serine Peptidase Inhibitor, Kazal Type 1 Proteins (SPINK1)

The protein encoded by SPINK1 is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. Additionally we are shipping serine Peptidase Inhibitor, Kazal Type 1 Antibodies (71) and serine Peptidase Inhibitor, Kazal Type 1 Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SPINK1 266602 P09656
SPINK1 6690 P00995
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Top serine Peptidase Inhibitor, Kazal Type 1 Proteins at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Yeast Horse His tag   1 mg Log in to see 60 to 71 Days
$2,038.67
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Yeast Wild boar His tag   1 mg Log in to see 60 to 71 Days
$2,038.67
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,053.33
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HOST_Mammalian Cells Human His tag   50 μg Log in to see 4 Days
$385.00
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HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 15 to 18 Days
$685.00
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HOST_Human Human His tag   10 μg Log in to see 15 to 16 Days
$225.00
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HOST_HEK-293 Cells Human Un-conjugated Validation with Western Blot 10 μg Log in to see 12 to 15 Days
$345.35
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details

SPINK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human , , , , ,
, ,

More Proteins for serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) Interaction Partners

Human serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) interaction partners

  1. SPINK1 can associate with EGFR to promote the expression of cell proliferation-related and anti-apoptosis-related genes/proteins; inhibit the expression of pro-apoptosis-related genes/proteins via p38, ERK, and JNK pathways; and consequently promote the proliferation of BRL-3A cells.

  2. The present study demonstrates for the first time that both fibroblast-derived and recombinant IL-6 (show IL6 Proteins) induces SPINK1 expression and secretion in in colorectal adenocarcinoma.

  3. Absolute exclusivity between SPINK1 overexpression and homozygous PTEN deletion in localized PCA (show FLVCR1 Proteins).

  4. It is the first time to simultaneously detect SPINK1 and ERG expression in initially diagnosed bone metastatic prostate cancer. The over-expression of SPINK1 was not only related to poor PSA response, but also significantly associated with the occurrence of castration-resistant prostate cancer, especially in those with much more aggressive phenotype

  5. We describe a case of malignant pancreatic cancer diagnosed in a young patient with chronic pancreatitis who is a SPINK 1 heterozygote gene mutation carrier

  6. Mutations in CFTR (show CFTR Proteins), SPINK1 or PRSS1 (show PRSS1 Proteins) are present in one third of pediatric acute recurrent (ARP (show CRISP1 Proteins)) or chronic (CP) pancreatitis with no other cause.

  7. TATI proved to be a sensitive indicator of disease recurrence and distant metastasis, with a sensitivity of 84.4% and 75.7%, respectively.

  8. Sixteen patients exhibited heterozygous pathogenic variants of SPINK1, including c.194+2T>C (n=12), p.N34S (n=3), and a novel pathogenic splicing variation c.194+1G>A.

  9. Data indicate that SPINK1 expression status shows a lower rate of concordance between primary prostate cancer (PCA) site and nodule metastases, than those of ERG and PTEN.

  10. Approx 25% of discontinuously involved prostate biopsy cores showed tumor foci with discordant ERG (show ERG Proteins)/SPINK1 status, consistent with multiclonal disease.

Cow (Bovine) serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) interaction partners

  1. Partially folded bovine pancreatic trypsin inhibitor analogues attain fully native structures when co-crystallized with S195A rat trypsin.

serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) Protein Profile

Protein Summary

The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis.

Gene names and symbols associated with SPINK1

  • serine peptidase inhibitor, Kazal type 1 (SPINK1)
  • pancreatic secretory trypsin inhibitor-like (LOC100622575)
  • serine peptidase inhibitor, Kazal type 1 (Spink1)
  • serine peptidase inhibitor, Kazal type 3 (Spink3)
  • PCTT protein
  • PSTI protein
  • Psti-1 protein
  • Spink1 protein
  • Spink3 protein
  • TATI protein
  • TCP protein
  • Tilp protein

Protein level used designations for SPINK1

serine peptidase inhibitor, Kazal type 1 , serine protease inhibitor, Kazal type 1 , PSTI-II , calcium transport inhibitor , caltrin , pancreatic secretory trypsin inhibitor II , pancreatic secretory trypsin inhibitor type II (PSTI-II) , serine peptidase inhibitor, Kazal type 3 , serine protease inhibitor Kazal-type 3 , serine protease inhibitor, Kazal type 3 , pancreatic secretory trypsin inhibitor , serine protease inhibitor Kazal-type 1 , tumor-associated trypsin inhibitor , PSTI-I , Serine protease inhibitor kanzal type 1/ Trypsin inhibitor-like protein pancreatic , Serine protease inhibitor, kanzal type 1/ Trypsin inhibitor-like protein, pancreatic , cholecystokinin-releasing peptide , monitor peptide , pancreatic cholecystokinin(CCK) releasing peptide , pancreatic secretory trypsin inhibitor I , trypsin inhibitor-like protein, pancreatic

GENE ID SPECIES
740785 Pan troglodytes
100622575 Sus scrofa
266602 Rattus norvegicus
6690 Homo sapiens
574092 Bos taurus
608433 Canis lupus familiaris
101115618 Ovis aries
24833 Rattus norvegicus
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