anti-serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) Antibodies

The protein encoded by SPINK1 is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. Additionally we are shipping serine Peptidase Inhibitor, Kazal Type 1 Kits (21) and serine Peptidase Inhibitor, Kazal Type 1 Proteins (18) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SPINK1 266602 P09656
SPINK1 6690 P00995
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Top anti-serine Peptidase Inhibitor, Kazal Type 1 Antibodies at antibodies-online.com

Showing 10 out of 71 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB <b>WB Suggested Anti-SPINK1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>MCF7 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IC, IF, WB Immunofluorescent analysis of SPINK1 staining in Hela cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody Western blot analysis of SPINK1 expression in mouse intestine (A) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Rat Rabbit Un-conjugated IF (p), IHC (p) Antigen: 0.2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Goat-Anti-Rabbit IgG at 1: 5000; TMB staining; Read the data in MicroplateReader by 450 Formalin-fixed and paraffin embedded rat pancreas labeled with Anti-SPINK1 Polyclonal Antibody, Unconjugated (ABIN681658) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$295.90
Details
Human Rabbit Un-conjugated IHC (p) 7 mL Log in to see 21 to 31 Days
$385.00
Details
Human Mouse Un-conjugated IHC (p), IP, ELISA, WB Immunoperoxidase of monoclonal antibody to SPINK1 on formalin-fixed paraffin-embedded human pancreas. [antibody concentration 1 ug/ml] SPINK1 monoclonal antibody (M01), clone 4D4. Western Blot analysis of SPINK1 expression in human pancreas. 100 μg Log in to see 11 to 12 Days
$430.00
Details
Human Mouse Un-conjugated IF, IHC (p), IP, WB 50 μg Log in to see 6 to 8 Days
$566.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated IHC (p), WB 1 mL Log in to see 21 to 31 Days
$672.00
Details
Rat Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Rat Rabbit Cy5.5 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details

SPINK1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-serine Peptidase Inhibitor, Kazal Type 1 Antibodies

  1. Human Monoclonal SPINK1 Primary Antibody for IHC (p), IP - ABIN562978 : Tomlins, Rhodes, Yu, Varambally, Mehra, Perner, Demichelis, Helgeson, Laxman, Morris, Cao, Cao, Andrén, Fall, Johnson, Wei, Shah, Al-Ahmadie, Eastham, Eggener, Fine, Hotakainen, Stenman, Tsodikov et al.: The role of SPINK1 in ETS rearrangement-negative prostate cancers. ... in Cancer cell 2008 (PubMed)
    Show all 8 Pubmed References

More Antibodies against serine Peptidase Inhibitor, Kazal Type 1 Interaction Partners

Human serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) interaction partners

  1. SPINK1 can associate with EGFR to promote the expression of cell proliferation-related and anti-apoptosis-related genes/proteins; inhibit the expression of pro-apoptosis-related genes/proteins via p38, ERK, and JNK pathways; and consequently promote the proliferation of BRL-3A cells.

  2. The present study demonstrates for the first time that both fibroblast-derived and recombinant IL-6 (show IL6 Antibodies) induces SPINK1 expression and secretion in in colorectal adenocarcinoma.

  3. Absolute exclusivity between SPINK1 overexpression and homozygous PTEN (show PTEN Antibodies) deletion in localized PCA (show FLVCR1 Antibodies).

  4. It is the first time to simultaneously detect SPINK1 and ERG expression in initially diagnosed bone metastatic prostate cancer. The over-expression of SPINK1 was not only related to poor PSA response, but also significantly associated with the occurrence of castration-resistant prostate cancer, especially in those with much more aggressive phenotype

  5. We describe a case of malignant pancreatic cancer diagnosed in a young patient with chronic pancreatitis who is a SPINK 1 heterozygote gene mutation carrier

  6. Mutations in CFTR (show CFTR Antibodies), SPINK1 or PRSS1 (show PRSS1 Antibodies) are present in one third of pediatric acute recurrent (ARP (show CRISP1 Antibodies)) or chronic (CP) pancreatitis with no other cause.

  7. TATI proved to be a sensitive indicator of disease recurrence and distant metastasis, with a sensitivity of 84.4% and 75.7%, respectively.

  8. Sixteen patients exhibited heterozygous pathogenic variants of SPINK1, including c.194+2T>C (n=12), p.N34S (n=3), and a novel pathogenic splicing variation c.194+1G>A.

  9. Data indicate that SPINK1 expression status shows a lower rate of concordance between primary prostate cancer (PCA (show FLVCR1 Antibodies)) site and nodule metastases, than those of ERG (show ERG Antibodies) and PTEN (show PTEN Antibodies).

  10. Approx 25% of discontinuously involved prostate biopsy cores showed tumor foci with discordant ERG (show ERG Antibodies)/SPINK1 status, consistent with multiclonal disease.

Cow (Bovine) serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) interaction partners

  1. Partially folded bovine pancreatic trypsin inhibitor analogues attain fully native structures when co-crystallized with S195A rat trypsin.

serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) Antigen Profile

Protein Summary

The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis.

Gene names and symbols associated with SPINK1

  • serine peptidase inhibitor, Kazal type 1 (SPINK1) antibody
  • pancreatic secretory trypsin inhibitor-like (LOC100622575) antibody
  • serine peptidase inhibitor, Kazal type 1 (Spink1) antibody
  • serine peptidase inhibitor, Kazal type 3 (Spink3) antibody
  • PCTT antibody
  • PSTI antibody
  • Psti-1 antibody
  • Spink1 antibody
  • Spink3 antibody
  • TATI antibody
  • TCP antibody
  • Tilp antibody

Protein level used designations for SPINK1

serine peptidase inhibitor, Kazal type 1 , serine protease inhibitor, Kazal type 1 , PSTI-II , calcium transport inhibitor , caltrin , pancreatic secretory trypsin inhibitor II , pancreatic secretory trypsin inhibitor type II (PSTI-II) , serine peptidase inhibitor, Kazal type 3 , serine protease inhibitor Kazal-type 3 , serine protease inhibitor, Kazal type 3 , pancreatic secretory trypsin inhibitor , serine protease inhibitor Kazal-type 1 , tumor-associated trypsin inhibitor , PSTI-I , Serine protease inhibitor kanzal type 1/ Trypsin inhibitor-like protein pancreatic , Serine protease inhibitor, kanzal type 1/ Trypsin inhibitor-like protein, pancreatic , cholecystokinin-releasing peptide , monitor peptide , pancreatic cholecystokinin(CCK) releasing peptide , pancreatic secretory trypsin inhibitor I , trypsin inhibitor-like protein, pancreatic

GENE ID SPECIES
740785 Pan troglodytes
100622575 Sus scrofa
266602 Rattus norvegicus
6690 Homo sapiens
574092 Bos taurus
608433 Canis lupus familiaris
101115618 Ovis aries
24833 Rattus norvegicus
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