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serine/arginine-Rich Splicing Factor 1 Proteins (SRSF1)

SRSF1 encodes a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. Additionally we are shipping SRSF1 Antibodies (61) and SRSF1 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SRSF1 6426 Q07955
SRSF1 110809 Q6PDM2
Rat SRSF1 SRSF1 689890  
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Top SRSF1 Proteins at antibodies-online.com

Showing 9 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,632.67
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,632.67
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$2,632.67
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SRSF1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Top referenced SRSF1 Proteins

  1. Human SRSF1 Protein expressed in Escherichia coli (E. coli) - ABIN1098765 : Kohtz, Jamison, Will, Zuo, Lührmann, Garcia-Blanco, Manley: Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors. in Nature 1994 (PubMed)
    Show all 2 references for ABIN1098765

  2. Human SRSF1 Protein expressed in Wheat germ - ABIN1319738 : Aissat, de Becdelièvre, Golmard, Vasseur, Costa, Chaoui, Martin, Costes, Goossens, Girodon, Fanen, Hinzpeter: Combined computational-experimental analyses of CFTR exon strength uncover predictability of exon-skipping level. in Human mutation 2013 (PubMed)

More Proteins for serine/arginine-Rich Splicing Factor 1 (SRSF1) Interaction Partners

Fruit Fly (Drosophila melanogaster) serine/arginine-Rich Splicing Factor 1 (SRSF1) interaction partners

  1. ASF1 cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 and hASF1a (show ASF1A Proteins) by TLK (show TLK2 Proteins) kinases.

  2. dASF1 has a direct role in modifying chromatin structure during DNA replication and this function of dASF1 is important for the processivity of the replication machinery.

  3. Asf1 is directed via interactions with sequence-specific complexes to mediate silencing of specific target genes.

  4. Histone chaperones ASF1 and NAP1 (show NAP1L1 Proteins) differentially modulate removal of active histone marks by LID-RPD3 (show HDAC1 Proteins) complexes during NOTCH (show NOTCH1 Proteins) silencing.

Human serine/arginine-Rich Splicing Factor 1 (SRSF1) interaction partners

  1. results strongly support SRSF1 as a prognostic biomarker in SCLC and provide a rationale for personalized therapy in SCLC

  2. NSrp70 (show NSRP1 Proteins) acts as a new molecular counterpart for alternative splicing of target RNA, counteracting SRSF1 and SRSF2 (show SRSF2 Proteins) splicing activity.

  3. we have identified for the first time a potential mechanism that involves the essential splicing factor (show SLU7 Proteins) ASF/SF2 through which morphine regulates splicing specificity of the MOR (show OPRM1 Proteins) encoding gene, OPRM1 (show OPRM1 Proteins).

  4. Global splicing analysis with RNA-seq revealed that exons carrying the hnRNP H (show HNRNPH1 Proteins)-binding GGGGG motif are predisposed to be skipped compared to those carrying the SRSF1-binding GGAGG motif in both human and mouse brains.

  5. We present experimental evidence that splicing factor (show SLU7 Proteins) SRSF1, SRSF2 (show SRSF2 Proteins), U2AF35 (show U2AF1 Proteins), U2AF65 (show U2AF59 Proteins) and KHSRP (show KHSRP Proteins) expression levels in gastrointestinal tract (colon, gastric and pancreatic) tumors differ compare to healthy tissues and in cell lines

  6. These findings have revealed a molecular interplay between cellular SRSF1 and viral T-antigen in controlling JC virus gene expression.

  7. These include alternative splicing of SRSF1 itself.

  8. SF2 contributes to the elevated levels of ERK (show EPHB2 Proteins) activation in hepatocellular carcinoma cells through modulating key component(s) downstream of growth factor receptors and upstream of ERK (show EPHB2 Proteins).

  9. These results suggest that MALAT1 may function as a promoter of gastric cancer cell proliferation partly by regulating SF2/ASF.

  10. SRSF1 regulates CD3zeta (show CD247 Proteins) expression in human T cells and may contribute to the T cell defect in systemic lupus erythematosus.

