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anti-serine Peptidase Inhibitor, Kunitz Type 1 (SPINT1) Antibodies

The protein encoded by SPINT1 is a member of the Kunitz family of serine protease inhibitors. Additionally we are shipping serine Peptidase Inhibitor, Kunitz Type 1 Proteins (8) and serine Peptidase Inhibitor, Kunitz Type 1 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SPINT1 6692 O43278
SPINT1 311331  
SPINT1 20732 Q9R097
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Top anti-serine Peptidase Inhibitor, Kunitz Type 1 Antibodies at antibodies-online.com

Showing 10 out of 78 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB SPINT1 Antibody (Center) western blot analysis in human placenta tissue lysates (35µg/lane).This demonstrates the SPINT1 antibody detected the SPINT1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-SPINT1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human Muscle WB Suggested Anti-SPINT1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: Human Muscle 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-SPINT1 Antibody Titration: 0.2-1 ug/mlPositive Control: PANC1 cell lysate WB Suggested Anti-SPINT1  Antibody Titration: 0.2-1 µg/mL  Positive Control: PANC1 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated FACS, WB 100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB SPINT1 Antibody (Center)  western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the SPINT1 antibody detected the SPINT1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated FACS, IF, WB 100 μL Log in to see 8 to 10 Days
$529.83
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 16 Days
$163.90
Details

SPINT1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-serine Peptidase Inhibitor, Kunitz Type 1 Antibodies

  1. Human Polyclonal SPINT1 Primary Antibody for EIA, WB - ABIN954931 : Chen, Wang, Chou, Chen, Rorke, Chen, Chai, Eckert, Johnson, Lin: Regulation of the matriptase-prostasin cell surface proteolytic cascade by hepatocyte growth factor activator inhibitor-1 during epidermal differentiation. in The Journal of biological chemistry 2010 (PubMed)
    Show all 3 references for ABIN954931

More Antibodies against serine Peptidase Inhibitor, Kunitz Type 1 Interaction Partners

Human serine Peptidase Inhibitor, Kunitz Type 1 (SPINT1) interaction partners

  1. The findings suggest that the oncogenic activity of hepsin (show HPN Antibodies) arises not only from elevated expression level but also from depletion of HAI-1, events which together trigger gain-of-function activity impacting HGF (show HGF Antibodies)/MET signalling and epithelial cohesion

  2. HAI-1 may have a critical role in maintaining normal keratinocyte morphology through regulation of PAR-2 (show F2RL1 Antibodies)-dependent p38 mitogen-activated protein kinase (show MAPK14 Antibodies) signaling.

  3. the anti-migratory effects seen via gamma-catenin were driven by the expression of hepatocyte growth factor activator inhibitor Type I (HAI-1 or SPINT-1), an upstream inhibitor of the c-MET signaling pathway.

  4. Data suggest HAI1 exhibits structural features consistent with classification in MANEC subclass of PAN (show SUPT6H Antibodies)/apple domain family with unifying features such as two additional disulfide bonds, two extended loop regions, and additional alpha-helical elements.

  5. Matriptase (show ST14 Antibodies) activity was suppressed by the expression of HAI-1.

  6. The results of the present study identified HAI-1 as a favorable prognostic marker for prostate cancer and may indicate that HAI-1 could be a therapeutic target for the treatment of this malignancy.

  7. HAI-1 expression correlates with the differentiation status of colorectal epithelia and could serve as a differentiation marker.

  8. HAI-1 and HAI-2 influence proliferation and cell fate of NPCs and their expression levels are linked to BMP sign

  9. Crystal structures of matriptase (show ST14 Antibodies) in complex with its inhibitor hepatocyte growth factor activator inhibitor-1

  10. It is suggested that HAI-1 may play an important role in the pathogenesis of castration-resistant prostate cancer

Mouse (Murine) serine Peptidase Inhibitor, Kunitz Type 1 (SPINT1) interaction partners

  1. HAI-1 may have a critical role in maintaining normal keratinocyte morphology through regulation of PAR-2 (show F2RL1 Antibodies)-dependent p38 mitogen-activated protein kinase (show MAPK14 Antibodies) signaling.

  2. HAI-1 regulates the activity of activated matriptase (show ST14 Antibodies), whereas HAI-2 (show SPINT2 Antibodies) has an essential role in regulating prostasin (show PRSS8 Antibodies)-dependent matriptase (show ST14 Antibodies) zymogen activation.

  3. HAI-1 and HAI-2 influence proliferation and cell fate of NPCs and their expression levels are linked to BMP sign

  4. HAI-1/SPINT1 has a crucial role in suppressing intestinal tumorigenesis, which implies a novel link between epithelial cell surface (show EPCAM Antibodies) serine protease (show F2 Antibodies) inhibitors and protection from carcinogenic stimuli.

  5. mutations in Prss8 (show PRSS8 Antibodies) restored placentation and normal development of HAI-1-deficient embryos and prevented early embryonic lethality, mid-gestation lethality due to placental labyrinth failure, and neural tube defects in HAI-2 (show SPINT2 Antibodies)-deficient embryos.

  6. HAI-1 has a crucial suppressive role in oral squamous cell carcinoma cells' invasiveness.

  7. HAI-1 and -2 are overexpressed in the liver in cholangiopathies with ductular reactions and are possibly involved in liver fibrosis and hepatic differentiation.

  8. HAI-1/SPINT1 plays an important role in maintaining colonic epithelium integrity.

  9. HAI-1 is required for branching morphogenesis in the chorioallantoic placenta.

  10. Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth.

serine Peptidase Inhibitor, Kunitz Type 1 (SPINT1) Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms.

Gene names and symbols associated with SPINT1

  • serine peptidase inhibitor, Kunitz type 1 (SPINT1) antibody
  • serine peptidase inhibitor, Kunitz type 1 (Spint1) antibody
  • serine protease inhibitor, Kunitz type 1 (Spint1) antibody
  • HAI antibody
  • HAI-1 antibody
  • HAI1 antibody
  • MANSC2 antibody

Protein level used designations for SPINT1

serine peptidase inhibitor, Kunitz type 1 , kunitz-type protease inhibitor 1 , kunitz-type protease inhibitor 1-like , HAI-1 , hepatocyte growth factor activator inhibitor type 1 , serine protease inhibitor, Kunitz type 1 , hepatocyte growth factor activator inhibitor 1 , hepatocyte growth factor activator inhibitor-1

GENE ID SPECIES
423206 Gallus gallus
487501 Canis lupus familiaris
534040 Bos taurus
704578 Macaca mulatta
100157387 Sus scrofa
100345098 Oryctolagus cuniculus
100473505 Ailuropoda melanoleuca
100585940 Nomascus leucogenys
6692 Homo sapiens
311331 Rattus norvegicus
20732 Mus musculus
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