anti-serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2) Antibodies

SPINT2 encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. Additionally we are shipping SPINT2 Proteins (17) and SPINT2 Kits (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SPINT2 292770  
SPINT2 10653 O43291
SPINT2 20733 Q9WU03
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Top anti-SPINT2 Antibodies at antibodies-online.com

Showing 10 out of 100 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SPINT2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: OVCAR-3 cell lysate SPINT2 is supported by BioGPS gene expression data to be expressed in OVCAR3 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-SPINT2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>THP-1 cell lysate WB Suggested Anti-SPINT2 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500 <br /> Positive Control: THP-1 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB Western Blot: HAI-2/SPINT2 Antibody [NBP2-26109] - Staining of Human Placenta lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$408.19
Details
Cow Goat Un-conjugated EIA, WB   0.1 mg Log in to see 12 to 15 Days
$375.38
Details
Human Goat Un-conjugated ELISA, WB Western Blot: HAI-2/SPINT2 Antibody [NBP1-52068] - NBP1-52068 (0.3ug/ml) staining of Human Placenta lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$408.19
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: SPINT2 Antibody [NBP1-83299] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY412085) Immunohistochemistry-Paraffin: SPINT2 Antibody [NBP1-83299] - Staining of human placenta shows distinct membranous and moderate cytoplasmic positivity in trophoblastic cells. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$481.25
Details
Human Rabbit Un-conjugated WB KCNE2 Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the KCNE2 antibody detected the KCNE2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details

SPINT2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus)
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Top referenced anti-SPINT2 Antibodies

  1. Human Polyclonal SPINT2 Primary Antibody for ELISA, WB - ABIN4316550 : Sivagnanam, Janecke, Müller, Heinz-Erian, Taylor, Bird: Case of syndromic tufting enteropathy harbors SPINT2 mutation seen in congenital sodium diarrhea. in Clinical dysmorphology 2009 (PubMed)

  2. Human Polyclonal SPINT2 Primary Antibody for IHC, IHC (p) - ABIN4316551 : Friis, Sales, Schafer, Vogel, Kataoka, Bugge: The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin. in The Journal of biological chemistry 2014 (PubMed)

More Antibodies against SPINT2 Interaction Partners

Human serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2) interaction partners

  1. Our data indicate that hypoxic inhibition of JMJD3 (show Kdm6b Antibodies) activity reduces demethylation of H3K27me3, nucleosome removal, and hence induction of the STAT6 (show STAT6 Antibodies) target gene CCL18 (show CCL18 Antibodies), while induction of other STAT6 (show STAT6 Antibodies)-inducible genes such as SPINT2 remained unaffected by JMJD3 (show Kdm6b Antibodies).

  2. Concomitant presence of TMPRSS13 (show TMPRSS13 Antibodies) with HAI-2 mediates phosphorylation of residues in the intracellular domain of the protease, and it coincides with efficient transport of the protease to the cell surface and its subsequent shedding.

  3. This study presented a molecular characterization of congenital tufting enteropathy Italian patients, and identified one mutation in the SPINT2 gene

  4. study the methylation status of the promoter region of Serine peptidase inhibitor/hepatocyte growth factor activator inhibitor type 2 (SPINT2/HAI-2)

  5. It suggests an involvement of SPINT2 in PCa (show FLVCR1 Antibodies) tumorigenesis, probably in association with a post-translational regulation of SPINT2.

  6. N-glycan branching regulates HAI-2 through different subcellular distribution and subsequently access to different target proteases

  7. Matriptase (show ST14 Antibodies) inhibition by HAI-2 requires the translocation of HAI-2 to the cell surface, a process which is observed in some breast cancer cells but not in mammary epithelial cells.

  8. Epigenetic silencing of SPINT2 promotes cancer cell motility in malignant melanoma.

  9. a missense mutation in the serine protease inhibitor SPINT2 may have a role in congenital sodium diarrhea

  10. results suggest that the SPINT2 underexpression in the MSC (show MSC Antibodies) from MDS (show PAFAH1B1 Antibodies) patients is probably involved in the adhesion of progenitors to the bone marrow niche, through an increased HGF (show HGF Antibodies) and SDF-1 (show CXCL12 Antibodies) signaling pathway.

Mouse (Murine) serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2) interaction partners

  1. HAI-1 (show SPINT1 Antibodies) regulates the activity of activated matriptase (show ST14 Antibodies), whereas HAI-2 has an essential role in regulating prostasin (show PRSS8 Antibodies)-dependent matriptase (show ST14 Antibodies) zymogen activation.

  2. mutations in Prss8 (show PRSS8 Antibodies) restored placentation and normal development of HAI-1 (show SPINT1 Antibodies)-deficient embryos and prevented early embryonic lethality, mid-gestation lethality due to placental labyrinth failure, and neural tube defects in HAI-2-deficient embryos.

  3. HAI-1 (show SPINT1 Antibodies) and -2 are overexpressed in the liver in cholangiopathies with ductular reactions and are possibly involved in liver fibrosis and hepatic differentiation.

  4. Unlike HAI-1 (show SPINT1 Antibodies) and matriptase (show ST14 Antibodies), HAI-2 expression is detected in non-epithelial cells of brain and lymph nodes, suggesting that HAI-2 may also be involved in inhibition of serine proteases other than matriptase (show ST14 Antibodies)

  5. Inhibition of the transmembrane serine protease (show F2 Antibodies) matriptase (show ST14 Antibodies) (encoded by St14 (show ST14 Antibodies)) is an essential function of HAI2 during tissue morphogenesis.

SPINT2 Antigen Profile

Protein Summary

This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SPINT2

  • serine peptidase inhibitor, Kunitz type, 2 (Spint2) antibody
  • serine peptidase inhibitor, Kunitz type, 2 (SPINT2) antibody
  • serine protease inhibitor, Kunitz type 2 (Spint2) antibody
  • AL024025 antibody
  • C76321 antibody
  • DIAR3 antibody
  • HAI-2 antibody
  • HAI2 antibody
  • Kop antibody
  • PB antibody

Protein level used designations for SPINT2

hepatocyte growth factor activator inhibitor type 2 , placental bikunin , serine protease inhibitor, Kunitz type 2 , kunitz-type protease inhibitor 2 , serine protease inhibitor, Kunitz type, 2

GENE ID SPECIES
292770 Rattus norvegicus
10653 Homo sapiens
20733 Mus musculus
Selected quality suppliers for anti-SPINT2 (SPINT2) Antibodies
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