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STK3 encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Additionally we are shipping STK3 Antibodies (101) and many more products for this protein.
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Results show that STK3 is targeted by Casp6 (show CASP6 Proteins) and demonstrate that alterations in STK3 protein expression levels and post-translational modifications are detected in a cellular model of HD and caspase (show CASP3 Proteins)-mediated generation of STK3 fragments observed under conditions of stress in cells expressing mhtt.
using an Mst2 mutation that disrupts homotypic dimerization, we showed that the monomeric Mst2-SARAH domain could form a stable complex of 1:1 stoichiometric ratio with WW45 (show SAV1 Proteins) refolded under acidic pH.
The MST1/2-SAV1 complex, a core component of the Hippo pathway, promotes ciliogenesis.
These results suggest that AIF (show AIFM1 Proteins) downregulation is a common event in kidney tumor development. AIF (show AIFM1 Proteins) loss may lead to decreased STK3 activity, defective apoptosis and malignant transformation
Hippo and Yap (show YAP1 Proteins) regulate cardiomyocyte death and regeneration.
results reveal a novel role of Mst2 in stress-dependent cardiac hypertrophy and remodeling in the adult mouse and likely human heart
Results indicate that changes in phosphorylation orchestrate interactions between kinases and phosphatases in Hippo (MST1 (show MST1 Proteins)/2 protein kinases) signaling, providing a putative mechanism for pathway regulation.
RASSF5 (show RASSF5 Proteins) can act as an inhibitor or a potential positive regulator of Mst2, depending on whether it binds to Mst2 before or after activation-loop phosphorylation.
results of the present study revealed that, in addition to the phosphorylated YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins), the Hippo pathway can suppress the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway directly through MST1 (show MST1 Proteins)/2
The ability of K-Ras to activate MST2 and MST2-dependent apoptosis is determined by the differential activation kinetics of mutant K-Ras and wild type K-Ras.
Studies indicate that Hippo (Hpo (show GFER Proteins); MST1 (show MST1 Proteins)/2 in mammals) signaling pathway plays a central role in the cell fate-specification process.
Mst2 is involved in bone homeostasis, functioning as a reciprocal regulator of osteoclast and osteoblast differentiation through the NF-kappaB (show NFKB1 Proteins) pathway
the TLR-Mst1 (show MST1 Proteins)-Mst2-Rac (show AKT1 Proteins) signaling axis is critical for effective phagosome-mitochondrion function and bactericidal activity
These data indicate that that inhibition of mammalian sterile 20-like kinase 1 (show STK4 Proteins) rescued cardiac fibrosis and myocardial dysfunction in chronic beta1-adrenergic receptor stimulation-induced cardiomyopathy
Phosphorylation of LC3 (show MAP1LC3A Proteins) by the STK3 (show PKN1 Proteins) and STK4 is essential for autophagy.
These results identify MST2, not MST1 (show MST1 Proteins), as a critical regulator of caspase (show CASP3 Proteins)-mediated photoreceptor cell death in the detached retina and indicate its potential as a future neuroprotection target.
Mst1 (show MST1 Proteins)/2 regulate placental development by control of trophoblast cell differentiation and labyrinthine vasculature at midgestation and Mst1 (show MST1 Proteins)/2 control labyrinth morphogenesis in trophoblast- and fetal endothelial-dependent manners.
results showed that Mst1 (show MST1 Proteins)/Mst2 are required for proper cardiac lineage cell development and teratoma (show DND1 Proteins) formation.
these findings indicate that Mst1 (show MST1 Proteins)/2 are important for controlling Treg development and preventing autoimmunity in mice, but also shed new light on our understanding of Mst1 (show MST1 Proteins) deficiency-mediated human immunodeficiency syndrome.
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
, STE20-like kinase MST2
, mammalian STE20-like protein kinase 2
, serine/threonine kinase 3 (STE20 homolog, yeast)
, serine/threonine kinase 3 (Ste20, yeast homolog)
, serine/threonine-protein kinase 3
, serine/threonine-protein kinase Krs-1
, protein kinase homolog
, serine/threonine kinase 3 (STE20 homolog)