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serine Peptidase Inhibitor, Kunitz Type 1 Proteins (SPINT1)

The protein encoded by SPINT1 is a member of the Kunitz family of serine protease inhibitors. Additionally we are shipping serine Peptidase Inhibitor, Kunitz Type 1 Antibodies (78) and serine Peptidase Inhibitor, Kunitz Type 1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SPINT1 6692 O43278
Rat SPINT1 SPINT1 311331  
SPINT1 20732 Q9R097
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Top serine Peptidase Inhibitor, Kunitz Type 1 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Mouse Fc Tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Human His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SPINT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine) ,
,

Top referenced serine Peptidase Inhibitor, Kunitz Type 1 Proteins

  1. Mouse (Murine) SPINT1 Protein expressed in Human Cells - ABIN2007755 : Mathias, Dodd, Walters, Rhodes, Kanki, Look, Huttenlocher: Live imaging of chronic inflammation caused by mutation of zebrafish Hai1. in Journal of cell science 2007 (PubMed)

More Proteins for serine Peptidase Inhibitor, Kunitz Type 1 (SPINT1) Interaction Partners

Human serine Peptidase Inhibitor, Kunitz Type 1 (SPINT1) interaction partners

  1. The findings suggest that the oncogenic activity of hepsin (show HPN Proteins) arises not only from elevated expression level but also from depletion of HAI-1, events which together trigger gain-of-function activity impacting HGF (show HGF Proteins)/MET signalling and epithelial cohesion

  2. HAI-1 may have a critical role in maintaining normal keratinocyte morphology through regulation of PAR-2 (show F2RL1 Proteins)-dependent p38 mitogen-activated protein kinase (show MAPK14 Proteins) signaling.

  3. the anti-migratory effects seen via gamma-catenin were driven by the expression of hepatocyte growth factor activator inhibitor Type I (HAI-1 or SPINT-1), an upstream inhibitor of the c-MET signaling pathway.

  4. Data suggest HAI1 exhibits structural features consistent with classification in MANEC subclass of PAN/apple domain family with unifying features such as two additional disulfide bonds, two extended loop regions, and additional alpha-helical elements.

  5. Matriptase (show ST14 Proteins) activity was suppressed by the expression of HAI-1.

  6. The results of the present study identified HAI-1 as a favorable prognostic marker for prostate cancer and may indicate that HAI-1 could be a therapeutic target for the treatment of this malignancy.

  7. HAI-1 expression correlates with the differentiation status of colorectal epithelia and could serve as a differentiation marker.

  8. HAI-1 and HAI-2 influence proliferation and cell fate of NPCs and their expression levels are linked to BMP sign

  9. Crystal structures of matriptase (show ST14 Proteins) in complex with its inhibitor hepatocyte growth factor activator inhibitor-1

  10. It is suggested that HAI-1 may play an important role in the pathogenesis of castration-resistant prostate cancer

Mouse (Murine) serine Peptidase Inhibitor, Kunitz Type 1 (SPINT1) interaction partners

  1. HAI-1 may have a critical role in maintaining normal keratinocyte morphology through regulation of PAR-2 (show F2RL1 Proteins)-dependent p38 mitogen-activated protein kinase (show MAPK14 Proteins) signaling.

  2. HAI-1 regulates the activity of activated matriptase (show ST14 Proteins), whereas HAI-2 (show SPINT2 Proteins) has an essential role in regulating prostasin (show PRSS8 Proteins)-dependent matriptase (show ST14 Proteins) zymogen activation.

  3. HAI-1 and HAI-2 influence proliferation and cell fate of NPCs and their expression levels are linked to BMP sign

  4. HAI-1/SPINT1 has a crucial role in suppressing intestinal tumorigenesis, which implies a novel link between epithelial cell surface (show EPCAM Proteins) serine protease (show F2 Proteins) inhibitors and protection from carcinogenic stimuli.

  5. mutations in Prss8 (show PRSS8 Proteins) restored placentation and normal development of HAI-1-deficient embryos and prevented early embryonic lethality, mid-gestation lethality due to placental labyrinth failure, and neural tube defects in HAI-2 (show SPINT2 Proteins)-deficient embryos.

  6. HAI-1 has a crucial suppressive role in oral squamous cell carcinoma cells' invasiveness.

  7. HAI-1 and -2 are overexpressed in the liver in cholangiopathies with ductular reactions and are possibly involved in liver fibrosis and hepatic differentiation.

  8. HAI-1/SPINT1 plays an important role in maintaining colonic epithelium integrity.

  9. HAI-1 is required for branching morphogenesis in the chorioallantoic placenta.

  10. Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth.

serine Peptidase Inhibitor, Kunitz Type 1 (SPINT1) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms.

Gene names and symbols associated with SPINT1

  • serine peptidase inhibitor, Kunitz type 1 (SPINT1)
  • serine peptidase inhibitor, Kunitz type 1 (Spint1)
  • serine protease inhibitor, Kunitz type 1 (Spint1)
  • HAI protein
  • HAI-1 protein
  • HAI1 protein
  • MANSC2 protein

Protein level used designations for SPINT1

serine peptidase inhibitor, Kunitz type 1 , kunitz-type protease inhibitor 1 , kunitz-type protease inhibitor 1-like , HAI-1 , hepatocyte growth factor activator inhibitor type 1 , serine protease inhibitor, Kunitz type 1 , hepatocyte growth factor activator inhibitor 1 , hepatocyte growth factor activator inhibitor-1

GENE ID SPECIES
423206 Gallus gallus
487501 Canis lupus familiaris
534040 Bos taurus
704578 Macaca mulatta
100157387 Sus scrofa
100345098 Oryctolagus cuniculus
100473505 Ailuropoda melanoleuca
100585940 Nomascus leucogenys
6692 Homo sapiens
311331 Rattus norvegicus
20732 Mus musculus
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