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The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. Additionally we are shipping serine/threonine Kinase 24 Proteins (11) and serine/threonine Kinase 24 Kits (2) and many more products for this protein.
Showing 10 out of 85 products:
Human Polyclonal STK24 Primary Antibody for EIA, IHC (p) - ABIN360314
Huang, Wu, Hsu, Lee, Lai, Lu, Huang, Leu, Shih, Fang, Robinson, Kung, Yuan: Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis. in The Journal of biological chemistry 2002
Show all 4 references for ABIN360314
Human Monoclonal STK24 Primary Antibody for IF, WB - ABIN968346
Lian, Toker, Badwey: Phosphorylation of the activation loop of gamma p21-activated kinase (gamma-Pak) and related kinases (MSTs) in normal and stressed neutrophils. in Journal of immunology (Baltimore, Md. : 1950) 2001
Show all 2 references for ABIN968346
Human Monoclonal STK24 Primary Antibody for IF, WB - ABIN968347
Schinkmann, Blenis: Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements. in The Journal of biological chemistry 1997
Show all 2 references for ABIN968347
Human Polyclonal STK24 Primary Antibody for IHC, ELISA - ABIN1535332
Dunham, Matthews, Burton, Ashurst, Howe, Ashcroft, Beare, Burford, Hunt, Griffiths-Jones, Jones, Keenan, Oliver, Scott, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey et al.: The DNA sequence and analysis of human chromosome 13. ... in Nature 2004
CCM3 (show PDCD10 Antibodies) signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations.
Mst3b, a neuron-specific homolog of the yeast kinase Ste20, is critical for axon outgrowth. Mst3b is activated in response to trophic factors, and suppressing its expression
This study demonistrated that MST3 kinase phosphorylates TAO1 (show TAOK2 Antibodies)/2 to enable Myosin Va (show MYO5A Antibodies) function in promoting spine synapse development.
This review notes that in the SOK1 (show STK25 Antibodies) and MST4 (show MST4 Antibodies) germinal center kinase (show MAP4K2 Antibodies) III family of proteins, exon 1 encodes a 5' untranslated region, but this is not the case for MST3.
These data provide molecular understanding of the mechanism by which MO25 (show CAB39 Antibodies) isoforms regulates the activity of STE20 family protein kinases.
results show that a STRADalpha-rac1-PAK1 (show PAK1 Antibodies) pathway regulates cell polarity and invasion in LKB1 (show STK11 Antibodies)-null cells. It also suggests that while the function of LKB1 (show STK11 Antibodies) and STRADalpha undoubtedly overlap, they may also have mutually exclusive roles
mechanism of regulation of MST3
Striatin (show STRN Antibodies) orchestrates the regulation of Mst3 by PP2A (show PPP2R4 Antibodies).
Mst3 is up-regulated and plays an important role in hypoxia-induced apoptosis of human trophoblasts.
five crystal structures of the catalytic domain of MST3 are presented, including a complex with ADP and manganese, a unique cofactor preferred by the enzyme, and a complex with adenine.
Proteolytic activation of Mst3 by caspases.
Mst3 contains signals which may cooperate to control the subcellular distribution of Mst3.
Mst3 phosphorylates RhoA (show RHOA Antibodies) at Ser26, thereby negatively regulating the activity of RhoA (show RHOA Antibodies) in neurons.
STK24 appears to suppress exocytosis by interacting and competing with UNC13D (show UNC13D Antibodies) C2B domain for lipid binding, whereas CCM3 (show PDCD10 Antibodies) has dual roles in exocytosis regulation.
The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation. Members of the PAK subfamily (see PAK3\; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2\; MIM 603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases (Zhou et al., 2000
serine/threonine kinase 24 (STE20 homolog, yeast)
, serine/threonine-protein kinase 24
, STE20-like kinase 3
, STE20-like kinase MST3
, mammalian STE20-like protein kinase 3
, sterile 20-like kinase 3
, mammalian sterile twenty 3 kinase