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serine/arginine-Rich Splicing Factor 2 Proteins (SRSF2)

The protein encoded by SRSF2 is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Additionally we are shipping SRSF2 Antibodies (30) and SRSF2 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SRSF2 6427 Q01130
SRSF2 20382 Q62093
SRSF2 494445 Q6PDU1
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Top SRSF2 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,548.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,548.33
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,552.00
Details

SRSF2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for serine/arginine-Rich Splicing Factor 2 (SRSF2) Interaction Partners

Human serine/arginine-Rich Splicing Factor 2 (SRSF2) interaction partners

  1. NSrp70 (show NSRP1 Proteins) acts as a new molecular counterpart for alternative splicing of target RNA, counteracting SRSF1 (show SRSF1 Proteins) and SRSF2 splicing activity.

  2. We present experimental evidence that splicing factor (show SLU7 Proteins) SRSF1 (show SRSF1 Proteins), SRSF2, U2AF35 (show U2AF1 Proteins), U2AF65 (show U2AF59 Proteins) and KHSRP (show KHSRP Proteins) expression levels in gastrointestinal tract (colon, gastric and pancreatic) tumors differ compare to healthy tissues and in cell lines.

  3. Data show that tet methylcytosine dioxygenase 2 TET2, isocitrate dehydrogenases 1/2 IDH1 (show IDH1 Proteins)/IDH2 (show IDH2 Proteins), serine/arginine-rich splicing factor 2 SRSF2, splicing factor 3b subunit 1 SF3B1 (show SF3B1 Proteins), and ras proteins (KRAS/NRAS) are not conserved in dog mast Cell tumors.

  4. Depletion of two of the most potent inhibitors of SMP2 (show LPIN3 Proteins) exon 7 inclusion, SRSF2 or SRSF3 (show SRSF3 Proteins), in cell lines derived from SMA (show SMN1 Proteins) patients, increased SMN2 (show SMN1 Proteins) exon 7 inclusion and SMN (show STMN1 Proteins) protein level.

  5. HIV-1-Tat (show TAT Proteins) Protein Inhibits SC35-mediated Tau Exon 10 Inclusion through Up-regulation of DYRK1A (show DYRK1A Proteins) Kinase.

  6. Our results show that diverse microenvironment cues affect different attributes of the SC-35 organizational metrics and lead to distinct emergent organizational patterns.

  7. findings shed light on the mechanism of the disease-associated SRSF2 mutation in splicing regulation and also reveal a group of misspliced mRNA isoforms for potential therapeutic targeting

  8. The authors propose that splicing at 3'ss A3 is dependent on binding of the enhancing SR proteins SRSF2 and SRSF6 to the HIV-1 tat ESE and ESE2 sequence.

  9. clinical relevance of SRSF2 mutations in Chinese myelodysplastic syndrome

  10. SRSF2 mutations are frequent in chronic myelomonocytic leukemia patients, but show a relatively lower incidence in Chinese patients.

Mouse (Murine) serine/arginine-Rich Splicing Factor 2 (SRSF2) interaction partners

  1. HIV-1-Tat (show TAT Proteins) Protein Inhibits SC35-mediated Tau Exon 10 Inclusion through Up-regulation of DYRK1A (show DYRK1A Proteins) Kinase.

  2. The findings suggest that intact SRSF2 is essential for the functional integrity of the hematopoietic system and that its mutations likely contribute to development of myelodysplastic syndromes.

  3. SRSF2 mutations alter SRSF2's normal sequence-specific RNA binding activity, thereby altering the recognition of specific exonic splicing enhancer motifs to drive recurrent mis (show AMH Proteins)-splicing of key hematopoietic regulators

  4. Study reports that SRSF2 (also known as SC35, an SR-splicing factor (show SLU7 Proteins)) is part of the 7SK complex assembled at gene promoters and plays a direct role in transcription pause release.

  5. Specific effects on regulated splicing by SR proteins SRSF1 (show SRSF1 Proteins) and SRSF2 depends on a complex set of relationships with multiple other SR proteins in mammalian genomes.

  6. Deficiency of the splicing factor (show SLU7 Proteins) Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn (show STMN1 Proteins) splicing.

  7. Oct-4 distribution was examined relative to that of the unphosphorylated form of RNA polymerase II (Pol II) and splicing factor (SC 35) in the intranuclear entities such as perichromatin fibrils.

  8. intranuclear distribution of SC35 is dependent on GSK-3

  9. These findings reveal the involvement of SC35 in specific pathways in regulating cell proliferation and genomic stability during mammalian organogenesis and suggest its potential function in tumorigenesis.

  10. splicing factor SC35 has an active role in transcriptional elongation

SRSF2 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11.

Gene names and symbols associated with SRSF2

  • serine/arginine-rich splicing factor 2 (SRSF2)
  • serine/arginine-rich splicing factor 2 (Srsf2)
  • serine/arginine-rich splicing factor 2 (srsf2)
  • D11Wsu175e protein
  • MRF-1 protein
  • pr264 protein
  • sc-35 protein
  • sc35 protein
  • sfrs2 protein
  • sfrs2a protein
  • Sfrs10 protein
  • srp30b protein

Protein level used designations for SRSF2

SR splicing factor 2 , splicing component, 35 kDa , splicing factor SC35 , splicing factor, arginine/serine-rich 2 , myelin regulatory factor 1 , putative myelin regulatory factor 1 , splicing factor Sc35 , splicing factor, arginine/serine-rich 2 (SC-35) , SC-35 , PR 264 protein , arginine/serine-rich2 splicing factor

GENE ID SPECIES
6427 Homo sapiens
20382 Mus musculus
494445 Rattus norvegicus
508312 Bos taurus
396195 Gallus gallus
768117 Sus scrofa
380435 Xenopus laevis
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