Mouse (Murine) serine/arginine-Rich Splicing Factor 1 (SRSF1) interaction partners

  1. The expression levels of three splicing factors, ESRP1 (show ESRP1 Proteins), PTB (show PTBP1 Proteins) and SF2/ASF, are significantly altered during cardiac hypertrophy in mice.

  2. RRP1B suppresses metastatic progression by altering the transcriptome through its interaction with splicing regulators such as SRSF1

  3. Deletion of RRM1 (show RRM1 Proteins) eliminated the splicing activity of SRSF1 and thus cellular transformation.

  4. Specific effects on regulated splicing by SR proteins SRSF1 and SRSF2 (show SRSF2 Proteins) depends on a complex set of relationships with multiple other SR proteins in mammalian genomes.

  5. Treatment with IL-17 (show IL17A Proteins) prolongs the half-life of chemokine (show CCL1 Proteins) CXCL1 mRNA via the adaptor TRAF5 (show TRAF5 Proteins) and the splicing-regulatory factor SF2 (ASF).

  6. analysis of the miRNA-mediated interaction between leukemia/lymphoma-related factor (LRF (show ZBTB7A Proteins)) and alternative splicing factor/splicing factor (show SLU7 Proteins) 2 (ASF/SF2) affects cell senescence and apoptosis

  7. Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 (show SMN1 Proteins) causes spinal muscular atrophy in the absence of SMN1 (show SMN1 Proteins)

  8. Both hnRNP A1 (show HNRNPA1 Proteins) and alternative splicing factor/splicing factor (show SLU7 Proteins) 2 contents rose in adenomas and during injury-induced hyperplasia compared to control lungs

  9. These results highlight the requirement of Sfrs1-mediated alternative splicing for the survival of retinal neurons, with sensitivity defined by the window of time in which the neuron was generated.

SRSF1 Protein Profile

Protein Summary

This gene encodes a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 13.

Gene names and symbols associated with SRSF1

  • anti-silencing factor 1 (asf1)
  • serine/arginine-rich splicing factor 1 (srsf1)
  • serine/arginine-rich splicing factor 1 (SRSF1)
  • serine/arginine-rich splicing factor 1 (Srsf1)
  • serine/arginine-rich splicing factor 1b (srsf1b)
  • 1110054N12Rik protein
  • 5730507C05Rik protein
  • 6330415C05Rik protein
  • AI482334 protein
  • Asf protein
  • Asf1 protein
  • AW491331 protein
  • CG9383 protein
  • dASF/SF2 protein
  • dAsf1 protein
  • DKFZp469K2419 protein
  • Dmel\\CG9383 protein
  • l(3)76BDq protein
  • Sf2 protein
  • SF2p33 protein
  • Sfrs1 protein
  • sfrs1b protein
  • SRp30a protein
  • wu:fb80g05 protein
  • zgc:65898 protein
  • zgc:76897 protein
  • zgc:111894 protein

Protein level used designations for SRSF1

CG9383-PA , CG9383-PB , anti- silencing function 1 , anti-silencing factor , asf1-PA , asf1-PB , splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor) , ASF-1 , SR splicing factor 1 , alternative-splicing factor 1 , pre-mRNA-splicing factor SF2, P33 subunit , splicing factor 2 , splicing factor, arginine/serine-rich 1 , splicing factor arginine/serine-rich 1 , splicing factor, arginine/serine-rich 1B , ASF/SF2 , pre-mRNA-splicing factor SRp30a , splicing factor, arginine/serine-rich 1 (ASF/SF2) , serine/arginine-rich splicing factor 1B , splicing factor, arginine/serine-rich 1b

GENE ID SPECIES
40141 Drosophila melanogaster
399226 Xenopus laevis
772264 Gallus gallus
6426 Homo sapiens
609693 Canis lupus familiaris
654327 Sus scrofa
615796 Bos taurus
110809 Mus musculus
689890 Rattus norvegicus
100173318 Pongo abelii
393565 Danio rerio
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