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The protein encoded by STK4 is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. Additionally we are shipping STK4 Antibodies (74) and STK4 Proteins (16) and many more products for this protein.
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Mouse (Murine) STK4 ELISA Kit for Sandwich ELISA - ABIN1889361
Han, Stuart, Degen: Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor. in Biochemistry 1991
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Data indicate that two siblings with a serine/threonine kinase 4 (STK4) mutation with features of autosomal recessive (AR) hyperimmunoglobulin E syndrome and autoimmune cytopenias.
STK4 was reduced in macrophages from human hepatoma patients and was inversely associated with the levels of IRAK1, IL-6, and phospho-p65 or phospho-STAT3. Serum STK4 levels were specifically decreased in HCC patients with high levels of IL-6.
The MST1/2-SAV1 complex, a core component of the Hippo pathway, promotes ciliogenesis.
the kinase Mst1 (show MST1 ELISA Kits) controls selective CCR7 (show CCR7 ELISA Kits)-dependent functions in human mature dendritic cells.
Genetic inactivation of STK4 restores YAP1 (show YAP1 ELISA Kits) levels, triggering cell death in hematologic malignancies.
Results indicate that changes in phosphorylation orchestrate interactions between kinases and phosphatases in Hippo (MST1 (show MST1 ELISA Kits)/2 protein kinases) signaling, providing a putative mechanism for pathway regulation.
Inhibition of Mst1 (show MST1 ELISA Kits) kinase activation in cardiomyocytes protects against cell hypoxia.
Under diabetogenic conditions, MST1 (show MST1 ELISA Kits) was strongly activated in beta cells, and induced apoptosis via BIM (show BCL2L11 ELISA Kits) upregulation, and impaired insulin (show INS ELISA Kits) secretion via phosphorylation of PDX1 (show PDX1 ELISA Kits).
PHLPP1 (show PHLPP1 ELISA Kits) is a binding protein for Mst1 (show MST1 ELISA Kits) and it modulates the Hippo pathway by dephosphorylating Mst1 (show MST1 ELISA Kits) at the inhibitory Thr (show TRH ELISA Kits)(387) of Mst1 (show MST1 ELISA Kits).
Results indicated that Mst1 (show MST1 ELISA Kits) might be a promising anticancer target.
mammalian sterile 20-like kinase 1 (Mst1) knockout abolished the protective effects of Luteolin administration in a mouse model of myocardial infarction.
Studies indicate that Hippo (Hpo (show GFER ELISA Kits); MST1 (show MST1 ELISA Kits)/2 in mammals) signaling pathway plays a central role in the cell fate-specification process.
Data (including data from studies in knockout/transgenic mice) suggest Mst1 (show MST1 ELISA Kits) has functional roles in cytotoxic T-lymphocytes and in inhibition of tumor progression/size of T-cell lymphoma; Mst1 (show MST1 ELISA Kits) may be involved in tumor immunity/immunologic surveillance.
the TLR-Mst1 (show MST1 ELISA Kits)-Mst2 (show STK3 ELISA Kits)-Rac (show AKT1 ELISA Kits) signaling axis is critical for effective phagosome-mitochondrion function and bactericidal activity
Macrophage-specific Stk4 deletion resulted in chronic inflammation, liver fibrosis, and hepatomas in mice exposed to liver insult.
STK4 is a novel candidate biomarker for early stage pancreatic cancer.
Phosphorylation of LC3 (show MAP1LC3A ELISA Kits) by the STK3 (show PKN1 ELISA Kits) and STK4 is essential for autophagy.
These results identify MST2 (show STK3 ELISA Kits), not MST1 (show MST1 ELISA Kits), as a critical regulator of caspase (show CASP3 ELISA Kits)-mediated photoreceptor cell death in the detached retina and indicate its potential as a future neuroprotection target.
Mst1 (show MST1 ELISA Kits)/2 regulate placental development by control of trophoblast cell differentiation and labyrinthine vasculature at midgestation and Mst1 (show MST1 ELISA Kits)/2 control labyrinth morphogenesis in trophoblast- and fetal endothelial-dependent manners.
Mst1 (show MST1 ELISA Kits) is required for Treg cells to mediate contact-dependent suppressor functions.
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.
, STE20-like kinase MST1
, dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2))
, kinase responsive to stress 2
, mammalian STE20-like protein kinase 1
, mammalian sterile 20-like 1
, serine/threonine-protein kinase 4
, serine/threonine-protein kinase Krs-2
, Yeast Sps1/Ste20-related kinase 3
, sterile 20-like kinase 1