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STK3 encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Additionally we are shipping STK3 Proteins (15) and many more products for this protein.
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Chicken Polyclonal STK3 Primary Antibody for WB - ABIN2783468
Seidel, Schagdarsurengin, Blümke, Würl, Pfeifer, Hauptmann, Taubert, Dammann: Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma. in Molecular carcinogenesis 2007
using an Mst2 mutation that disrupts homotypic dimerization, we showed that the monomeric Mst2-SARAH domain could form a stable complex of 1:1 stoichiometric ratio with WW45 (show SAV1 Antibodies) refolded under acidic pH.
The MST1/2-SAV1 complex, a core component of the Hippo pathway, promotes ciliogenesis.
These results suggest that AIF (show AIFM1 Antibodies) downregulation is a common event in kidney tumor development. AIF (show AIFM1 Antibodies) loss may lead to decreased STK3 activity, defective apoptosis and malignant transformation
Hippo and Yap (show YAP1 Antibodies) regulate cardiomyocyte death and regeneration.
results reveal a novel role of Mst2 in stress-dependent cardiac hypertrophy and remodeling in the adult mouse and likely human heart
Results indicate that changes in phosphorylation orchestrate interactions between kinases and phosphatases in Hippo (MST1 (show MST1 Antibodies)/2 protein kinases) signaling, providing a putative mechanism for pathway regulation.
RASSF5 (show RASSF5 Antibodies) can act as an inhibitor or a potential positive regulator of Mst2, depending on whether it binds to Mst2 before or after activation-loop phosphorylation.
results of the present study revealed that, in addition to the phosphorylated YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies), the Hippo pathway can suppress the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway directly through MST1 (show MST1 Antibodies)/2
The ability of K-Ras to activate MST2 and MST2-dependent apoptosis is determined by the differential activation kinetics of mutant K-Ras and wild type K-Ras.
The identification of the c-Abl (show ABL1 Antibodies) tyrosine kinase as a novel upstream activator of MST2 suggests that the conserved c-Abl (show ABL1 Antibodies)-MST (show MAP3K10 Antibodies) signaling cascade plays an important role in oxidative stress-induced (show SQSTM1 Antibodies) neuronal cell death.
Studies indicate that Hippo (Hpo (show GFER Antibodies); MST1 (show MST1 Antibodies)/2 in mammals) signaling pathway plays a central role in the cell fate-specification process.
Mst2 is involved in bone homeostasis, functioning as a reciprocal regulator of osteoclast and osteoblast differentiation through the NF-kappaB (show NFKB1 Antibodies) pathway
the TLR-Mst1 (show MST1 Antibodies)-Mst2-Rac (show AKT1 Antibodies) signaling axis is critical for effective phagosome-mitochondrion function and bactericidal activity
These data indicate that that inhibition of mammalian sterile 20-like kinase 1 (show STK4 Antibodies) rescued cardiac fibrosis and myocardial dysfunction in chronic beta1-adrenergic receptor stimulation-induced cardiomyopathy
Phosphorylation of LC3 (show MAP1LC3A Antibodies) by the STK3 (show PKN1 Antibodies) and STK4 is essential for autophagy.
These results identify MST2, not MST1 (show MST1 Antibodies), as a critical regulator of caspase (show CASP3 Antibodies)-mediated photoreceptor cell death in the detached retina and indicate its potential as a future neuroprotection target.
Mst1 (show MST1 Antibodies)/2 regulate placental development by control of trophoblast cell differentiation and labyrinthine vasculature at midgestation and Mst1 (show MST1 Antibodies)/2 control labyrinth morphogenesis in trophoblast- and fetal endothelial-dependent manners.
results showed that Mst1 (show MST1 Antibodies)/Mst2 are required for proper cardiac lineage cell development and teratoma (show DND1 Antibodies) formation.
these findings indicate that Mst1 (show MST1 Antibodies)/2 are important for controlling Treg development and preventing autoimmunity in mice, but also shed new light on our understanding of Mst1 (show MST1 Antibodies) deficiency-mediated human immunodeficiency syndrome.
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
, STE20-like kinase MST2
, mammalian STE20-like protein kinase 2
, serine/threonine kinase 3 (STE20 homolog, yeast)
, serine/threonine kinase 3 (Ste20, yeast homolog)
, serine/threonine-protein kinase 3
, serine/threonine-protein kinase Krs-1
, protein kinase homolog
, serine/threonine kinase 3 (STE20 homolog)