of 480 kDa.

  6. discovery of 2 proteins, ssSPTa and ssSPTb, which each interacts with both hLCB1 (show SPTLC1 Antibodies) and hLCB2, suggesting that there are 4 distinct human SPT (show AGXT Antibodies) isozymes.

serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) Antigen Profile

Protein Summary

This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I.

Gene names and symbols associated with SPTLC2

  • serine palmitoyltransferase, long chain base subunit 2 (SPTLC2) antibody
  • serine palmitoyltransferase, long chain base subunit 2 (sptlc2) antibody
  • demilune cell and parotid protein 2 (Dcpp2) antibody
  • salivary protein 2 (Spt2) antibody
  • serine palmitoyltransferase LCB2 subunit (LOC100689415) antibody
  • serine palmitoyltransferase, long chain base subunit 2 (Sptlc2) antibody
  • serine palmitoyltransferase, long chain base subunit 2a (sptlc2a) antibody
  • AI173915 antibody
  • Dcpp-2 antibody
  • EG630537 antibody
  • hLCB2a antibody
  • HSN1C antibody
  • LCB2 antibody
  • LCB2A antibody
  • mKIAA0526 antibody
  • NSAN1C antibody
  • Pomt2 antibody
  • SPT-2 antibody
  • SPT2 antibody
  • sptlc2 antibody
  • zgc:110661 antibody

Protein level used designations for SPTLC2

serine palmitoyltransferase, long chain base subunit 2 , serine palmitoyltransferase 2-like , sublingual parotid tongue-2 salivary protein , LCB 2 , Long chain base biosynthesis protein 2 , Long chain base biosynthesis protein 2a , SPT 2 , Serine-palmitoyl-CoA transferase 2 , serine palmitoyltransferase 2 , long chain base biosynthesis protein 2a , serine palmitoyltransferase, subunit II , serine-palmitoyl-CoA transferase 2 , LCB2a , long chain base biosynthesis protein 2 , protein-O-mannosyltransferase 2

GENE ID SPECIES
100059392 Equus caballus
100446763 Pongo abelii
100464437 Ailuropoda melanoleuca
100566142 Anolis carolinensis
100601824 Nomascus leucogenys
630537 Mus musculus
300272 Rattus norvegicus
100689415 Cricetulus griseus
9517 Homo sapiens
20773 Mus musculus
100158010 Sus scrofa
101115373 Ovis aries
366697 Rattus norvegicus
444190 Xenopus laevis
423379 Gallus gallus
480403 Canis lupus familiaris
537972 Bos taurus
553646 Danio rerio
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