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SPINT2 encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. Additionally we are shipping SPINT2 Antibodies (100) and SPINT2 Kits (8) and many more products for this protein.
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Our data indicate that hypoxic inhibition of JMJD3 activity reduces demethylation of H3K27me3, nucleosome removal, and hence induction of the STAT6 target gene CCL18, while induction of other STAT6-inducible genes such as SPINT2 remained unaffected by JMJD3.
Concomitant presence of TMPRSS13 (show TMPRSS13 Proteins) with HAI-2 mediates phosphorylation of residues in the intracellular domain of the protease, and it coincides with efficient transport of the protease to the cell surface and its subsequent shedding.
This study presented a molecular characterization of congenital tufting enteropathy Italian patients, and identified one mutation in the SPINT2 gene
study the methylation status of the promoter region of Serine peptidase inhibitor/hepatocyte growth factor activator inhibitor type 2 (SPINT2/HAI-2)
It suggests an involvement of SPINT2 in PCa (show FLVCR1 Proteins) tumorigenesis, probably in association with a post-translational regulation of SPINT2.
N-glycan branching regulates HAI-2 through different subcellular distribution and subsequently access to different target proteases
Matriptase (show ST14 Proteins) inhibition by HAI-2 requires the translocation of HAI-2 to the cell surface, a process which is observed in some breast cancer cells but not in mammary epithelial cells.
Epigenetic silencing of SPINT2 promotes cancer cell motility in malignant melanoma.
a missense mutation in the serine protease inhibitor SPINT2 may have a role in congenital sodium diarrhea
results suggest that the SPINT2 underexpression in the MSC (show MSC Proteins) from MDS (show PAFAH1B1 Proteins) patients is probably involved in the adhesion of progenitors to the bone marrow niche, through an increased HGF (show HGF Proteins) and SDF-1 (show CXCL12 Proteins) signaling pathway.
HAI-1 (show SPINT1 Proteins) regulates the activity of activated matriptase (show ST14 Proteins), whereas HAI-2 has an essential role in regulating prostasin (show PRSS8 Proteins)-dependent matriptase (show ST14 Proteins) zymogen activation.
mutations in Prss8 (show PRSS8 Proteins) restored placentation and normal development of HAI-1 (show SPINT1 Proteins)-deficient embryos and prevented early embryonic lethality, mid-gestation lethality due to placental labyrinth failure, and neural tube defects in HAI-2-deficient embryos.
HAI-1 (show SPINT1 Proteins) and -2 are overexpressed in the liver in cholangiopathies with ductular reactions and are possibly involved in liver fibrosis and hepatic differentiation.
Unlike HAI-1 (show SPINT1 Proteins) and matriptase (show ST14 Proteins), HAI-2 expression is detected in non-epithelial cells of brain and lymph nodes, suggesting that HAI-2 may also be involved in inhibition of serine proteases other than matriptase (show ST14 Proteins)
Inhibition of the transmembrane serine protease (show F2 Proteins) matriptase (show ST14 Proteins) (encoded by St14 (show ST14 Proteins)) is an essential function of HAI2 during tissue morphogenesis.
This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene.
hepatocyte growth factor activator inhibitor type 2
, placental bikunin
, serine protease inhibitor, Kunitz type 2
, kunitz-type protease inhibitor 2
, serine protease inhibitor, Kunitz type, 2