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anti-serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2) Antibodies

SPINT2 encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. Additionally we are shipping SPINT2 Proteins (14) and SPINT2 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SPINT2 292770  
SPINT2 10653 O43291
SPINT2 20733 Q9WU03
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Top anti-SPINT2 Antibodies at antibodies-online.com

Showing 10 out of 81 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Goat Un-conjugated EIA, WB AP21514PU-N SPINT2 Antibody staining of Human Placenta lysate at 0.3 µg/ml (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-SPINT2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: OVCAR-3 cell lysate WB Suggested Anti-SPINT2  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: OVCAR-3 cell lysate  SPINT2 is supported by BioGPS gene expression data to be expressed in OVCAR3 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated WB KCNE2 Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the KCNE2 antibody detected the KCNE2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated IHC (p), ELISA, WB Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB SPINT2 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details

SPINT2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus)


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Top referenced anti-SPINT2 Antibodies

  1. Human Polyclonal SPINT2 Primary Antibody for WB - ABIN2773946 : Generali, Fox, Berruti, Moore, Brizzi, Patel, Allevi, Bonardi, Aguggini, Bersiga, Campo, Dogliotti, Bottini, Harris: Regulation of hepatocyte growth factor activator inhibitor 2 by hypoxia in breast cancer. in Clinical cancer research : an official journal of the American Association for Cancer Research 2007 (PubMed)

  2. Cow (Bovine) Polyclonal SPINT2 Primary Antibody for EIA, WB - ABIN568704 : Sivagnanam, Janecke, Müller, Heinz-Erian, Taylor, Bird: Case of syndromic tufting enteropathy harbors SPINT2 mutation seen in congenital sodium diarrhea. in Clinical dysmorphology 2009 (PubMed)

More Antibodies against SPINT2 Interaction Partners

Human serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2) interaction partners

  1. study the methylation status of the promoter region of Serine peptidase inhibitor/hepatocyte growth factor activator inhibitor type 2 (SPINT2/HAI-2)

  2. It suggests an involvement of SPINT2 in PCa (show FLVCR1 Antibodies) tumorigenesis, probably in association with a post-translational regulation of SPINT2.

  3. N-glycan branching regulates HAI-2 through different subcellular distribution and subsequently access to different target proteases

  4. Matriptase (show ST14 Antibodies) inhibition by HAI-2 requires the translocation of HAI-2 to the cell surface, a process which is observed in some breast cancer cells but not in mammary epithelial cells.

  5. Epigenetic silencing of SPINT2 promotes cancer cell motility in malignant melanoma.

  6. a missense mutation in the serine protease inhibitor SPINT2 may have a role in congenital sodium diarrhea

  7. results suggest that the SPINT2 underexpression in the MSC (show MSC Antibodies) from MDS (show PAFAH1B1 Antibodies) patients is probably involved in the adhesion of progenitors to the bone marrow niche, through an increased HGF (show HGF Antibodies) and SDF-1 (show CXCL12 Antibodies) signaling pathway.

  8. The role of hepatocyte growth factor activator (show HGFA Antibodies) inhibitor-2 (HAI-2) in prostate cancer cell migration, invasion, tumorigenicity and metastasis.

  9. The tumor suppressor gene SPINT2 is commonly silenced by promoter hypermethylation in human esophageal squamous cell carcinoma and SPINT2 hypermethylation is correlated with poor overall survival.

  10. established SPINT2 as a second gene associated with congenital tufting enteropathy

Mouse (Murine) serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2) interaction partners

  1. HAI-1 (show SPINT1 Antibodies) regulates the activity of activated matriptase (show ST14 Antibodies), whereas HAI-2 has an essential role in regulating prostasin (show PRSS8 Antibodies)-dependent matriptase (show ST14 Antibodies) zymogen activation.

  2. mutations in Prss8 (show PRSS8 Antibodies) restored placentation and normal development of HAI-1 (show SPINT1 Antibodies)-deficient embryos and prevented early embryonic lethality, mid-gestation lethality due to placental labyrinth failure, and neural tube defects in HAI-2-deficient embryos.

  3. HAI-1 (show SPINT1 Antibodies) and -2 are overexpressed in the liver in cholangiopathies with ductular reactions and are possibly involved in liver fibrosis and hepatic differentiation.

  4. Unlike HAI-1 (show SPINT1 Antibodies) and matriptase (show ST14 Antibodies), HAI-2 expression is detected in non-epithelial cells of brain and lymph nodes, suggesting that HAI-2 may also be involved in inhibition of serine proteases other than matriptase (show ST14 Antibodies)

  5. Inhibition of the transmembrane serine protease (show F2 Antibodies) matriptase (show ST14 Antibodies) (encoded by St14 (show ST14 Antibodies)) is an essential function of HAI2 during tissue morphogenesis.

SPINT2 Antigen Profile

Protein Summary

This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SPINT2

  • serine peptidase inhibitor, Kunitz type, 2 (Spint2) antibody
  • serine peptidase inhibitor, Kunitz type, 2 (SPINT2) antibody
  • serine protease inhibitor, Kunitz type 2 (Spint2) antibody
  • AL024025 antibody
  • C76321 antibody
  • DIAR3 antibody
  • HAI-2 antibody
  • HAI2 antibody
  • Kop antibody
  • PB antibody

Protein level used designations for SPINT2

hepatocyte growth factor activator inhibitor type 2 , placental bikunin , serine protease inhibitor, Kunitz type 2 , kunitz-type protease inhibitor 2 , serine protease inhibitor, Kunitz type, 2

GENE ID SPECIES
292770 Rattus norvegicus
10653 Homo sapiens
20733 Mus musculus
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