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serine/threonine Kinase 25 Proteins (STK25)

STK25 encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. Additionally we are shipping STK25 Antibodies (60) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
STK25 10494 O00506
Rat STK25 STK25 373542  
STK25 59041 Q9Z2W1
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Top STK25 Proteins at antibodies-online.com

Showing 9 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,188.17
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
$570.24
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

STK25 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

More Proteins for serine/threonine Kinase 25 (STK25) Interaction Partners

Human serine/threonine Kinase 25 (STK25) interaction partners

  1. STK25 regulates lipid partitioning in human liver cells by controlling TAG synthesis as well as lipolytic activity and thereby NEFA (show NUCB2 Proteins) release from lipid droplets for beta-oxidation and TAG secretion.

  2. Our results suggest that MST4 (show MST4 Proteins), STK25 and PDCD10 (show PDCD10 Proteins) are upregulated in prostate cancer and may play roles in prostate tumorigenesis.

  3. This review notes that all 3 human germinal center kinase (show MAP4K2 Proteins) III genes consist of 12 exons and are ubiquitously expressed. In SOK1 and MST4 (show MST4 Proteins), exon 1 encodes a 5' untranslated region, but this is not the case for MST3 (show STK24 Proteins).

  4. Down-modulation of STK25, but not STK24 (show STK24 Proteins), rescued medulloblastoma cells from NGF (show NGFB Proteins)-induced TrkA (show NTRK1 Proteins)-dependent cell death, suggesting that STK25 is part of the death-signaling pathway initiated by TrkA (show NTRK1 Proteins) and CCM2 (show CCM2 Proteins).

  5. PDCD10 (show PDCD10 Proteins) might be a regulatory adaptor required for STK25 functions, which differ distinctly depending on the redox status of the cells that may be potentially related to tumor progression.

  6. Significantly higher STK25 levels were observed in the skeletal muscle of type 2 diabetic patients, compared with individuals with normal glucose tolerance.

  7. The results of the study results indicate that attenuation of SOK1 enhanced cell migration and lead to changes in the expression of migration-associated proteins such as FAK (show PTK2 Proteins) and GM130 (show GOLGA2 Proteins).

  8. In cultured human endothelial cells, CCM3 (show PDCD10 Proteins) and STK25 regulated barrier function in a manner similar to CCM2 (show CCM2 Proteins), and STKs negatively regulated Rho by directly activating moesin (show MSN Proteins).

  9. 14-3-3zeta (show YWHAZ Proteins) is a specific substrate for YSK1 that localizes to the Golgi apparatus, and potentially links YSK1 signaling at the Golgi apparatus with protein transport.

  10. Ste20 (show STK24 Proteins) family member (MAP4K3 (show MAP4K3 Proteins)) that is required for maximal S6K (S6 kinase (show RPS6KB1 Proteins))/4E-BP1 (show EIF4EBP1 Proteins) [eIF4E (eukaryotic initiation factor 4E (show EIF4E Proteins)) that is required for maximal S6K (S6 kinase (show RPS6KB1 Proteins)).

Mouse (Murine) serine/threonine Kinase 25 (STK25) interaction partners

  1. we challenged Stk25 knockout and wild-type mice with a high-fat diet and showed that STK25 deficiency suppressed development of hyperglycemia and hyperinsulinemia, improved glucose tolerance, reduced liver gluconeogenesis and increased insulin (show INS Proteins) sensitivity

  2. Stk25 transgenic mice challenged with a high-fat diet displayed a dramatic increase in liver steatosis and hepatic insulin (show INS Proteins) resistance compared to wild-type siblings.

  3. Loss of Stk25 function early in development likely leads to functional compensation for its roles in neuronal development.

  4. Findings suggest that overexpression of STK25 in conditions of excess dietary fuels associates with a shift in the metabolic balance in peripheral tissues from lipid oxidation to storage, leading to a systemic insulin (show INS Proteins) resistance.

  5. Down-modulation of STK25, but not STK24 (show STK24 Proteins), rescued medulloblastoma cells from NGF (show NGFB Proteins)-induced TrkA (show NTRK1 Proteins)-dependent cell death, suggesting that STK25 is part of the death-signaling pathway initiated by TrkA (show NTRK1 Proteins) and CCM2 (show CCM2 Proteins).

  6. Stk25 is a genetic modifier of Tau phosphorylation in Dab1 (show DAB1 Proteins)-mutant mice.

  7. This demonstrates that the balance between Reelin (show RELN Proteins)-Dab1 (show DAB1 Proteins) signaling and LKB1 (show STK11 Proteins)-Stk25-GM130 (show GOLGA2 Proteins) regulates Golgi dispersion, axon specification, and dendrite growth and provides insights into the importance of the Golgi apparatus for cell polarization.

  8. Mst3b (show STK24 Proteins) regulates axon regeneration in both CNS and PNS neurons in Nervous System Diseases.

  9. Confirmed Hdlq14 as a separate independent quantitative trait locus for HDL (show HSD11B1 Proteins) and narrowed the region to 2 genes, Farp2 (show FARP2 Proteins) and Stk25, with considerable evidence for both.

STK25 Protein Profile

Protein Summary

This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene.

Gene names and symbols associated with STK25

  • serine/threonine kinase 25 (STK25)
  • serine/threonine kinase 25 (Stk25)
  • serine/threonine kinase 25 (yeast) (Stk25)
  • 1500019J11Rik protein
  • AU018434 protein
  • C86992 protein
  • SOK1 protein
  • Ste20-like protein
  • Ysk1 protein

Protein level used designations for STK25

Ste20, yeast homolog , serine/threonine-protein kinase 25 , ste20-like kinase , ste20/oxidant stress response kinase 1 , sterile 20/oxidant stress-response kinase 1 , serine/threonine kinase 25 (STE20 homolog, yeast) , SOK-1 , Ste20-like kinase , Yeast Sps1/Ste20-related kinase 1 , serine/threonine kinase 25 (Ste20, yeast homolog)

GENE ID SPECIES
10494 Homo sapiens
373542 Rattus norvegicus
373543 Bos taurus
59041 Mus musculus
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